#NEXUS [MacClade 4.08 registered to Masaki Ishikawa, ERATO Hasebe Project] BEGIN DATA; DIMENSIONS NTAX=94 NCHAR=1168; FORMAT DATATYPE=PROTEIN SYMBOLS = " 1 2 3 4" MISSING=? GAP=- ; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] 'gi|15219522|ref|NP 177510.1| CDKD1;1; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k' M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPKKVADRYLKREVLGQGTYGVVF--------KATD-TKNGETVAIKKI-----R----LGKE-------KEGVNVTALREIKLLKEL-K---------HPHIIELI-DAFP--HK-EN-LHIVFEFM-ETDLEAVIRDRNLY--LSPGDVKSYLQMILKGLEYCHGKWVLHRDMKPNNLLIGPN-GQLKLADFGLARIFGSPG------RKFTHQVFARWYRAPELLFGAKQYDGAVDVWAAGCIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPK-ADQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMICLPDYVE--YQFVPAPS------LRSL-LPTVSEDALDLLSKMF---------------TYDPK----------------SRISIQQALKHRYFTSAP-------------------SPTDPLKLPRPVS-KQDAKSSDSKL-----EAIKVLSPAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFRRVMPDR-GKSGNGFKDQSVDVMRQASH---------DGQAPMSLD-FTILAERPPNRPTITSADRSHLKRK------LDLEFL------- [398] 'gi|15220917|ref|NP 173244.1| CDKD1;3; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQPKKVADRYLKQEVLGQGTYGVVF--------KATD-TKTEQTVAIKKI-----R----LGKQ-------REGVNITALREIKMLKEL-K---------HPHIILLI-DAFP--HK-EN-LHLVFEFM-ETDLEAVIRDSNIF--LSPADIKSYLLMTFKGLAYCHDKWVLHRDMKPNNLLIGVD-GQLKLADFGLARIFGSPN------RKFTHQVFARWYRAPELLFGAKQYGAAVDVWAVACIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPK-ADQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTKLPDYVE--YQFVPAPS------LRSL-FPAVSDDALDLLSKMF---------------TYDPK----------------ARISIKQALEHRYFTSAP-------------------APTDPAKLPKPVP-KQDGKSSYGKH-----EAITVQSPPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLRRVMPER-GR---------VDSLKSHVD--------KDQQAPMSLD-FTILAERPPNRPTITSADRSHLKRK------LDLEFQ------- [391] 'gi|15419985|gb|AAK97227.1| CDK-activating kinase [Medicago sativa subsp. x varia]' M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TELDPSKKVADRYLKREVLGEGTYGVVY--------KAID-TQTGQTVAIKKI-----R----IGKQ-------KEGVNFTALREIKLLKEL-K---------DPNIIELI-DCFP--HK-GN-LHLVFEFM-ETDLEAVIRDRNIF--LAPGDIKSYLQMTLKGLAHCHKKWILHRDMKPNNLLIGPN-GQLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLFGTKQYGPGVDVWAAACIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPS-PSQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMVYLPDYVE--YQFVPAPP------LRSL-FPMATDDALDLLSKMF---------------TYDPK----------------DRISVQQALEHRYFTCPP-------------------QPTDPVKLPRPAP-KKEIKPSDLNPP----EGPTVLSPPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTRRVMPGRDGLEGNSLQGDRVDDNHGNLKQTGGDNTGKNEPAPMSLD-FSVFGLKPPNRPTINSADRSHLKRK------LDLEFQ------- [412] 'gi|20194|emb|CAA41172.1| cdc2+/CDC28-related protein kinase [Oryza sativa (japonica cultivar-group)] >gi|266410|sp|P29620|KC47' M-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASGDGGDDAGVKRV---------------ADRYLKREVLGEGTYGVVF--------KAVD-TKTGNTVAIKKI-----R----LGKY-------KEGVNFTALREIKLLKEL-K---------DSNIIELI-DAFP--YK-GN-LHLVFEFM-ETDLEAVIRDRNIV--LSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGAD-GQLKLADFGLARIFGSPE------RNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPK-SSQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMVYLPDYVE--YQFVSAPP------LRSL-FPMASDDALDLLSRMF---------------TYDPK----------------ARITAQQALEHRYFLSVP-------------------APTKPSQLPRPPP-KGDSGNNKIPDLNLQ-DGPVVLSPPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLRRVTAHE-GMEVHMHRADRTEEHPSGAR-HMDDMSSQSSRIPMSVDVGAIFGTRPAPRPTLNSADKSRLKRK------LDMDPEFGYTE-- [424] lcl|Smo_CDKD1_5_1_unnamed_protein_product ?------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVASALQCVTLDGLKMLELKNGIGAKRYVKGISLGEGTYGVVF--------KALD-TQTNRTVAVKKI-----R----LGKY-------KEGVHVTALREIKLLKEL-R---------DPNIIELI-DVYP--HK-RN-LHLVFEFM-ESDLEAVIRDRNIL--LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSD-GQLKLGDFGLARIFGSPD------RKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFQAFGTPR-ETQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTSLPDYVE--FQFTPAPA------LRSL-FPMATEDALDLLSKMF---------------AFDPK----------------ARITAQQALEHRYFSTDP-------------------APTKAHLLLRPAS-KAEGMRPPPELASP--KEPVVLSPPA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARRISLFP-GVAGAEHIHHSKESKDGSSAATVGETPSDHSGMAMSVD------ARMTIRPTLSSTDRSYLKRK------LDMDVHFEDERHV [430] 'gi|15219730|ref|NP 176847.1| CDKD1;2; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k' M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSGDNQPVDRYLRRQILGEGTYGVVY--------KATD-TKTGKTVAVKKI-----R----LGNQ-------KEGVNFTALREIKLLKEL-N---------HPHIVELI-DAFP--HD-GS-LHLVFEYM-QTDLEAVIRDRNIF--LSPGDIKSYMLMTLKGLAYCHKKWVLHRDMKPNNLLIGEN-GLLKLADFGLARLFGSPN------RRFTHQVFATWYRAPELLFGSRQYGAGVDVWAAGCIFAELLLRRPFLPGSTEIDQLGKIFQAFGTPV-PSQWS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMIYLPDYME--FSYTPAPP------LRTI-FPMASDDALDLLAKMF---------------IYDPR----------------QRITIQQALDHRYFSSSP-------------------SPTEPGKLQIPAS-KGDALEPKASEQNQHGNSPAVLSPPG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMRRVMGPE-GFT-------------------------------------------------------------------------------- [348] lcl|Smo_CDKD1_3_1_unnamed_protein_product --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVTLDGLKCLELKNGIGAKRYVTGISLGEGTYGVVF--------KALD-TQTNRTVAVKKI-----R----LGKY-------KEGVHVTALREIKLLKEL-R---------DPNIIELI-DVYP--HK-RN-LHLVFEFM-ESDLEAVIRDRNIL--LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSD-GQLKLGDFGLARIFGSPD------RKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFQAFGTPR-ETQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTSLPDYVE--FQFTPAPA------LRSL-FPMATEDALDLLSKMF---------------AFDPK----------------ARITAQQALEHRYFSTDP-------------------APTKAHLLLRPAS-KAEGMRPPPELASP--KEPVVLSPPA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARRISLFP-GVAGAEHIHHSKESKDGSSAATVGETPSDHSGMAMSVD------ARMTIRPTLS?---------------------------- [400] lcl|Ppa_CDKD1_52_1_unnamed_protein_product -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNRTVAIKKI-----R----LGKL-------KEGVNVTALREIKLLKEL-Q---------DPNIIELI-DVYP--HK-SN-LHLVFEYM-ESDLEAVIRDRNIF--LSPADYKAYMQMILKGLAVCHKKWVLHRDLKPNNLLLGSN-GQLKLADFGLARIFGSPD------RKFTHQVFARWYRAPELLFGSKQYGPGVDVWAAACIFAELILRRPFLQGSSDIDQLGKIFAAFGTPG-KAQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVTSLPDYVE--YQHSPPQS------FRSL-FPQASEDCIDLLQRMF---------------TYDPK----------------RRITAQQALEHRYFRTEP-------------------APTPCHMLRRPS--KPEAQPKPIELLSP--AGHIVFSPPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTRRLQLFG-GDIKTAGEANRDGQAKQQLE---LGTPIDAITIPMSID------PKTNLRPTLNRTLNRSLQVKPSGYANATLSPHSSFTSGF [382] lcl|Ppa_CDKD1_19_1_unnamed_protein_product M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FRAPVDDVVS--------GYMNIGETNRTVAIKKI-----R----LGKL-------KEGVNVTALREIKLLKEL-Q---------DPNIIELM-DVYP--HK-SN-LHLVFEYM-ESDLEAVIRDRNIF--LSSADCKAYMQMILKGLAVCHKKWVLHRDLKPNNLLLGSN-GQLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLFGSKQYGPGVDVWAAACIFAELILRRPFLQGSSDIDQLGKIFGVFGTPG-EAQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVTSLPDYVE--YQYSPPQS------FRSL-FPQASEDCIDLLQRMF---------------TYDPK----------------QRITAQLALEHRYFRTEP-------------------APTPCYMLRRPV--KPEVHPKPIELLSP--AGHIVFSPPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTRRLQLFG-GDIKTAGEASRDTHAKLQPE---LGTPIDAITIPMSID------PKTNLRPTLN?---------------------------- [372] 'gi|55977996|gb|AAV68598.1| CDK activating kinase/cell cycle dependent kinase D [Ostreococcus tauri]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERYERGRTLGEGTYGVVH--------EARV-KETNEVVAIKKI-----R----LGKL-------KEGVNFTAIREIKLLQEI-K---------HEHVIELV-DVFA--HK-KN-LNLVFEYC-GGDLEMVIKDKATP--LSAGEVKSYARMTLRAVAHCHENWVLHRDLKPNNLLIAPN-GCLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLLGSKTYGPGVDVWAVGCILAELMLRKPFFAGSSDIDQLGKVYAALGTPT-ETNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSALPDFIE--FIYVPPPN------LHDT-FPNETNESLDLLKRML---------------EYDPN----------------KRITAAQALEHPYFHTKP-------------------APIPFEELPKRFA-TKNFTQHASGGTSP--SREAKTGEKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLEDADEAP-DSTDPNFRPKPRRRRTGEGVAAVAKGAFGTPPFARRSRGDELKTRRFSPTPLAGN---------------------------- [389] 'gi|68361250|ref|XP 691759.1| PREDICTED: similar to cdc2-related protein p40 MO15 [Danio rerio]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KTTNTIVAIKKI-----K----VGHRTEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDYM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHNHWILHRDLKPNNLLLDEN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPT-DEIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMSSLPDYVS--FKPFPGTP------LEHI-FSAAGDDLLELLRGLF---------------TYNPC----------------SRTTAMQALKMKYFSNRP-------------------GPTPGPQLPRPNS-STEA-LKEKENLLI---GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKR-DSIEQGMSSPSSDNEGQHGHAESDARIAAVPQMSHANMIHTNNPRYHLHPITSNSQSPSSVFHSKQQL-------------------- [399] 'gi|33304107|gb|AAQ02561.1| cyclin-dependent kinase 7 [synthetic construct]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LHHI-FSAAGDDLLDLIQGLF---------------LFNPC----------------ARITATQALKMKYFSNRP-------------------GPTPGCQLPRPNC-PVET-LKEQSNPAL---AI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIFL------------------- [347] 'gi|13529020|gb|AAH05298.1| Cyclin-dependent kinase 7 [Homo sapiens]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHRHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LHHI-FSAAGDDLLDLIQGLF---------------LFNPC----------------ARITATQALKMKYFSNRP-------------------GPTPGCQLPRPNC-PVET-LKEQSNPAL---AI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIF-------------------- [346] 'gi|12654057|gb|AAH00834.1| Cyclin-dependent kinase 7 [Homo sapiens] >gi|4502743|ref|NP 001790.1| cyclin-dependent kinase 7 [Hom' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LHHI-FSAAGDDLLDLIQGLF---------------LFNPC----------------ARITATQALKMKYFSNRP-------------------GPTPGCQLPRPNC-PVET-LKEQSNPAL---AI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIF-------------------- [346] 'gi|83523756|ref|NP 998126.2| hypothetical protein LOC405897 [Danio rerio] >gi|83033260|gb|ABB97084.1| Cdk7 [Danio rerio]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KTTNTIVAIKKI-----K----VGHRTEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDYM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHNHWILHRDLKPNNLLLDEN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPT-DEIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMSSLPDYVS--FKPFPGTP------LEHI-FSAAGDDLLELLRGLF---------------TYNPC----------------SRTTAMQALKMKYFSNRP-------------------GPTPGPQLPRPNS-STEA-LKEKENLLI---GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKR-DSIEQG------------------------------------------------------TLKKKLVF-------------------- [345] 'gi|76646215|ref|XP 869371.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPS------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDFVT--FKSFPGIP------LQHI-FIAAGDDLLDLIQGLF---------------LFNPC----------------TRITATQALKTKYFSNRP-------------------GPTPGCQLPRPNC-PAEA-LKEQSNPAM---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIF-------------------- [346] 'gi|2125816|emb|CAA73587.1| serine/threonine protein kinase [Homo sapiens]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--CKSFPGIP------LHHI-FSAAGDDLLDLIQGLF---------------LFNPC----------------ARITATQALKMKYFSNRP-------------------GPTPGCQLPRPNC-PVET-LKEQANPAL---AI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIF-------------------- [346] 'gi|58176914|pdb|1UA2|D Chain D, Crystal Structure Of Human Cdk7 >gi|58176913|pdb|1UA2|C Chain C, Crystal Structure Of Human Cdk' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAY?HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LHHI-FSAAGDDLLDLIQGLF---------------LFNPC----------------ARITATQALKMKYFSNRP-------------------GPTPGCQLPRPNC-PVET-LKEQSNPAL---AI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEALEQG------------------------------------------------------GLPKKLIF-------------------- [346] 'gi|45768758|gb|AAH68160.1| Cdk7 protein [Mus musculus] >gi|74217064|dbj|BAE26631.1| unnamed protein product [Mus musculus] >gi|' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGVP------LQHI-FIAAGDDLLELIQGLF---------------LFNPC----------------TRTTASQALKTKYFSNRP-------------------GPTPGCQLPRPNC-PVEA-LKEPANPTV---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRAEALEQG------------------------------------------------------ILPKKLIF-------------------- [346] 'gi|34853514|ref|XP 215467.2| PREDICTED: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) [Rattus norve' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLAFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LQHI-FIAAGDDLLELIQGLF---------------LFNPC----------------TRITASQALRTKYFSNRP-------------------GPTPGCQLPRPNC-PVEA-LKEQSNPAM---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRAEALEQG------------------------------------------------------ILPKKLIF-------------------- [346] 'gi|62857669|ref|NP 001017219.1| cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) [Xenopus tropic' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGIMARGVDVRSRSKQYEKLEFLGEGQFATVY--------KARD-KNTDRIVAIKKI-----K----LGHRAEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMSSLPDYVA--FKSFPGTP------LHHI-FIAAGDDLLELLQGLF---------------TFNPC----------------ARCTASQALRKRYFSNRP-------------------APTPGSLLPRPNC-SVEA-LKEQQNLNL---GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEGMDQK------------------------------------------------------DIAKKLNF-------------------- [352] 'gi|68566250|sp|P51952|CDK7 RAT Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor c' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANRNEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------WAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LQHI-FIAAGDDLLELIQGLF---------------LFNPC----------------TRITASQALRTKYFSNRP-------------------GPTPGCQLPRPNC-PVEA-LKEQSNPAM---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRAEALEQ----------------------------------------------------------------------------------- [329] 'gi|619509|emb|CAA58562.1| CdK-activating kinase Cdk7 [Rattus norvegicus] >gi|1083627|pir||S51085 CdK-activating kinase Cdk7 - r' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANRNEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------WAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGIP------LQHI-FIAAGDDLLELIQGLF---------------LFNPC----------------TRITASQALRTKYFSNRP-------------------GPTPGCQLPRPNC-PVEA-LKEQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [312] 'gi|47226698|emb|CAG07857.1| unnamed protein product [Tetraodon nigroviridis]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRSKRYEKLDFLGEGQFATVY--------KARD-KTTDTIVAIKKI-----K----VRHITEA----KDGINRTALREIKLLQEL-H---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHQHWVLHRDLKPNNLLLDGN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRLPFLAGDSDLDQLTKIFEALGTPT-EESWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTSLPDYVS--FKIFPGTP------LEHI-FSAAGDDLLELLQGFF---------------TFNPL----------------MRSTATQALKMRYFSNRP-------------------GPTPGPQLPRPNC-SVEA-LREKETVGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKI----------------------------------------------------------------------------------------- [329] 'gi|64960|emb|CAA37915.1| unnamed protein product [Xenopus laevis] >gi|125413|sp|P20911|CDK7 XENLA Cell division protein kinase' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGIAARGVDVRSRAKQYEKLDFLGEGQFATVY--------KARD-KNTDRIVAIKKI-----K----LGHRAEA----NDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMSSLPDYVA--FKSFPGTP------LHLI-FIAAGDDLLELLQGLF---------------TFNPC----------------ARCTASQALRKRYFSNRP-------------------APTPGNLLPRPNC-SIEA-LKEQQNLNL---GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTEGMDQK------------------------------------------------------DIAKKLSF-------------------- [352] 'gi|395048|emb|CAA52242.1| protein kinase [Mus musculus] >gi|33859522|ref|NP 034004.1| cyclin-dependent kinase 7 (homolog of Xen' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKHNEKLDFLGRGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLELIIKHNSLV--LTPSHIKAYMLMTLQGLEYLHHNWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDYVT--FKSFPGVP------LQHI-FIAAGDDLLELIQGLF---------------LFNPC----------------TRTTASQALKTKYFSNRP-------------------GPTPGCQLPRPNC-PVEA-LKEPANPTV---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRAEALEQG------------------------------------------------------ILPKKLIF-------------------- [346] 'gi|73949665|ref|XP 850424.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQKSSVFSPDCPGLQRPET-KNTHQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMCSLPDFVT--FKSFPGIP------LQHI-FIAAGDDLLDLIQGLF---------------LFNPC----------------TRITATQALKTKYFSNRP-------------------GPTPGCQLPRPNC-PLET-LKEQSNPAV---AT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKRTQALEQG------------------------------------------------------GLPKKLIF-------------------- [354] lcl|4174_Cre_unnamed_protein_product M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AENYVRGALLGQGTFAAVY--------KGSD-KRTGKPVALKEIFPDDKG----GAEG-------KKGLDPTALREIKLLREL-Q---------HEHIIRLM-DAYP--KK-KS-VVLVLEYM-HSDLEAVIKDGNLV--LAAADVKSYMQQLLTALETCHSRWVLHRDIKPNNCLIAPD-GKLKLADFGLSRVYGSPD------GRLTHKVFAPWYRAPELFFGAKQYTSAVDVWAAGCIMGELLLRRPLFDGMSDIEVLAKVFAVCGTPGVDGNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AARDLPYFLQ--FTETKPLP------LRQV-FPAASGDALDLLGRML---------------CLDPQ----------------RRITAAEALAHPYFANNP-------------------PPTPPALLPRPLK-REDAPLASGVAPGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKGRERMSPSASPRPSKAPRRTGPSG------TATPR-------- [353] 'gi|1705720|sp|P51953|CDK7 CARAU Cell division protein kinase 7 (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinas' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKLYEKLDFLGEGQFATVY--------KARD-KTTNTIVAIKKI-----K----VGHRTEA----KDGINRTALREIKLLQEL-S---------HPNIIGLL-DAFG--HK-SN-ISLLC-FM-ETDLEVIIKDTSLV--LTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDEN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLDQLTGIFEALGTPT-EETWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMSNLPDYVS--FKLFPGTP------LEHI-FSAAGDDLLELLKGLF---------------TFNPC----------------TRTTASQALKMRYFSIRP-------------------GPTPGPQLPRPNS-STEA-LKEKENLLI---GI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKR-DSIEQG------------------------------------------------------TLKKKLVF-------------------- [344] 'gi|21295523|gb|EAA07668.1| ENSANGP00000002848 [Anopheles gambiae str. PEST] >gi|31206629|ref|XP 312281.1| ENSANGP00000002848 [A' L-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMEILNRLNRYEKIDFLGEGQFATVY--------KARD-AETNEIVAVKKI-----K----IGNREEA----ADGINRTALREIKLLHEL-Q---------HENIIGLL-DVFG--HK-SN-VSLVFDFM-DTDLEIIIKDPKII--LTPANIKSYMIQTLRGLEYLHQHWILHRDLKPNNLLISGT-GVLKIGDFGLAKFFGSPN------RINTNQVVTRWYRCPELLFGARQYGIGVDIWAVGCILAELLLRVPFLPGESDLDQLTRIFQVLGTPN-ETNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVKSLPDYVQ--YKFYPPIP------LRDI-FTAASDDLIELANKML---------------ALYPL----------------HRCSCTEALKMAYFSNKP-------------------APTVGPRLPMPAS-YNAANSKPEEKPSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKLLDSIDGG------------------------------------------------------TVPKRLQF-------------------- [345] 'gi|1098032|prf||2115201A Mo15 kinase-related protein' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYMIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-K---------HDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTCLPNYIK--FTDHPATP------FKQL-FTAASDEAIDLISKML---------------LFNPS----------------NRISAADALNHPYFTSGV-------------------KHTNPADLPVPFA-KKASLLQQRQVLAQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQQQLLQKQQQQQQQQQQQIQSQPEPIQGDNVEQTQQAQQGKK------------------------ [362] 'gi|7579907|gb|AAB35208.2| Mo15 [Dictyostelium discoideum] >gi|1705721|sp|P54685|CDK7 DICDI Cell division protein kinase 7 (CDK-' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYNIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-K---------HDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTCLPNYIK--FTDHPATP------FKQL-FTAASDEAIDLISKML---------------LFNPS----------------NRISAADALNHPYFTSGV-------------------KHTNPADLPVPFA-KKASLLQQRQVLAQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQVKK------------------------ [362] 'gi|66809013|ref|XP 638229.1| CDC2 family protein kinase [Dictyostelium discoideum] >gi|60466494|gb|EAL64546.1| Mo15 [Dictyostel' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYNIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-K---------HDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTCLPNYIK--FTDHPATP------FKQL-FTAASDEAIDLISKML---------------LFNPS----------------NRISAADALNHPYFTSGV-------------------KHTNPADLPVPFA-KKASLLQQRQVLAQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV-------------------------- [360] 'gi|71021637|ref|XP 761049.1| hypothetical protein UM04902.1 [Ustilago maydis 521] >gi|46100613|gb|EAK85846.1| hypothetical prot' M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETAAAQNLLIANSYAKVEKVGEGTYASVF--------LARS-INTGQKVAIKKI-----K----IVSN-------ENGMDVTAIREVKFLKEL-N---------HPNVIKLV-DVFSSGSRSPS-LNLVLEFL-DTNLEALIKDRTLI--FTQADIKSWMAMLCRGLEYCHRYWVLHRDLKPNNLLISPQ-GELKIADFGLAREHGDPG------ARMTHQVVTRWYRPPELLLGSRAYSSAVDMWSVGCIFAELMLRVPYLPGESDADQLITIFKALGTPT-DKDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHKSLPEYTA--FEQYPKSN------LADL-FLAASPEALDFLQKML---------------LFDPL----------------KRLSANQALHHAYFKQGP-------------------PPTPFKQLPRHPT-KALDSGDPAAHPLL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDSKEKNEVREKQQNQAHGNGNVNGNSRKRPFDAKEIEERRRLARKLAFA------------------- [379] 'gi|57230869|gb|AAW47178.1| cyclin-dependent protein kinase, putative [Cryptococcus neoformans var. neoformans JEC21] >gi|582625' M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLASQENSQRANRWDKGIKIGEGTFANVY--------KGTE-KATGRKVAIKKI-----K----VGEM-------KHGLDMTALREVKFLQEL-K---------HPNIISLL-DVFS--VK-QN-INLVLEFL-DTDLEAVIRDKALI--FQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAAN-GELKIADFGLAREFGDAG------NKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILRVPFLAGETDIDQLKKTFHAMGTPT-EQDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYTKLPDYHE--VGSFPKNP------WWNM-ISSIGREGQDLARELL---------------RFDPA----------------QRPSAKKALLHSFFTSYP-------------------PPTPPIALPKPLA-ELRPRELAPDETQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPLLTSGAGQSLKRKAESPRTSQSVPRKLIFT------------------- [358] 'gi|57230868|gb|AAW47177.1| cyclin-dependent protein kinase, putative [Cryptococcus neoformans var. neoformans JEC21] >gi|582625' M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAQENSQRANRWDKGIKIGEGTFANVY--------KGTE-KATGRKVAIKKI-----K----VGEM-------KHGLDMTALREVKFLQEL-K---------HPNIISLL-DVFS--VK-QN-INLVLEFL-DTDLEAVIRDKALI--FQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAAN-GELKIADFGLAREFGDAG------NKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILRVPFLAGETDIDQLKKTFHAMGTPT-EQDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYTKLPDYHE--VGSFPKNP------WWNM-ISSIGREGQDLARELL---------------RFDPA----------------QRPSAKKALLHSFFTSYP-------------------PPTPPIALPKPLA-ELRPRELAPDETQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPLLTSGAGQSLKRKAESPRTSQSVPRKLIFT------------------- [356] 'gi|54643727|gb|EAL32470.1| GA17354-PA [Drosophila pseudoobscura]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APHSSDKGDRYAKLSFLGEGQFAIVY--------KARD-TVTSQIVAVKKI-----K----RGSREDA----RDGINRTALREIKILQEL-Q---------HENIIGLV-DVFG--QL-SN-VSLVFDFM-DTDLEVIIKDTKII--LTQANIKAYAIMTLRGLEYLHLHWILHRDLKPNNLLVNSD-GVLKIGDFGLAKTYGSPN------RIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFIPGDSDLDQLTRIFATLGTPS-EAEWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLGKLHDYLQ--FRHFTGTP------LENI-FTAADNDLIHLMRRLF---------------AMNPL----------------RRVSCREALSMPYFGNKP-------------------APTVGPKLPLPSA-IVAANAKADEKPGQ---AV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKLVETTVRG---------------------------------------------------NSLPQKKRLQF-------------------- [350] 'gi|66571170|gb|AAY51550.1| IP01401p [Drosophila melanogaster] >gi|17530793|ref|NP 511044.1| Cyclin-dependent kinase 7 CG3319-PA' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPNANDKTERYAKLSFLGEGQFATVY--------KARD-TVTNQIVAVKKI-----K----KGSREDA----RDGINRTALREIKILQEL-Q---------HENIIGLV-DVFG--QL-SN-VSLVFDFM-DTDLEVIIKDNKII--LTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSD-GILKIGDFGLAKSFGSPN------RIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPT-EAEWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLSKLHDYLQ--FRNFPGTP------LDNI-FTAAGNDLIHLMQRLF---------------AMNPL----------------RRVSCREALSMPYFANKP-------------------APTVGPKLPMPSA-ILAAKEGANPQTGDTKPAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKLVETTVRG---------------------------------------------------NGLAQKKRLQF-------------------- [353] 'gi|68474238|ref|XP 718828.1| putative protein kinase [Candida albicans SC5314] >gi|68474409|ref|XP 718744.1| putative protein k' MSTAAV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATKPSVTSKPATKQVSNYTKEKKVGEGTYAVVY--------LGKQ-ISTKRQIAIKEI-----K----TGLF-------KDGLDMSALREVKYLQEL-K---------HPNVIELV-DVFS--AT-NN-LNLVLEFL-PCDLEVLIKDKSIV--FKSADIKSWLLMTLRGIHHCHRNFILHRDLKPNNLLLAPD-GQLKIADFGLARALVNPN------EDLSSNVVTRWYRAPELLFGARHYTGAVDIWSIGIIFAELMLRIPYLPGKDDVDQLDVTFRAYGTPT-EQIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVSSLPMYNA--LHVYPPPS---RQELRNR-FSAATEKALDLLISMT---------------QLDPS----------------RRCDSTLALLHDYFTESP-------------------RPTDPKKLPKKSS-PEKRENEDEQNNGSKRRHV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [343] 'gnl|CMER|CMN139C CDK-activating kinase' M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQPVERYEKQRVLGQGTYGVVY--------LAID-RCTAQPVALKKV-----R----LADY-------TAGLSMTAWRELRLLPELGG---------HPNVIALL-DVFS--TK-SSELYLVYEYC-ETDLEHLITERNLM--LSQGDIKSCLRQLLEGVAACHENWVLHRDLKPSNVLVTTD-GVLKLADFGLARVYAEPDLGTEGGRRMTHQVVTRWYRAPELLFGATAYGPAVDIWAVGCIFAELMRRVPFLPGQNDLDQLGKIAATLGAPT-PDQWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVDALPAYLP--FKSVQRQP------LADL-FRAAPPSAIDLLSRML---------------ALNPN----------------ERISARDALEHAFFHTGA-------------------AESDPRELMVRWR-KAQAHRRAAKTERHS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [328] 'gi|987976|emb|CAA62621.1| Cdk-activating kinase [Schizosaccharomyces pombe] >gi|3150140|emb|CAA19127.1| crk1 [Schizosaccharomyc' MDIEKSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWTYVKERKVGEGTYAVVF--------LGRQ-KETNRRVAIKKI-----K----VGQF-------KDGIDISALREIKFLRES-R---------HDNVIELV-DVFS--TK-SN-LNIILEFL-DSDLEMLIKDKFIV--FQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSD-GVLKLADFGLSRDFGTPS-------HMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRALGTPE-PEVIK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMQQLPNYVE--MKHIPPPN----GGMEAL-FSAAGHEEIDLLKMML---------------DYNPY----------------RRPTAQQALEHHYFSALP-------------------KPTHPSLLPRKGG-EEGIKHVSSDLQRQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNFPMRANIKFV------------------- [335] 'gi|66547195|ref|XP 395800.2| PREDICTED: similar to ENSANGP00000002848 [Apis mellifera]' M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISNTQIFCIIDI-----S----EYNTKNPDGKDRDGINRTALREIKLLQEL-K---------HDNVIGLL-DVFG--HK-SN-VSLVFDFM-DTDLEIIIKDNNIV--LTAANIKAYMIQTLQGLDYLHYNWILHRDLKPNNLLVNAE-GVLKIGDFGLAKFFGSPN------RINTHQVVTRWYRAPELLYGARLYGTGIDMWAVGCILAELLLRVPFLPGESDLDQLTRIFQTLGTPT-EETWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMTELPDFIQ--FKPFPGTP------LKHI-FTAAGDDLLDLIASLL---------------NVNPL----------------ERCTCDQALQMPYFSNKP-------------------APTPGLRLPLPTS-VKRQ---PEEKPSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKLLESMDGA------------------------------------------------------SLAKRLQF-------------------- [316] 'gi|50309219|ref|XP 454616.1| unnamed protein product [Kluyveromyces lactis] >gi|49643751|emb|CAG99703.1| unnamed protein produc' MT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSTVDDYTKEKKAGEGTYAVVY--------LGTK-KSTGRSIAVKEI-----K----TSQF-------KDGLDMSALREVKFLQEL-K---------HVNVIELV-DVFM--AN-DN-LNLVLEFL-PADLEIIIKDTSIM--FSPADIKSWILMTLRGVHHCHRNFILHRDLKPNNLLLAPD-GQLKIADFGLARLMASPQ------EILTSNVVTRWYRAPELLFGAKHYTSAVDIWSVGVIFAELMLRIPYLPGKDDVDQINVTFRALGTPT-DADWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFSNYNK--IQIYPPPS---REELRRR-FIAATENALELISGMM---------------IMNPK----------------KRWDAVKCLQSQYFQELP-------------------EPTLPQDLPKLNK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [310] 'gi|50427707|ref|XP 462466.1| hypothetical protein DEHA0G22528g [Debaryomyces hansenii CBS767] >gi|49658136|emb|CAG90976.1| unna' MASKAA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTATTIVSSPSIAPLKYSKDRKVGEGTYAVVY--------LGNQ-ISTKRKIAIKEI-----K----TGLF-------KDGLDMSAIREVKYLQEL-R---------HPNVIELV-DVFL--TT-NN-LNLVLEFL-PCDLEVLIKDTSIV--FKPSDIKSWLLMTLRGIHHCHRNFILHRDLKPNNLLLAPD-GELKIADFGLARSLGNAD------ELLTSNVVTRWYRAPELLFGARHYTVAVDIWSIGIIFAELMLRTPYLPGKDDTDQIDVTFRALGTPT-EQIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVSNLPLYNA--LRVYPPPS---RQELRNR-FSAATEKALDLLILMT---------------QLDPN----------------RRCDLTQALLHEYFLEFP-------------------RATEPLQLPKKSN-GKEEDSEPENKKRKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [338] 'gi|50761553|ref|XP 424761.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDARARAKRYEKLDFLGEGQFATVY--------KAKD-KNTGQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-S---------HPNVIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSIV--LTQSHIKAYMLMTLQGLEYLHQQWILHRDLKPNNLLLDGN-GVLKLADFGLAKSFGSPN------RVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPLDPLAVTLEISPTSGQTAQDLTIARKGSPNPCCNQSSPAIVDLDDDVSDTHWNAPAEHGFVIRFTRTECALSACRPRTCRRGCPRPHTASARWASRVRRCKFREDGAALTRLSEWVRRWSGCAAGRSETGSRGSAPQPLPAGGRRECRCCPPRLHRSGKGSAGAGAKGAAGLLPFGIGGVLKPGCPGLPACSVLMGEGLRNGTGSGARGPVRICCREGRQLYPLSLSCRSTALTPPAAGLFSVPQHLS--SKR--NAA------LHHTKIPGCEQELLSLKKGLLGCCLTCVFAAPLSVPSDAPCCVFVLPHVSGTGDSMEEKCSLYEVTASNYLQTMPLLLSLPLPSCSLSSTFAVRGTQVECAVPMPVA-MEEV-LGKQGNPGR---NTVVLLVGNVLGPLDGKLKALVYFWFYGCMVILPHGAGHEPPFCLSSEQEGLTRKQRSGRMCIWSWISLDLAMTKACVQGRCRLCVSGAFAAGNVQLVHGLLDLVPLLLPPKFPLRGALACCCGTAACSLCCKCCPKIKQSTSTRFMYALYFILVTIICCVMMSTTVANEMKTHDTKGERLQELNSEKTAEKPWHLSLISGVEARSSSEGVDRE---------------------------------------------------------------------------------- [824] 'gi|39595255|emb|CAE60292.1| Hypothetical protein CBG03876 [Caenorhabditis briggsae]' M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKRYETIRHLGEGQFANVY--------MAKD-LETGEVVAIKKI-----K----LGSREEA----KDGINRTAIREIKLLKEI-H---------HDNIITLR-DVIG--HR-TS-IQLVFDFM-DTDLEHVVKDQSII--LSPSHIKNITMQMLLGMEFLHTHWILHRDLKPNNLLLNNM-GRVKVTDFGLARFFGSPN------RNYTHQVVTRWYRAPELLFGARSYGVGIDIWSIGCIIAELLLRNPIFPGDSDIDQLVKIFNVLGCPT-DESWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMKAMNSYVN--IKPQSETP-----GLNFI-FSAAPQDLIDLMTGMW---------------VFDPV----------------KRLTCTQSLQMEYFRAQP-------------------YCCLDEELPLPNK-KPAKRTRRLEEDGS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPARRLIFD------------------- [329] 'gi|29436789|gb|AAH49499.1| Cyclin-dependent kinase 2 [Danio rerio] >gi|50811836|ref|NP 998571.1| cyclin-dependent kinase 2 [Dan' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFQKVEKIGEGTYGVVY--------KAKN-KVTGETVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLR-DVIH--TE-NK-LYLVFEFL-HQDLKRFMDSTSVSG-ISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQ-GEIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-ESIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------LSKV-VPPLDEDGRDLLGQML---------------TYDPN----------------KRISAKNALVHRFFRDVT-------------------MPVPPLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|21166344|gb|AAK68887.2| Cyclin-dependent kinase family protein 7 [Caenorhabditis elegans] >gi|25145738|ref|NP 490952.2| Cycl' M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRRYDTIKHLGEGQFANVY--------LAQD-LESGECVAIKKI-----K----LGSREEA----KDGINRTAIREIKLLKEI-H---------HDNIIGLR-DVIG--HR-TS-IQLVFDFM-DTDLEHVIKDKEII--LMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKM-GRVKLTDFGLARFFGSPN------RNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPT-PETWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMTEMNSYVI--IKPQTEYM-----ALNYY-FSAAPQDLLDLMAGMW---------------TFDPI----------------KRLTCTQSLQMEYFRTQP-------------------FCCLDEELPLPKKQQPQKRSRRLDDDGT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVRRLNFD------------------- [330] 'gi|51105850|gb|AAT97347.1| GDBD-TEV-Kin28-HA fusion protein [Yeast two-hybrid vector pMK498-TEV]' MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSNYLFDDEDTPPNPKKEIELENLYFQGEFQ---------------------LTTMAMKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-Q---------HPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFMTYNK--LQIYPPPS---RDELRKR-FIAASEYALDFMCGML---------------TMNPQ----------------KRWTAVQCLESDYFKELP-------------------PPSDPSSIKIRNV-MAIPGGGRIFYPYD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDYAGYPYDVPDYAGSYPYDVPDYAAQCGRS-------------------------S------------------- [535] 'gi|51105852|gb|AAT97348.1| GDBD-TEV-CTDx3-Kin28-HA fusion protein [Yeast two-hybrid vector pMK500-TEV]' MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSNYLFDDEDTPPNPKKEIELENLYFQGEFQYSPTSPSYSPTSPSYSPTSPSLTTMAMKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-Q---------HPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFMTYNK--LQIYPPPS---RDELRKR-FIAASEYALDFMCGML---------------TMNPQ----------------KRWTAVQCLESDYFKELP-------------------PPSDPSSIKIRNV-MAIPGGGRIFYPYD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDYAGYPYDVPDYAGSYPYDVPDYAAQCGRS-------------------------S------------------- [556] 'gi|6320095|ref|NP 010175.1| Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcripti' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-Q---------HPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFMTYNK--LQIYPPPS---RDELRKR-FIAASEYALDFMCGML---------------TMNPQ----------------KRWTAVQCLESDYFKELP-------------------PPSDPSSIKIRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [306] 'gi|72006599|ref|XP 783544.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr' M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQRVQ--------RFATVY--------KALDLQHDGKIVAVKKI-----K----LGHRSEA----QDGINRTALREIKLLQEI-K---------HENVIGVIWDPFSANHI-HQ-IELVFFLI-CLLLQVIIKDSSVV--LTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDEN-GVLKIGDFGLAKFYGSPN------RIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFLPGESDLDQLSRIFQTMGTPS-EEEWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMSALADYIE--FKKFPGTP------LRDI-FTAGTDDLLTLLKGLL---------------LMDPC----------------RRCKATEALKMPYFYTKP-------------------APTPGHLLPRPGM-VAAA-ANGKQQPKL---GS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRKMADDIGTG---------------------------------------------------QYSSVNKAYSYS------FEGKSAL------ [346] 'gi|251620|gb|AAB22550.1| cell division kinase; cyclin-dependent kinase; cdk2 [Carassius auratus] >gi|1168865|sp|P43450|CDK2 CAR' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFQKVEKIGEGTYGVVY--------KAKN-KVTGETVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLH-DVIH--TE-NK-LYLVFEFL-HQDLKRFMDSSTVTG-ISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQ-GEIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPD-ESIWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------LSKV-VPPLDEDGRDLLGQML---------------IYDPN----------------KRISAKNALVHRFFRDVT-------------------MPVPPLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|51105854|gb|AAT97349.1| GDBD-TEV-CTDx3-Kin28(E54Q)-HA fusion protien [Yeast two-hybrid vector pMK502-TEV]' MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSNYLFDDEDTPPNPKKEIELENLYFQGEFQYSPTSPSYSPTSPSYSPTSPSLTTMAMKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIRQLKYLQEM-Q---------HPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFMTYNK--LQIYPPPS---RDELRKR-FIAASEYALDFMCGML---------------TMNPQ----------------KRWTAVQCLESDYFKELP-------------------PPSDPSSIKIRNV-MAIPGGGRIFYPYD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDYAGYPYDVPDYAGSYPYDVPDYAAQCGRS-------------------------S------------------- [556] 'gi|47208706|emb|CAF90431.1| unnamed protein product [Tetraodon nigroviridis]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRH-KATGQVVAMKKI-----R----LESE-------EEGVPSTAIREVSLLQEL-K---------HPNVVRLL-EVLM--HD-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMEPMLVKSYLYQILEGILFCHCRRILHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPIDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKS-TFPKWKSGN------LS---VKNLDKDALDLLAKML---------------TYNPP----------------KRISAREAMKHPYFDDLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [289] 'gi|44982328|gb|AAS51637.1| ADL283Wp [Ashbya gossypii ATCC 10895] >gi|45187590|ref|NP 983813.1| ADL283Wp [Eremothecium gossypii]' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVNYTKEKKVGEGTYAVVY--------LGHR-QTDGRQIAIKEI-----K----TSQF-------KDGLDMSAIREVKYLQEI-R---------HANVIELV-DLFM--AQ-EN-LNLVLEFL-PADLEMLIKDSSLL--FTQADIKSWLLMTLRGVHHCHRSFILHRDLKPNNLLLAPD-GQLKIADFGLARTLAAPH------EFMTSNVVTRWYRAPELLFGARHYTAAVDLWSVGVIFAELMLRIPYLPGRDDVDQIDVTFRALGTPT-DKDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFSAYNK--IQVYPPPS---RSELRSR-FIAATENALDLMCGML---------------TMDPH----------------KRWDTTRCLLSQYFVELP-------------------EATPPTELPKLNK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [306] 'gi|11034748|dbj|BAB17220.1| serine/threonine kinase cdc2 [Oryzias javanicus]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAIREVSLLQEL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWKEGS------LSSM-VKNLDKNGLDLLAKML---------------TYNPP----------------KRVSAREAMTHPYFDDLD-------------------KSTLPAASINGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|73946741|ref|XP 533555.2| PREDICTED: similar to cell cycle related kinase isoform 1 [Canis familiaris]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGVVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIED---------NQHVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LVQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCILGELLNGSPLFPGENDIEQLCCVLRILGTPS-PQVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EITELPDYNKISFKEQAPVP------LEEV-LPDASPQALDLLGRFL---------------LYPPH----------------QRISASQALLHQYFFTAP-------------------LPAHPSELPIPQR-PGGPAPKAHSGPPHVHDFRVDRPLEESLLNPELIRPFIPEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|84028813|sp|Q4KM34|CCRK RAT Cell cycle-related kinase' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIED---------SQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPS-PRVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EITELPDYNKISFKEQAPVP------LEEV-LPDASHQALDLLGQFL---------------LYPPR----------------QRIAASQALLHQYFFTAP-------------------LPAHPSELPIPQR-PGGPTPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|21619542|gb|AAH31907.1| Cell cycle related kinase [Mus musculus] >gi|9664926|gb|AAF89089.1| CDK-related protein kinase PNQLA' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIED---------SQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPS-PRVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EITELPDYNKISFKEQAPVP------LEEV-LPDASPQALDLLGQFL---------------LYPPR----------------QRIAASQALLHQYFFTAP-------------------LPAHPSELPIPQR-PGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|1705675|sp|P51958|CDC2 CARAU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1)' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRN-KTTGQVVAMKKI-----R----LESE-------EEGVPSTAVREISLLKEL-Q---------HPNVVRLL-DVLM--QE-SK-LYLVFEFL-SMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NEVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWKSGN------LAST-VKNLDKNGIDLLTKML---------------IYDPP----------------KRISARQAMTHPYFDDLD-------------------KSTLPASNLKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [302] 'gi|55731116|emb|CAH92273.1| hypothetical protein [Pongo pygmaeus] >gi|75070591|sp|Q5R7I7|CCRK PONPY Cell cycle-related kinase' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEMED---------NQYVVQLK-AVFP--HS-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPN-PQVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTELPDYNKISFKEQAPVP------LEEV-LPDASPQALDLLGQFL---------------LYPPR----------------QRIAASKALLHQYFFTAP-------------------LPAHPSELPIPQR-LGVPAPKAHPGPPRIHDFYVDRPLEESLLNPELIRPFILEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|49526555|emb|CAG60179.1| unnamed protein product [Candida glabrata CBS138] >gi|50289629|ref|XP 447246.1| unnamed protein pro' M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAEYTKEKKVGEGTYAVVY--------VGTK-QSTGRRIAVKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-Q---------HVNVIELV-DIFM--SY-GN-LNLVLEYL-PTDLEVVIKDKSIL--FTPADIKSWMLMSVRGVHHCHRNFILHRDLKPNNLLIAPD-GQIKVADFGLARAVPSPH------EVLTSNVVTRWYRAPELLFGAKHYTSAIDVWSLGVIFAELMLRIPYLPGQNDLEQMEVTFRALGTPT-DKDWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSSFNSYNK--LQMYPPPS---RDELRKR-FIAATENALNFMNGMM---------------CLNPA----------------KRWSTAQCLESEYFKELP-------------------RPSDPATIDITRK-E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [307] 'gi|21263450|sp|Q9DG98|CDC2 ORYLU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWKGGS------LSSM-VKNLDKNGLDLLAKML---------------IYNPP----------------KRISAREAMTHPYFDDLD-------------------KSTLPAACINGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|100916|pir||B40444 protein kinase (EC 2.7.1.37) cdc2 homolog B - maize (fragment)' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KTANETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-N---------HGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRNNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQGWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSCLPDFKT-AFPRWQAQD------LATI-VPNLEPAGLDLLSKML---------------RYEPS----------------KRITARQALEHEYFKDLE-------------------MVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [294] 'gi|21263457|sp|Q9DGD3|CDC2 ORYLA Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWKEGS------LSSM-VKNLDKNGLDLLAKML---------------IYNPP----------------KRISAREAMTHPYFDDLD-------------------KSTLPAACINGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|83754642|pdb|2C4G|C Chain C, Structure Of Cdk2-Cyclin A With Pha-533514 >gi|83754640|pdb|2C4G|A Chain A, Structure Of Cdk2-C' G----PLVD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRLERPHR-D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [309] 'gi|21263453|sp|Q9DGA2|CDC2 ORYJA Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWMEGS------LSSM-VKNLDKNGLDLLAKML---------------IYNPP----------------KRISAREAMTHPYFDDLD-------------------KSTLPAACINGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|66805759|ref|XP 636601.1| CDC2-like protein [Dictyostelium discoideum AX4] >gi|60464959|gb|EAL63070.1| CDC2 related protein' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEKYSKIEKLGEGTYGIVY--------KAKN-RETGEIVALKRI-----R----LDSE-------DEGVPCTAIREISLLKEL-K---------HPNIVRLH-DVIH--TE-RK-LTLVFEYL-DQDLKKYLDECGGE--ISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRK-GELKLADFGLARAFGIPV------RTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMASGRPLFPGSGTSDQLFRIFKILGTPN-EESWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SITELPEYKT-DFPVHPAHQ------LSSI-VHGLDEKGLNLLSKML---------------QYDPN----------------QRITAAAALKHPYFDGLE-------------------PIN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [292] 'gi|21263456|sp|Q9DGA5|CDC2 ORYCU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLSRAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKS-TFPKWKGGS------LSSM-VKNLDKNGLDLLAKML---------------IYNPP----------------KRISAREAMTHPYFDDLD-------------------KSTLPAACINGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|76779670|gb|AAI06637.1| Unknown (protein for MGC:132167) [Xenopus laevis]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDGSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSD-GAIKLADFGLARAFGVPV------RTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTTMPDYKS-TFPKWIRQD------FSKV-VPPLDEDGRDLLAQML---------------QYDSN----------------KRISAKVALTHPFFRDVS-------------------RPTPHLI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [297] 'gi|64666|emb|CAA32443.1| Eg1 [Xenopus laevis] >gi|1168866|sp|P23437|CDK2 XENLA Cell division protein kinase 2 (CDC2 homolog Eg1' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDRSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSD-GAIKLADFGLARAFGVPV------RTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTTMPDYKS-TFPKWIRQD------FSKV-VPPLDEDGRDLLAQML---------------QYDSN----------------KRISAKVALTHPFFRDVS-------------------RPTPHLI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [297] 'gi|89903018|ref|NP 001034892.1| cell cycle related kinase isoform 3 [Homo sapiens] >gi|23344742|gb|AAN28684.1| cell cycle relat' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGFPNQALREIKALQEMED---------NQYVVQLK-AVFP--HG-GG-FVLAFEFM-LSDLAEVVRHAQRP--LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPN-PQVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTELPDYNKISFKEQVPMP------LEEV-LPDVSPQALDLLGQFL---------------LYPPH----------------QRIAASKALLHQYFFTAP-------------------LPAHPSELPIPQR-LGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|60652228|gb|AAS59851.2| cyclin-dependent kinase 1 [Anabas testudineus]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYLKIEKIGEGTYGVVY--------KGRH-KATGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQGL-K---------HPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVESLPDYKN-TFPKWKSGN------LASM-VKNLDKNGLDLLAKML---------------TYNPP----------------KRISAREAMTHPYFDDLD-------------------KSTLPAASINKI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [303] 'gi|54043093|gb|AAV28534.1| cell-division-cycle-2 kinase; cyclin-dependent kinase [Saccharum officinarum]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KGLD-KATNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-N---------HDNIVRLH-DVIH--SE-KR-IYLVFEFL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRFLHRDLKPQNLLIDRRTNTLKLADFGLSRAFGIPV------RTFTHEVVTLWYRAPEILLGAKQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSCLPDFKT-AFPRWQAQD------LATI-VPNLEPAGLDLLSKML---------------RYEPS----------------KRITARQALEHEYFKDLE-------------------MVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [294] 'gi|115923|sp|P23111|CDC2 MAIZE Cell division control protein 2 homolog (p34cdc2) >gi|168511|gb|AAA33479.1| protein cdc2 kinase' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KATNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-N---------HGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPN-EQSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSCLPDFKT-AFPRWQAQD------LATV-VPNLDPAGLDLLSKML---------------RYEPS----------------KRITARQALEHEYFKDLE-------------------VVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [294] 'gi|76625139|ref|XP 588152.2| PREDICTED: similar to cell cycle related kinase isoform 1 [Bos taurus]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQVLREIKALQEIED---------SQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHTQRP--LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GNRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCILGELLNGSPLFPGENDIEQLCCVLRILGTPS-PQVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EITELPDYNKISFKEQAPVP------LEEV-LPDASPQALDLLGRFL---------------LYPPQ----------------QRISASQALLHHYFFTAP-------------------LPVHPSELPIPQR-PGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [346] 'gi|50549857|ref|XP 502400.1| hypothetical protein [Yarrowia lipolytica] >gi|49648268|emb|CAG80588.1| unnamed protein product [Y' M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDAVMAKYTKDKKVGEGTFAVVY--------VGKQ-VKTDRKIAIKQI-----K----EGEF-------KDGVDMSAIREIKFLQEI-R---------HANVIELI-DVFT--AG-PR-LSMVLEFL-PTDLEGLIKDTKIL--FRLGDVKAWMLMATRGLHHCHRLQILHRDLKPNNLLISPT-GELKIADFGLARQMPNPK------DKMTPTVVTRWYRAPELLFGARYYTPAVDVWSLGLIFAELMLRLPYCPGEDDIDQIDKTFRAFGTPT-EEEWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTSLPAYPK-TVNKYPHPS---VQELKMR-FSAATENGLELFQAMT---------------ELNPA----------------DRVSCEEALTADYFTEFP-------------------RPTKLAELPGRTE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [310] 'gi|51704177|gb|AAH81346.1| MGC89594 protein [Xenopus tropicalis] >gi|56118390|ref|NP 001008136.1| MGC89594 protein [Xenopus tro' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDGSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTTMPDYKS-TFPKWVRQD------FSKV-VPPLDDDGRDLLAQML---------------QYDSN----------------KRISAKAALTHAFFRDVS-------------------RPTPHLI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [297] 'gi|100915|pir||A40444 protein kinase (EC 2.7.1.37) cdc2 homolog A - maize' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KTANETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-N---------HGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPN-EQSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSCLPDFKT-AFPRWQAQD------LATV-VPNLDPAGLDLLSKML---------------RYEPS----------------KRITARQALEHEYFKDLE-------------------VVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [294] 'gi|50927146|gb|AAH79527.1| Cell division cycle 2 [Danio rerio] >gi|31323425|gb|AAP47014.1| cell division control protein 2 [Dan' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRN-KTTGQVVAMKKI-----R----LESE-------EEGVPSTAVREISLLKEL-Q---------HPNVVRLL-DVLM--QE-SK-LYLVFEFL-SMDLKKYLDSIPSGEFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGASRYSTPVDLWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NEVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVESLPDYKN-TFPKWKSGN------LANT-VKNLDKNGIDLLMKML---------------IYDPP----------------KRISARQAMTHPYFDDLD-------------------KSSLPASNLKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [302] 'gi|72159035|ref|XP 790847.1| PREDICTED: similar to Cell division protein kinase 2 [Strongylocentrotus purpuratus]' MDNGLAHVK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNNFEKIEKIGEGTYGVVY--------KARD-LKSGKTVALKKI-----R----LDTE-------SEGVPSTAIREIALLKEL-D---------HKNIVKLH-DVVH--SD-KK-LYLVFEFM-NQDLKKYMDVAPPSG-LPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDAD-GRIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMITRRALFPGDSEIDQLFRIFRTMGTPD-EKLWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSLPDYKT-SFPRWTPQD------FTKI-VPMLNKDGKDLLKSML---------------CYEPD----------------KRISAKTGLSHPYFKDVK-------------------MV-PPPRLPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [308] 'gi|62460564|ref|NP 001014934.1| cyclin-dependent kinase 2 [Bos taurus] >gi|75070062|sp|Q5E9Y0|CDK2 BOVIN Cell division protein' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAD-GSIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|20343|emb|CAA42922.1| Rcdc2-1 [Oryza sativa (japonica cultivar-group)] >gi|231706|sp|P29618|CDC21 ORYSA Cell division contro' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKEEKIGEGTYGVVY--------RARD-KVTNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-H---------HGNIVRLH-DVIH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGSRQYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSSLPDYKS-AFPKWQAQD------LATI-VPTLDPAGLDLLSKML---------------RYEPN----------------KRITARQALEHEYFKDLE-------------------MVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [294] 'gi|70987446|ref|XP 749136.1| serine/threonine protein kinase [Aspergillus fumigatus Af293] >gi|66846766|gb|EAL87098.1| serine/t' MALSPS---------------------------------------------------------------------------------------------------------------------------------------------------ISQSPSATASSSSAAIKLQAASTGKSVNEEGYAPTLQSDIDRELTELLNEDIQHKYVKDKKLGEGTYAVVY--------LGHLRNDPSSFVAIKKI-----K----VNTEY------KDGLPMDAIREVKYLQEL-S---------HPNIIALH-DVFS--SKDQN-LNLVLEYLPRGDLEMLIKDENIH--YGVADVKAWMGMLARGVWFCHENFVLHRDIKPNNLLIASD-GEVKLADFGLARSFADPY------LNMTHQVITRWYRPPELLYGARQYSGAVDVWSMGMVFAELLLRVPFVAGNSDIDQISKICEAFGTPS-EENWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSTLPNYIP--SDRQSTVPLQGRDFFLRQ-FPTAGPAGADLLMSMC---------------TLDPR----------------KRSTAYQILQHGWWSTEP-------------------RPTAKEDLPRKSG-GTKKMGDDLSRRGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVDDGPFKSAARQLDFM------AVRR--------- [404] 'gi|34809870|pdb|1OIT|A Chain A, Imidazopyridines: A Potent And Selective Class Of Cyclin-Dependent Kinase Inhibitors Identified' --------?----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLSFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [299] 'gi|6166046|sp|Q63699|CDK2 RAT Cell division protein kinase 2 >gi|710025|dbj|BAA05947.1| cyclin dependent kinase 2-alpha [Rattus' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-LPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAE-GSIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|29849|emb|CAA43807.1| CDK2 [Homo sapiens]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGSKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|38197708|gb|AAH61832.1| Cyclin-dependent kinase 2 [Rattus norvegicus] >gi|7949020|ref|NP 058036.1| cyclin-dependent kinase 2' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAE-GSIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|33356961|pdb|1GZ8|A Chain A, Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor 2-Amino-6-(3''-Methyl-2''-Oxo)butoxy' --------?----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLG?KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [299] 'gi|40889309|pdb|1PF8|A Chain A, Crystal Structure Of Human Cyclin-Dependent Kinase 2 Complexed With A Nucleoside Inhibitor' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?ENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|30583821|gb|AAP36159.1| Homo sapiens cyclin-dependent kinase 2 [synthetic construct] >gi|33303947|gb|AAQ02481.1| cyclin-depe' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ [299] 'gi|73968309|ref|XP 856049.1| PREDICTED: similar to cyclin-dependent kinase 2 isoform 6 [Canis familiaris]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KVTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] 'gi|13111756|gb|AAH03065.1| Cyclin-dependent kinase 2, isoform 1 [Homo sapiens] >gi|16936528|ref|NP 001789.2| cyclin-dependent k' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-N---------HPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTSMPDYKP-SFPKWARQD------FSKV-VPPLDEDGRSLLSQML---------------HYDPN----------------KRISAKAALAHPFFQDVT-------------------KPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [298] ; END; BEGIN CODONS; CODESET * UNTITLED = Universal: all ; END; BEGIN ASSUMPTIONS; OPTIONS DEFTYPE=unord PolyTcount=MINSTEPS ; EXSET * UNTITLED = 1-239 250-254 256-259 264-270 289 291-299 308 313-314 317 320 326 329 344-345 386 401 405-411 414 431 478 484-721 732-733 737-738 742-747 750 752 769-783 789-804 823-1168; END; BEGIN MacClade; Version 4.0 87; LastModified -1064065582; FileSettings editor '0' '0' '1' '1'; Singles 100; Editor 00011001111111100100010010 '1' '8' Geneva '14' '744' '1' all; EditorPosition '46' '53' '943' '1601'; TreeWindowPosition '46' '6' '985' '1630'; ListWindow Characters closed Geneva '9' '50' '10' '273' '366' 000; ListWindow Taxa closed Geneva '9' '50' '10' '276' '490' 100000000; ListWindow Trees closed Geneva '9' '50' '10' '276' '490' ; ListWindow TypeSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow WtSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow ExSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow CharSets closed Geneva '9' 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