#NEXUS [MacClade 4.08 registered to Tsuyoshi Aoyama, NIBB] BEGIN DATA; DIMENSIONS NTAX=97 NCHAR=760; FORMAT DATATYPE=PROTEIN SYMBOLS = " 1 2 3 4" MISSING=? GAP=- ; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .] 'gi|30683024|ref|NP 565617.2| CYP711A1; heme binding / iron ion binding / monooxygenase/ oxygen binding [Arabidopsis thaliana]' ------------------------------------------------------------------------------MKTQHQWWEVLDPFLTQHEALIAFLTFAAVVIVIYLYRPS----WSVCNVPGPTAMPLVGHLPLMAKYG-PDVFSVL---AKQYGPIFRFQMGRQPLIIIAEAELCREVGIKK-FKDLPNRSIPSPIS-ASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKP---RDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKD---------------------VEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQV-LKRIPGTMDWRVEKTNARLSGQLNEIVSKR-AKEAE--------TDSKDFLSLILKA-R-ES----------------------------------DPFA-KN----------IFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLD-------------------------QVIKEAMRFYMVSPLV-ARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPE-PEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF------------------------------------------ [522] 'gi|84514179|gb|ABC59098.1| cytochrome P450 monooxygenase CYP711A [Medicago truncatula]' ---------------------------------------------------------------MVFMDLEWL-----------FPIPISVSFASTILA-----LAGGWL--IYLYEPY----WRVRKVPGPPSLPLVGHLHLLAKHG-PDVFSVL---AKQYGPIYRFHMGRQPLIIVADAELCKEVGIKK-FKDIPNRSTPSPIK-ASPLHQKGLFFSRDSQWSTMRNTILSVYQPSHLSRLVPTMQSFIESATQNLDSQK---EDIFFSNLSLKLATDVIGQAAFGVNFGLSQSHSVHNES---KNVATDNKDLMNASGSNEVTDFINQHIYSTTQLKMDLSGSFSIILGLLVPILQEPFRQI-LKRIPGTMDWKIERTNEKLGGRLDEIVEKR-TKDRT--------RSSKDFLSLILNA-R-ES----------------------------------KAVS-EN----------VFTPEYISAVTYEHLLAGSATTSFTLSSVVYLVAAHPEVEKKMLEEIDGYGSLDQIPTSQDLHDKFPYLD-------------------------QVIKEAMRFYIVSPLV-ARETSNEVEIGGYLLPKGTWVWLALGVLAKDHKNFPE-PEKFKPERFDPNCEEMKQRHPYAFIPFGIGPRACIGQKFSMQEIKLSLIHLYKKYLFRHSADMESPLELEYGIVLNFKHGVKFSVIKRTEMSC-------------------------------------- [541] 'gi|19699353|gb|AAL91286.1| At2g26170/T19L18.2 [Arabidopsis thaliana] >gi|15810030|gb|AAL06942.1| At2g26170/T19L18.2 [Arabidopsi' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKP---RDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKD---------------------VEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQV-LKRIPGTMDWRVEKTNARLSGQLNEIVSKR-AKEAE--------TDSKDFLSLILKA-R-ES----------------------------------DPFA-KN----------IFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLD-------------------------QVIKEAMRFYMVSPLV-ARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPE-PEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF------------------------------------------ [384] 'gi|34911504|ref|NP 917099.1| cytochrome P450-like protein [Oryza sativa (japonica cultivar-group)]' --------------------------------------------------------------------MEIIST---------VLGS-TAEYAVTLVA-----MAVGLLLLGYLYEPY----WKVRHVPGPVPLPFIGHLHLLAMHG-PDVFTVL---ARKYGPVFRFHMGRQPLVMVADAELCKEVGVKK-FKSIPNRSMPSAIA-NSLINQKGLCFTRGSRWTALRNMIISIYQPSHLASLIPTMQSCIECVSKNLDGQ----EDITFSDLALGFATDVIGQAAFGTDFGLSKISASSNDD-DIDKIATDTSAEAKAS-----SEFIRMHVHATTSLKMDLSGSLSIIIGQLLPFLQEPFRQV-LKRIPWTADHEIDHVNLALGGQMDKIVAER-AAAMERDQAAPHAQQRKDFLSVVLAA-R-ES----------------------------------NKSW-RE----------LLTPDYISALTYEHLLAGSATTAFTLSTVLYLVSKHPEVEEKLLREIDGFGPHDHAPTAEDLQTKFPYLD-------------------------QVVKESMRFYFLSPLI-ARETCEQVEIGGYALPKGTWVWLAPGVLAKDPKNFPE-PEVFRPERFDPNGEEEKRRHPYAFIPFGIGPRACIGQKFSIQEIKLSVIHLYRNYVFRHSPSMESPLEFQYSIVCNFKYGVKLRVIKRHTA---------------------------------------- [541] 'gi|53793263|dbj|BAD54486.1| putative thromboxane-A synthase [Oryza sativa (japonica cultivar-group)]' --------------------------------------------------------------------MEAL-----------VAAAAAAARDQPWLLLPWSWLAGVVVVVVYFYAPW----WGVRRVPGPAALPVVGHLPLLAAHG-PDVFAVL---AKKYGPIFRFHLGRQPLVIVAEAELCKEVGIRQ-FKSIANRSLPAPIA-GSPLHQKGLFFTRDARWSAMRNTIISLYQPSHLAGLIPTMHSCVARAADAIAAAEQ--RDVDFSDLSLKLATDVIGQAAFGVDFGLTAAAAAAPRS-------DDADADGGEA-----AEFIREHVHSTTSLKMDLSGSLSIVLGLVAPALQGPARRL-LSRVPATADWRTARANERLRARVGAVVARR-ERAGGEA-----RRARRDFLSAVLNA-R-DG----------------------------------GSDRMRA----------LLTPDYVGALTYEHLLAGSATTAFTLSSAVYLVAGHPGVEAKLLDEVDRFGPPDAVPTADDLEHKFPYLD-------------------------QVIKEAMRFYTVSPLI-ARETSEQVEVGGYTLPKGTWVWLAPGVLSRDEAQFRD-AGEFRPERFDAGGEEERRRHAYAHVPFGLGPRACPGRRFALQEVKLAMAHLYRRFVFRRSPRMESPPELQFGMVLSFRRGVKLTAVERRHAAAA------------------------------------- [540] 'gi|34911506|ref|NP 917100.1| cytochrome P450-like protein [Oryza sativa (japonica cultivar-group)]' --------------------------------------------------------------------MD-ISE---------VLGA-TAEWAVTLVA-----MAVGLLVVAYLYEPY----RKVWHVPGPVPLPLIGHLHLLAMHG-PDVFSVL---ARKHGPVFRFHMGRQPLIIVADAELCKEVGVKK-FKSIPNRSMPSPIA-NSPIHKKGLFFIRGPRWTSMRNMIISIYQPSHLASLIPTMESCIQRASKNLDGQ----KEITFSDLSLSLATDVIGLAAFGTDFGLSKLPVTPDDS-NIDKIAADTSVEAKAS-----SEFIKMHMHATTSLKMDLSGSLSILVGMLLPFLQEPFRQV-LKRIPGMGDYKIDRVNRALKTHMDSIVAER-EAAMEHDLAA--SQQRKDFLSVVLTA-R-ES----------------------------------NKSS-RE----------LLTPDYISALTYEHLLAGSTTTAFTLSTVLYLVAKHPEVEEKLLKEIDAFGPRYCVPMADDLQTKFPYLD-------------------------QVVKESMRFYIMSPLL-ARETLEQVEIGGYVLPKGTWVWLAPGVLAKDPKNFPE-PEIFRPERFDPNGEEERRRHPYAFIPFGIGPRVCIGQKFSIQEIKLSMIHLYRHYVFRHSPSMESPLEF-------------------------------------------------------------- [516] 'gi|34911498|ref|NP 917096.1| cytochrome P450-like protein [Oryza sativa (japonica cultivar-group)]' --------------------------------------------------------------------ME-IST---------VLGAILAEYAVTLVA-----MAVGFLVVGYLYEPY----WKVRHVPGPVPLPLIGHLHLLAMHG-PDVFSVL---TRKYGPIFRFHMGRQPLVMVADAELCKEVGVKK-FKNFPNRSMPSPIT-NSPVHQKGLFFTSGSRWTTMRNMILSIYQPSHLATLIPSMESCIERAAENLEGQ----EEINFSKLSLSFTTDVLGQAAFGTDFGLSKKLASSDDDEDTRKIAADTCAEAKAS-----SEFIKMHVHATTSLKMDMSGSLSIIVGQLLPFLHEPFRQV-LKRLRWTADHEIDRVNLTLGRQLDRIVAER-TAAMKRDPAA--LQQRKDFLSVMLTA-R-ES----------------------------------NKSS-RE----------LLTPDYISALTYEHLLAGSATTAFTLTTALYLVAKHPEVEEKLLREIDGFGPRDRVPTAEDLQTKFPYLDQARQTLPRRVYIVRHEFLTAHRARMQVLKEAMRYYPSSPLI-ARELNQQLEIGGYPLPKGTWVWMAPGVLGKDPKNFPE-PEVFRPERFDPNGEEEKRRHPYALFPFGIGPRACIGQKFAIQEMKLSAIHFYRHYVFRPSPSMESPPEFVYSIVSNFKNGAKLQVIKRHI----------------------------------------- [564] 'gi|50906431|ref|XP 464704.1| putative thromboxane-A synthase [Oryza sativa (japonica cultivar-group)] >gi|46806524|dbj|BAD17637' --------------------------------------------------------------------------MEASNCSIALEISHVATPGLPVLLLGSS-LALLAVFLVYFYAPF----WSLRTVPGPPTRFPIGHLHLLAKNG-PDVFRAI---TKEYGPIFRFHMGRQPLVIVANAELCKEVGIKK-FKDIRNRSTPPPNV--GTLHQDALFLTRDSTWSSMRNMVIPLYQPARLAGLIPTMQSYVDALVDNIAGCPDQ-DCIPFCQLSLCMAIDIIGKTAFGIEFGLSRKAADTAAG-----------DDGDGDDDDDVKEFLREYKKSMEFIKMDLSSSLSTILGLFLPCVQTPCKRL-LRRVPGTADYKMDQNERRLCRRIDAIIAGR-RRDRDAG-----DGAALDFIAALLDA-R-ES----------------------------------GGGG-HG--------GFALEDRHVRALAYEHLIAGTKTTAFTVSSVVYLVSCHPRVEERLLREIDGFAPRGRVPGADELHAGLPYLN-------------------------QVIKEAMRFHLVSPLI-ARETSEPVEIAGHLLPKGTYVWLAPGVLARDAAQFPE-PEEFRPERFAAGAAEERARHPYAHIPFGIGPRACVGHRFALQQVKLAAVGLYRRYVFRHSPAMESPLQFDFDLVLAFRHGVKLRAIKRTNT---------------------------------------- [543] 'gi|50906433|ref|XP 464705.1| putative thromboxane-A synthase [Oryza sativa (japonica cultivar-group)] >gi|51963956|ref|XP 50676' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCVYCNAGI---------FGG-----------------------VRDSTWSSMRNMVIPLYQPARLAGLIPTMQSYVDALVDNIAGCPDQ-DCIPFCQLSLCMAIDIIGKTAFGIEFGLSRKAADTAAG-----------DDGDGDDDDDVKEFLREYKKSMEFIKMDLSSSLSTILGLFLPCVQTPCKRL-LRRVPGTADYKMDQNERRLCRRIDAIIAGR-RRDRDAG-----DGAALDFIAALLDA-R-ES----------------------------------GGGG-HG--------GFALEDRHVRALAYEHLIAGTKTTAFTVSSVVYLVSCHPRVEERLLREIDGFAPRGRVPGADELHAGLPYLN-------------------------QVIKEAMRFHLVSPLI-ARETSEPVEIAGHLLPKGTYVWLAPGVLARDAAQFPE-PEEFRPERFAAGAAEERARHPYAHIPFGIGPRACVGHRFALQQVKLAAVGLYRRYVFRHSPAMESPLQFDFDLVLAFRHGVKLRAIKRTNT---------------------------------------- [423] lcl|Smo_MAX1_12_2_unnamed_protein_product ?KKGEKEKTSIWTEENKKYKLYKQRSIKNFRLKTQHRTAYQPRRAGKQDNKGEEKCK--RNSPQIDKGDDGVEMDGAQRCQHRDPAQNAAAHGLQMALIIAVFFVIVVTILIYLQWPA----WKLSKIPAAPYISGLGHLPLMAKYQ-AGVFIKL---AKQLGPIYRFQLGRQPIVFVASADLCQEIAIRK-FKVFPNRVILPYMK-ESWIHLHGLFMTKAPDWARMRNILLPTFHTEKLSAYVPLMERVMGQVVEILDKHANAGEDVNMTQLLQRMALDVIGESAFGTGFKLVKPSWADGRS--------------------EDKDMVNAVLNSLDTLTMSEKAP-------------HPIREI-MKRIPGTGDWNQYTGNLLLEAQMRALLERR-EAEMRDG------VVRSDALSLLLDA-R-A-----------------------------------KSQEMRE----------LLTDERVLALAYELMMAGSESTGTNLCYTLYFIAAHPEVASKMVKEIDELAPLGSTVAFEDVDK-FKYVD---QSVNDQ----------------QVIKESMRMITFSPVV-AREAMEDIKVVGYHIPKGTWVWLVINALAQDEEDFPE-PHLFRPERFDPDCAEAKKRHPYAHSPFGIGPRMCIGYKLAYLEMKLALIHFYQRYTFEHSPAMENPLAVRLSIVVRPIHGVKLRVRKRGIC---------------------------------------- [598] lcl|Smo_MAX1_213_1_unnamed_protein_product ---------------------------------TQYRTAYQPRRAGKQDNKGEEKCKYLRNSPQIDEGDDGVKMDGAQRCQHRDPAQNAAAHGLQMALIIAVFFVILVTILIYLQWPA----WKLSKIPAAPYISGLGHLPLMAKYQ-AGVFIKL---AKQLGPIYRFQLGRQPIVFVASADLCQEIAIRK-FKVFPNRVILPYMK-ESWIHLHGLFMTKAPDWARMRNILLPTFHTEKLSAYVPLMERVMGQVVEILDKHANAGEDVNMTQLLQRMALDVIGESAFGTGFKLVKPSWADGRS--------------------EDKDMVNAVLNSLDTLTMNEKAP-------------HPIREI-MKRIPGTGDWNQYTGNLLLEAQMRALLERR-EAEMRDG------VVRSDALSLLLDA-R-A-----------------------------------KSQEMRE----------LLTDERVLALAYELMMAGSESTGTNLCYTLYFIAAHPEVASKMVKEIDELAPLGSTVAFEDVDK-FKYVDQPLQSVNDQ----------------QVIKESMRMITFSPVV-AREAMEDIKVAGYHIPKGTWVWLVINALAQDEEDFPE-PHLFRPERFDPDCAEAKKRHPYAHSPFGIGPRMCIGYKLAYLEMKLALIHFYQRYTFEHSPAMENPLAVRLSIVVRPIHGVKLRVRKREIC---------------------------------------- [570] 'gi|47522908|ref|NP 999211.1| thromboxane synthase [Sus scrofa] >gi|1351234|sp|P47787|THAS PIG Thromboxane-A synthase (TXA synth' --------------------------------------------------------------------MEVLG----------FLSPELNGPMVTMA------LAVVLLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLTFFRQGF-WESHMEL---RKQYGPLSGYYLGRRMIVVISDPDMIKQVLAEK-FSNFTNRMATG--L-ESKPVADSILFLRDKRWEEVRSVLTSAFSPKKLNKLTPLISQACDLLLAHLERYAESGDAFDIQRCYCCYTTDVVASVAFGTQVNSSEEPE---------------------------HPFVK---HCRRFFAFSVP-RLILVLILSFPSIMVPLARILPNKKRD-------EVNGFFNKLIRNVIALRDQQAAE--------ERRQDFLQMVLDL-R-HSAPSVGVENFDIVRQAFSSA----KGCPADPSQPHLPRPLSK----------PLTVDEVVGQAFLFLIAGYEIITNTLSFVTYLLATNPDCQEKLLREVDDFSKKHPSPEHCSLQQGLPYLD-------------------------MVLSETLRMYPPAFRF-TREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHWPH-PETFDPERFTAEAQR--LQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPETQVPLQLESKSALSPKNGVYIRIVPR------------------------------------------- [534] 'gi|76615849|ref|XP 871574.1| PREDICTED: similar to Thromboxane-A synthase (TXA synthase) (TXS) isoform 2 [Bos taurus]' --------------------------------------------------------------------MEVLG----------LFRLEVSGPMVTVA------LSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQGF-WESHMEL---RKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEK-FSNFTNRMATG--L-EPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERHAQSGEAFDIQRTYCCYTTDVVASVAFGTEVNSQEAPE---------------------------HPFVE---HCRRFFASSIP-KPLLVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVQDV-R-HSAATVGVENFDIVRQVFSAT----K-CPANPPRRHLPRPLSK----------PLSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCSLQEGLPYLD-------------------------MVIKETLRMYPPAFRF-TRVAAQDCEVLGQRIPAGAVLETAVGALHYDPEHWPN-PENFNPERFTAEAQQ--RRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFRFEACPETQVPLQLESKSALGPKNGVYIRIVSR------------------------------------------- [533] 'gi|86438168|gb|AAI12648.1| Unknown (protein for MGC:137614) [Bos taurus]' --------------------------------------------------------------------MEVLG----------LFRLEVSGPMVTVA------LSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQGF-WESHMEL---RKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEK-FSNFTNRMATG--L-EPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERHAQSGEAFDIQRTYCCYTTDVVASVAFGTEVNSQEAPE---------------------------HPFVE---HCRRFFASSIP-KPLLVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVQDV-R-HSAATVGVEKFDIVRQVFSAT----K-CPANPPRRHSPRPLSK----------PLSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCSLQEGLPYLD-------------------------MVIKETLRMYPPAFRF-TRVAAQDCEVLGQRIPAGAVLETAVGALHYDPEHWPN-PENFNPERFTAEAQQ--RRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFRFEACPETQVPLQLESKSALGPKNGVYIRIVSR------------------------------------------- [533] 'gi|73978856|ref|XP 539887.2| PREDICTED: similar to Thromboxane-A synthase (TXA synthase) (TXS) [Canis familiaris]' --------------------------------------------------------------------MEVLS----------FLKLEVNGPMVTVA------LSVVLLALLKWYSTAAFSRLEKLGIRHPKPSPFIGNLPFFCQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FHNFTNRMVSG--L-ESKPVMDSVLFLRDKRWEEVRSVLTSAFSPEKLNEMTPLISQACDLLLAHLKHYAESGDAFDIQRCYSCYTTDVVASVAFGTQVDSRRAPG---------------------------DPFVK---HCRRFFAYSIP-RPILVLILSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQLILDA-R-HLATSLGVDSFDMVRQVFSST----D-CTVGPSRPHQPRHLSQ----------PLTLDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLAEVDSFKEKYTALDYCSLQEGLPYLD-------------------------MVIAETLRIYPPAFRF-TREAARDCEVRGQRIPAGAVVEVAVGALHRDPEYWPQ-PETFNPERFKAEAQR--RQQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLQVLHQFRFEACPETQVPLQLDSKSALGPKNGIYIKIVSR------------------------------------------- [533] 'gi|84578983|dbj|BAE72925.1| hypothetical protein [Macaca fascicularis]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLMFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQACDLLLAHLKRYAESGDAFDIQRCYRNYTTDVVASVAFGTPVDSQQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPVGVQDFDMVGDVFSST----R-CKPNPSRQHQAGPMAR----------PLTVDEIVGQAFIFLIAGYEIVTNTLSFATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEAQQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFQFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|62898664|dbj|BAD97186.1| thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) isoform TXS-I variant [' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|1085400|pir||S48161 thromboxane-A synthase (EC 5.3.99.5) - human' --------------------------------------------------------------------MEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQIVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCGLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|34223719|sp|P24557|THAS HUMAN Thromboxane-A synthase (TXA synthase) (TXS)' --------------------------------------------------------------------MEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|9800404|gb|AAF99273.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACELLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800406|gb|AAF99274.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPSKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800410|gb|AAF99276.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAEDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800412|gb|AAF99277.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PKTFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800416|gb|AAF99279.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|1325919|dbj|BAA07011.1| thromboxane synthase [Homo sapiens]' --------------------------------------------------------------------MEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|4507383|ref|NP 001052.1| thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) isoform TXS-I [Homo sap' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|2828213|sp|P36423|THAS MOUSE Thromboxane-A synthase (TXA synthase) (TXS) (TS) >gi|79750133|ref|NP 035669.3| thromboxane A sy' --------------------------------------------------------------------MEVLG----------LLKFEVSGTIVTVT------LLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGF-WESQLEL---RERYGPLCGYYLGRRMHVVISEPDMIKQVLVEN-FSNFSNRMASG--L-EPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPE---------------------------DPFVQ---HCRRASTFCIP-RPLLVLILSFPSIMVPLARILPNKNRD-------ELNGFFNTLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-Q-HSMNSVGVEGFDMVPESLSSS----E-CTKEPPQRCHPTSTSK----------PFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLD-------------------------MVISETLRMYPPAFRF-TREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPN-PETFDPERFTAEARL--QRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|9800402|gb|AAF99272.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFHQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800414|gb|AAF99278.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PENFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|9800408|gb|AAF99275.1| thromboxane synthase [Homo sapiens]' -------------------------------------------------------------------MMEALG----------FLKLEVNGPMVTVA------LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGF-WESQMEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [534] 'gi|15559502|gb|AAH14117.1| TBXAS1 protein [Homo sapiens]' --------------------------------------------------------------------------------------------------------------------------------------------------------MEL---RKLYGPLCGYYLGRRMFIVISEPDMIKQVLVEN-FSNFTNRMASG--L-EFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE---------------------------DPFVK---HCKRFFEFCIP-RPILVLLLSFPSIMVPLARILPNKNRD-------ELNGFFNKLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-R-HSASPMGVQDFDIVRDVFSST----G-CKPNPSRQHQPSPMAR----------PLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLD-------------------------MVIAETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPS-PETFNPERFTAEARQ--QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [466] 'gi|37589372|gb|AAH59313.1| MGC68990 protein [Xenopus laevis]' --------------------------------------------------------------------MEMLR----------LWGL--DGCTVTFA------LVAGFLGLVYWYSVSAFSQLEKVGIKHPKPLPFIGNVMLFQKGF-WEGDRHL---LKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKD-FVNFTNRMKFN--L-ATKPMSDSLLCLRDDKWKRVRSVLTPSFSAIRMKEMCPLINQCCDVLVDNLQEYASSGEACNVQRCYACFTMDVVASVAFGTQVDSQKDPE---------------------------HPLVQ---NCKRFLEQFTPFKPLVLLCLAFPSIMIPIARRLPNKQRD-------RINSFFLKVIRDIIAFRENQPPN--------ERRRDFLQLMLDA-R-DSAGHVTVDHFDIVNQADLSVPRNSP-SEKQDRGQDSPRKSTK----------KLNEEEILGQAFIFLIAGYETTCSLLSFASYLLATHPECQKKLLREVDEFGREHKEADYNTVHE-LPYME-------------------------MVINETLRMYPPAYRF-AREAARDCTVMGLNIPAGAVVEIPIGCLQNDPRFWHE-PEKFNPERFTAEEKQ--KRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRILKNFRFQTCDLTQIPLQLSAMSTLRPKDGVYVRVVAR------------------------------------------- [535] 'gi|20809428|gb|AAH29014.1| Thromboxane A synthase 1, platelet [Mus musculus]' --------------------------------------------------------------------MEVLG----------LLKFEVSGTIVTVT------LLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGF-WESQLEL---RERYGPLCGYYLGRRMHVVISEPDMIKQVLVEN-FSNFSNRMASG--L-EPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLMAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPE---------------------------DPFVQ---HCRRASTFCIP-RPLLVLILSFPSIMVPLARILPNKNRD-------ELNGFFNTLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-Q-HSMNSVGVEGFDMVPESLSSS----E-CTKEPPQRCHPTSTSK----------PFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLD-------------------------MVISETLRMYPPAFRF-TREAAQDCEVLGQRIPAGAVLEIAVGALHHDPEHWPN-PETFDPERFTAEARL--QRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|181372|gb|AAA35744.1| cytochrome P-450 nifedipine oxidase' --------------------------------------------------------------------MALIP----------------DLAMETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [503] 'gi|76667917|dbj|BAE45352.1| cytochrome P450 3A [Macaca fuscata]' --------------------------------------------------------------------MDLIP----------------DLAVETWL------LLAVTLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNILSYRKGF-WTFDMEC---YKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITIFPFIIPILEVLNISIFPR-------EVTSFLRKSVKRIKESR-LKDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRIFPIAMRL-ERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWPE-PEKFLPERFNKKNND--NIDPYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGT--------------------------------VSGA---- [503] 'gi|35911|emb|CAA30944.1| unnamed protein product [Homo sapiens] >gi|117156|sp|P08684|CP3A4 HUMAN Cytochrome P450 3A4 (Quinine 3' --------------------------------------------------------------------MALIP----------------DLAMETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [503] 'gi|66731517|gb|AAY51971.1| cytochrome P450 3A4v2 [Cercopithecus aethiops]' --------------------------------------------------------------------MDLIP----------------DLAVETWL------LLAVTLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNVLSYRKGF-WQFDMEC---YKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNLRRETETGKPVTMKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITIFPFLIPILEVLNISIFPR-------KVTSFLRKSVKRIKESR-LKDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRIFPIAMRL-ERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWAE-PEKFLPERFSKKNND--NIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGT--------------------------------VSGA---- [503] 'gi|6981634|ref|NP 036819.1| thromboxane A synthase 1 [Rattus norvegicus] >gi|1351235|sp|P49430|THAS RAT Thromboxane-A synthase' --------------------------------------------------------------------MEVLG----------LLKFEVSGTVVTVT------LSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGF-WESHLEL---RERYGPLCGYYLGRRMYIVISDPDMIKEVLVEN-FSNFSNRMASG--L-EPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPE---------------------------DPFVQ---HCQRVFAFSTP-RPLLALILSFPSIMVPLARILPNKNRD-------ELNGFFNTLIRNVIALRDKQTAE--------ERRGDFLQMVLDA-Q-RSMSSVGVEAFDMVTEALSSA----E-CMGDPPQRCHPTSTAK----------PLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLD-------------------------MVVAETLRMYPPAFRF-TREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPN-PETFDPERFTAEARL--QQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR------------------------------------------- [533] 'gi|66731515|gb|AAY51970.1| cytochrome P450 3A4v1 [Cercopithecus aethiops]' --------------------------------------------------------------------MDLIP----------------DLAVETWL------LLAVTLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNVLSYRKGF-WQFDMEC---YKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNLRRETETGKPVTMKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITIFPFLIPILEVLNISIFPR-------KVTSFLRKSVKRIKESR-LKDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRIFPIAMRL-ERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWAE-PEKFLPERFSKKNND--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGT--------------------------------VSGA---- [503] 'gi|37681955|gb|AAQ97855.1| thromboxane A synthase 1 [Danio rerio] >gi|45387645|ref|NP 991172.1| thromboxane A synthase 1 [Danio' ----------------------------------------------------------------MQLLVDGLK----------WFGVEASGLSLTVC------LFLLFLSLLYWYSISPFSNLERCGIKHPKPLPFIGNLMMFRNGF-FKSQADL---INKYGRICGYYIGRRSTVIIADPDMLRQVMVKE-FNKFPNRMTAR--G-ITKPMSDSLIMLKGEQWKRVRSILTPTFSAAKMKEMVPLINTATETLLRNLKSHAESENSFNIHKCFGCFTMDVIASVAFGTQVDSQNNPD---------------------------DPFVH---QASKFFAFSFF-RPIMIFFMAFPFLLRPLAGLLPNKSRD-------EMNSFFTQCIQKMIKQRDDLSPE--------QRRKDFLQLMLDV-R-TNNKFLSVEHFDVVNDADEEAYDGHENSPANEST--KRSQQKR----------MMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHEMVDYANVQE-LKYLD-------------------------MVICESLRLYPPAFRV-ARDVEEDTVLNGQFLPKGASLEIPTGFLHYDPEHWTE-PTKFIPERFTPEAKA--RRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTEIPLELKSHTTLGPKNGVMVKITERENL--------------------------------EDAS---- [546] 'gi|6644372|gb|AAF21034.1| cytochrome P450 IIIA4 [Homo sapiens] >gi|11177455|gb|AAG32290.1| cytochrome P450 polypeptide 4 [Homo' --------------------------------------------------------------------MALIP----------------DLAMETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [503] 'gi|76654208|ref|XP 888251.1| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 isoform 3 [Bos taurus]' --------------------------------------------------------------------MELIL----------------SFSTETWV------LLATGLVLLYLYGTYSYGLFKKLGVPGPRPLPYFGNILSYRKGV-CEFNEEC---FKKYGKIWGIFEGKQPLLVITDPDMIKTVLVKECYSVFTNRRVF---G-PSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKEMFPIIGKYGDVLVRNLRKEAEKGTSVDIKDIFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NVKKLLRFSIL-DPFLLAVVLFPFLVPILDVLNITIFPK-------SAVNFFTKSVKRIKESR-LKDNQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHKEPLEK-----TLSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAIRL-ERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLKVVLRDGT--------------------------------ISGA---- [508] 'gi|76654204|ref|XP 584699.2| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 isoform 1 [Bos taurus]' --------------------------------------------------------------------MELIL----------------SFSTETWV------LLATGLVLLYLYGTYSYGLFKKLGVPGPRPLPYFGNILSYRKGV-CEFNEEC---FKKYGKIWGIFEGKQPLLVITDPDMIKTVLVKECYSVFTNRRVF---G-PSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKEMFPIIGKYGDVLVRNLRKEAEKGTSVDIKDIFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NVKKLLRFSIL-DPFLLAVVLFPFLVPILDVLNITIFPK-------SAVNFFTKSVKRIKESR-LKDNQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHK----------ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAIRL-ERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLKVVLRDGT--------------------------------ISGA---- [503] 'gi|76654210|ref|XP 888253.1| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 isoform 4 [Bos taurus]' --------------------------------------------------------------------MELIL----------------SFSTETWV------LLATGLVLLYLYGTYSYGLFKKLGVPGPRPLPYFGNILSYRKGV-CEFNEEC---FKKYGKIWGIFEGKQPLLVITDPDMIKTVLVKECYSVFTNRRVF---G-PSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKEMFPIIGKYGDVLVRNLRKEAEKGTSVDIKDIFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NVKKLLRFSIL-DPFLLAVVLFPFLVPILDVLNITIFPK-------SAVNFFTKSVKRIKESR-LKDNQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHKDSIFK-----TLSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAIRL-ERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLKVVLRDGT--------------------------------ISGA---- [508] 'gi|6166034|sp|P11707|CP3A6 RABIT Cytochrome P450 3A6 (CYPIIIA6) (P450-3C) >gi|164830|gb|AAA31178.1| cytochrome p-450' --------------------------------------------------------------------MDLI------------------FSLETWV------LLAASLVLLYLYGTSTHGLFKKMGIPGPTPLPFIGTILEYRKGI-WDFDIEC---RKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSF---G-PVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKGKPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQ---------------------------DPFVK---NVRRLLKFSFF-DPLLLSITLFPFLTPIFEALHISMFPK-------DVMDFLKTSVEKIKDDR-LKDKQ--------KRRVDFLQLMINS-Q-NS----------------------------------KEIDSHK----------ALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVK-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHWTE-PDEFRPERFSKKNKD--NINPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSRDGI--------------------------------IRGA---- [501] 'gi|33114052|gb|AAP94642.1| cytochrome P450 3A64 [Macaca mulatta] >gi|263693|gb|AAB24952.1| cytochrome P-450 3A; P-450 3A [Macac' --------------------------------------------------------------------MDLIP----------------DLAVETWL------LLAVTLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNILSYRKGF-WTFDMEC---YKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITIFPFIIPILEVLNISIFPR-------EVTSFLRKSVKRIKESR-LKDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRIFPIAMRL-ERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWPE-PEKFLPERFSKKNND--NIDPYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGT--------------------------------VSGA---- [503] 'gi|46394978|gb|AAS91645.1| cytochrome P450 3A64 variant 1; CYP3A64 [Macaca mulatta]' --------------------------------------------------------------------MDLIP----------------DLAVETWL------LLAVTLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNILSYRKGF-WTFDMEC---YKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITIFPFIIPILEVLNISIFPR-------EVTSFLRKSVKRIKESR-LKDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRIFPIAMRL-ERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWPE-PEKFLPERFSKKNND--NIDPYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGT--------------------------------VSGA---- [503] 'gi|910|emb|CAA38687.1| cytochrome P-450 [Canis familiaris] >gi|55742760|ref|NP 001003340.1| cytochrome P-450 3A12 [Canis famili' --------------------------------------------------------------------MDLIP----------------SFSTETWL------LLAISLVLLYLYGTYTHGIFRKLGIPGPTPLPFVGTALGYRNGF-YVFDMKC---FSKYGRMWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRTL---G-PVGFMKSAISLSEDEEWKRMRTLLSPTFTTGKLKEMFPIIGQYGDVLVNNLRKEAEKGKAINLKDVFGAYSMDVITSTSFGVNIDSLNHPQ---------------------------DPFVE---NTKKLLKFDFL-DPFFFSILLFPFLTPVFEILNIWLFPK-------KVTDFFRKSVERMKESR-LKDKQ--------KHRVDFLQLMINS-Q-NS----------------------------------KEMDTHK----------ALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNKALPTYDALVQ-MEYLD-------------------------MVLNETLRLYPIAGRL-ERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE-PEEFRPERFSRKNKD--SINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLKVEPRDGS--------------------------------VNGA---- [503] 'gi|6470135|gb|AAF13598.1| cytochrome P450-3A4 [Homo sapiens]' --------------------------------------------------------------------MALIP----------------DLAMETRL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [503] 'gi|3913302|sp|O18993|CP3AL CALJA Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10) >gi|2388529|dbj|BAA22156.1| cytochrome P-450 [' --------------------------------------------------------------------MDFIP----------------NLAVETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGTVLYYRQGF-WKFDMEC---YKKYGKMWGIYDGRQPVLAITDPNIIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAQDDEWKRIRSLLSPTFTSGKLKEMVPIIAQYGEVLVRNLRREAEKGKPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQ---------------------------DPFVE---STKKLLRFDFL-DPFFLSITIFPFLTPILEALNISMFPR-------DSTSFLRKSIKRIKESR-LKDTH--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESDK----------ALSDLELVAQSIIFIFAGYETTSSTLSFIMYELATHPDVQQKLQEEIDAVLPNKAPATYDTVLQ-MEYLD-------------------------MVVNETLRLFPLAMRL-ERVCKKDVEINGVFIPKGVVVMIPSYALHYDPKYWTE-PEKFLPERFSKNNKD--NIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKVEPRDGT--------------------------------VSGA---- [503] gi|510086|gb|AAA35747.1|_cytochrome_P450_nifedipine_oxidase --------------------------------------------------------------------MAVIP----------------DLAMETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVCGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSI-IFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [502] 'gi|30840237|emb|CAD91343.1| cytochrome P450 [Homo sapiens]' --------------------------------------------------------------------MDLIP----------------NFAMETWV------LVATSLVLLYIYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [503] 'gi|73957820|ref|XP 536868.2| PREDICTED: hypothetical protein XP 536868 [Canis familiaris]' --------------------------------------------------------------------MDLIP----------------SFSMETWL------LLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGF-SVFDENC---FRKYGRMWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSF---G-PVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEAEKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NIKKLLKFDFL-DPFFFSILLFPFLTPVFEVLNIWLFPK-------SVTDFFTKSVKRMKENR-LKDKQ--------KHRVDFLQLMINS-Q-NS----------------------------------KETDTHK----------ALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNKALPTYDALVQ-MEYLD-------------------------MVLNETLRLYPIAGRL-ERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE-PEEFRPERFSRKNKD--SINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLKVEPRDGS--------------------------------VNGA---- [503] 'gi|117155|sp|P05184|CP3A3 HUMAN Cytochrome P450 3A3 (CYPIIIA3) (HLp) >gi|181354|gb|AAA35742.1| glucocorticoid-inducible cytochr' --------------------------------------------------------------------MALIP----------------DLAMETWL------LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKLVLVKECYSVFTNREPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLNNPQ---------------------------DPLVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKAVKRMKESR-LEDTQ--------KHRVDFLQLMIDSHK-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [504] 'gi|51247968|pdb|1W0G|A Chain A, Crystal Structure Of Human Cytochrome P450 3a4 >gi|51247967|pdb|1W0F|A Chain A, Crystal Structu' ----------------------------------------------------------------------------------------------------------------MAYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGAHHHH [485] 'gi|51247719|pdb|1TQN|A Chain A, Crystal Structure Of Human Microsomal P450 3a4' ---------------------------------------------------------------------------------------------------------------MALYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGF-CMFDMEC---HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGAHHHH [486] 'gi|76654206|ref|XP 888247.1| PREDICTED: similar to Cytochrome P450 3A4 (Quinine 3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase' --------------------------------------------------------------------MELIL----------------SFSTETWV------LLATGLVLLYLYGTYSYGLFKKLGVPGPRPLPYFGNILSYRKGV-CEFNEEC---FKKYGKIWGIFEGKQPLLVITDPDMIKTVLVKECYSVFTNRRVF---G-PSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKEMFPIIGKYGDVLVRNLRKEAEKGTSVDIKDIFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NVKKLLRFSIL-DPFLLAVVLFPFLVPILDVLNITIFPK-------SAVNFFTKSVKRIKESR-LKDNQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHKGNQGELQRGHTLSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAIRL-ERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLKVVLRDGT--------------------------------ISGA---- [513] gi|165574|gb|AAA31430.1|_cytochrome_P450_3c_protein --------------------------------------------------------------------MDLI------------------FSLETWV------LLAASLVLLYLYGTSTHGLFKKMGIPGPTPLPFIGTILEYRKVINWDFDIEC---RKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSF---G-PVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKASPSTLKEIFGAYSMDVITGTSFGVNIDSLRNPQ---------------------------DPFVK---NVRRLLKFSFF-DPLLLSITLFPFLTPIFEALHISMFPK-------DVMDFLKTSVEKIKDDR-LKDKQ--------KRRVDFLQLMINS-Q-NS----------------------------------KEIDSHK----------ALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVK-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKKDVDINGTFIPKGTIVM-PTYALHRDPQHWTE-PDEFRPERFSKKNKD--NINPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSESGI--------------------------------IRGA---- [501] 'gi|66730479|ref|NP 001019403.1| cytochrome P450, subfamily 3A, polypeptide 62 [Rattus norvegicus] >gi|24898925|dbj|BAC23085.1|' --------------------------------------------------------------------MDLIP----------------NISLETWM------LLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNILAYRHGF-WEFDRHC---HKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF---G-PAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQ---------------------------NPFVQ---KVKKLLKFNFL-DPFFLSVILFPFLTPVFEAFDITVFPK-------DVMKFFRTSVERMKENR-MQEKV--------KQRLDFLQLMINS-Q-SS----------------------------------GDKESHQ----------GLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAALPNKAPVTYDVLVE-MEYLD-------------------------MVLNETLRLFPVGGRL-ERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPE-PEEFCPERFRKKNQD--SINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD------------------------------------------ [497] 'gi|24181973|gb|AAN47145.1| cytochrome P450 3A26 [Canis familiaris] >gi|50979182|ref|NP 001003338.1| cytochrome P450 3A26 [Canis' --------------------------------------------------------------------MDLIP----------------SFSTETWL------LLAISLVLLYLYGTYTHGIFRKLGIPGPTPLPFVGTALGYRNGF-YVFDMKC---FSKYGRMWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRTL---G-PVGFMKSAISLSEDEEWKRIRTLLSPTFTTGKLKEMFPIIGQYGDVLVNNLRKEAEKGKAINLKDVFGAYSMDVITSISFGVNIDSLNHPQ---------------------------DPFVE---NTKNLLKFDFL-DPFLFSILLFPFLTPVFEILNIWLFPK-------KVTDFFRKSVERMKESR-LKDKQ--------KHRVDFLQLMINS-Q-NS----------------------------------KEMDTHK----------ALSDLELVAQSIVFIFAGYETTSSCLSFLMYELATHRDVQQKLQEEIDATFPNKAAPTYEALVQ-MEYLD-------------------------MVLNETLRLYSVAGRL-ERVCKKDVEISGVFIPKGTVVMVPTFILHRDQNLWPE-PEEFRPERFSRKNKD--SINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKSCKETQISLRINTRGIIQPEKPVVLKVEPRDGS--------------------------------VSGA---- [503] 'gi|74354642|gb|AAI02567.1| Unknown (protein for MGC:127840) [Bos taurus]' --------------------------------------------------------------------MELIP----------------NFSVETWV------LLAISLVLLYLYGTYSHGLFKKLGVPGPRPLPLFGNVLSYRKGV-CEFDEEC---FKKYGKMWGIFEGKHPLLVITDPDMIKTVLVKECYSVFTNRRVF---G-PMGVMKNAVSVAEDEQWKRIRTLLSPTFTSGKLKEMFPIIGKYGDVLVRNLRKEAEKGTSVDMKEVFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NAKKLLRFDIL-DPFLLSVVLFPFLIPIFEVLNISIFPK-------SAVNFLTTSVKKIKESR-LKDTQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHK----------ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAVRL-ERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQIPLKIKSQGLLRPEKPIVLKVVLRDET--------------------------------ISGA---- [503] 'gi|1698440|gb|AAB87704.1| thromboxane synthase [Mus musculus]' --------------------------------------------------------------------MEVLG----------LLKFEVSGTIVTVT------LLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGF-WESQLEL---RERYGPSVWVLSWPSIDVVISEPDMIKQVLVEN-FSNFSNRMASG--L-EPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPE---------------------------DPFVQ---HCRRASTFCIP-RPLLVLILSFPSIMVPLARILPNKNRD-------ELNGFFNTLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-Q-HSMNSVGVEGFDMVPESLSSS----E-CTKEPPQRCHPTSTSK----------PFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLD-------------------------MVISETLRMYPPAFRF-TREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPN-PETFDPERFTAEARL--QRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|484439|pir||JN0683 thromboxane-A synthase (EC 5.3.99.5) - mouse' --------------------------------------------------------------------MEVLG----------LLKFEVSGTIVTVT------LLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGF-WESQLEL---RERYGPSVWVLSWPAIDVVISEPDMIKQVLVEN-FSNFSNRMASG--L-EPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKPYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPE---------------------------DPFVQ---HCRRASTFCIP-RPLLVLILSFPSIMVPLARILPNKNRD-------ELNGFFNTLIRNVIALRDQQAAE--------ERRRDFLQMVLDA-Q-HSMNSVGVEGFDMVPESLSSS----E-CTKEPPQRCHPTSTSK----------PFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLD-------------------------MVISETLRMYPPAFRF-TREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPN-PETFDPERFTAEARL--QRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR------------------------------------------- [533] 'gi|49066337|gb|AAT49270.1| cytochrome P450 CYP3A66 [Macaca mulatta]' --------------------------------------------------------------------MDLIP----------------NLAMETWL------LLAVSLVLLYLYGTRSYGLFKRQGIPGPTPLPFLGNILSYRQGL-WKFDTEC---YKKYGKMWRTQDGQLPVLTITDPEMIKTVLVKECYSVFTNRRPL---G-PVGLMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDMLVRNLRREAEKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPK---------------------------DPFVE---SVKKFLKFDFL-DPLFLLTILFPFLTPAFEALNVSLFPK-------DAINFLNKSVNSMKKSR-LNDKQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDAVLPNKAPATYDAMVQ-MEYLD-------------------------MVVNETLRLFPIAIRL-ERACKKDVEINGVFIPKGAMVVIPTYALHHDPKYWTE-PEEFRPERFSKKNKD--SIDPYIYTPFGTGPRNCIGMRFALMNMKLAIIKVLQNFSFKPCKETQIPLKLGNQGLLQSEKPIVLKVESRDGT--------------------------------LSGE---- [503] 'gi|37748668|gb|AAH60001.1| Unknown (protein for MGC:68549) [Xenopus laevis]' --------------------------------------------------------------------MEEPT----------LWGL--DGCTVTFA------LVAGFLGLLYWYSVSAFSQLDKVGIKHPKPLPFIGNVMLFKKGF-WEGDRHL---IKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKD-FVNFTNRMKLN--L-VTKPMSDSLLCLRDDKWKRVRSVMTPSFSAIRMKEMCPLINQCCDVLVDNLLEYASSGEACNVQRCYACYTMDVVASVAFGTQVDSQRDPD---------------------------HPLVQ---NCKRFLELFTPFKPLILLCLAFPSIMIPIARRLPNKQRD-------RINSFFLKVIRDIIAFRENQPPN--------ERRRDFLQLMLDA-Q-DSVSHVTVDHFDIVNQADLSVPQNSP-SEKQDRGQDPPRKSSK----------KLNKEEILGQAFIFLIAGYETTCSLLSFTSYLLATHPDCQEKLLKEVDEFSQEHKEADYNTVHD-LPYMD-------------------------MVINETLRMYPPAYRF-AREAARDCTVMGQNIPAGAVVEIPIGCLQNDPRFWHE-PEKFNPERFTAEEKQ--KRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRVLQKFRFQTCDLTQIPLQLSAMSTLRPKDGVYVTVVAR------------------------------------------- [535] 'gi|2493370|sp|Q29496|CP3AO SHEEP Cytochrome P450 3A24 (CYPIIIA24) >gi|1381232|gb|AAB02657.1| cytochrome P450 CYP3A24' --------------------------------------------------------------------MELIP----------------SFSLETWV------LLAISLVLLYLYGTYSHGLFKKLGVSGPRPLPYFGNVLSYRKGV-CEFDEEC---FKKYGKMWGVFEGKQPLLVITDPDVIKTVLVKECYSVFTNRRVF---G-PMGIMKNAVSVAEDEQWKRIRTLLSPTFTSGKLKDMFPIIGKYGDVLVRNLRKEAEKGKSVNMKDIFGAYSMDVITSTSFGVNIDSLGNPQ---------------------------DPFVE---NAKKLLRFNIL-DPFLLSVVLFPFLVPIFEVLNITMFPK-------SAVDFLTKSVKRIKESR-LKDNQ--------KPRVDFLQLMINS-Q-NS----------------------------------KETDNHK----------ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQ-MEYLD-------------------------MVVNETLRMFPIAVRL-DRLCKKDVEIHGVSIPKGTAVTVPIFVLHRDPQLWPE-PEEFRPERFSKKNKD--SINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKINSQGLIRPEKPIFLKVVLRDET--------------------------------ISGA---- [503] 'gi|56270307|gb|AAH86985.1| Cytochrome P450, family 3, subfamily a, polypeptide 13 [Rattus norvegicus]' --------------------------------------------------------------------MDLIP----------------NFSMETWL------LLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGF-WEFDKYC---HKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNF---G-PVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQ---------------------------DPFVE---KIKKLLKFDIF-DPLFLSVTLFPFLTPLFEALNVSMFPR-------DVIDFFKTSVERMKENR-MKEKE--------KQRMDFLQLMINS-Q-NS----------------------------------KVKDSHK----------ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQ-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPE-PEEFRPERFSKKNQD--NINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDET--------------------------------VNGA---- [503] 'gi|22219436|ref|NP 671739.1| cytochrome P450, family 3, subfamily a, polypeptide 13 [Rattus norvegicus] >gi|1276918|gb|AAC52582' --------------------------------------------------------------------MDLIP----------------NFSMETWL------LLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGF-WEFDKYC---HKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNF---G-PVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQ---------------------------DPFVE---KVKKLLKFDIF-DPLFLSVTLFPFLTPLFEALNVSMFPR-------DVIDFFKTSVERMKENR-MKEKE--------KQRMDFLQLMINS-Q-NS----------------------------------KVKDSHK----------ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQ-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPE-PEEFRPERFSKKNQD--NINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDET--------------------------------VNGA---- [503] 'gi|47523898|ref|NP 999587.1| cytochrome P450 3A39 [Sus scrofa] >gi|4151927|gb|AAD04628.1| cytochrome P450 [Sus scrofa]' --------------------------------------------------------------------MDLIP----------------GFSTETWV------LLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYFGNILGYRKGV-DHFDKKC---FQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSF---G-PRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQ---------------------------DPFVE---NSKKLLKFSFF-SPLFLSIIFFPFLTPILEVLNVTLFPK-------SVVNFFMRSIKRMKESR-LKDKQ--------THRVDFLQLMINS-Q-NS----------------------------------KETDTHK----------GLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEEIDATFPSKALPSYDALAQ-MEYLD-------------------------MVVNEILRLYPIAARL-ERVCKKDVEIHGVSVPKGTVMMVPVFSIHRDPELWPE-PEEFRPERFSKKNKD--SINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGT--------------------------------VGGA---- [503] 'gi|1408198|gb|AAB03662.1| cytochrome P450olf3 [Rattus norvegicus] >gi|2506240|sp|P51538|CP3A9 RAT Cytochrome P450 3A9 (CYPIIIA9' --------------------------------------------------------------------MDLIP----------------NFSMETWL------LLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGF-WEFDKYC---HKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNF---G-PVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQ---------------------------DPFVE---KVKKLLKFDIF-DPLFLSVTLFPFLTPLFEALNVSMFPR-------DVIDFFKTSVERMKENR-MKEKE--------KQRMDFLQLMINS-Q-NS----------------------------------KVKDSHK----------ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQ-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPE-PEEFRPERFSKKNQD--NINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDET--------------------------------VNGA---- [503] 'gi|1769424|emb|CAA71266.1| cytochrome P450 [Bos taurus] >gi|5921920|sp|P79102|CP3AS BOVIN Cytochrome P450 3A28 (CYPIIIA28)' --------------------------------------------------------------------MELIP----------------SFSMETWV------LLATSLVLLYIYGTYSYGLFKKLGIPGPRPVPYFGSTMAYHKGI-PEFDNQC---FKKYGKMWGFYEGRQPMLAITDPDIIKTVLVKECYSVFTNRRIF---G-PMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKEMFPIIGQYGDMLVRNLRKEAEKGNPVNMKDMFGAYSMDVITGTAFGVNIDSLNNPH---------------------------DPFVE---HSKNLLRFRPF-DPFILSIILFPFLNPVFEILNITLFPK-------STVDFFTKSVKKIKESR-LTDKQ--------MNRVDLLQLMINS-Q-NS----------------------------------KEIDNHK----------ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNKAPPTYDALVQ-MEYLD-------------------------MVVNETLRMFPIAGRL-ERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPE-PEEFRPERFSKNNKD--SINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQIPLKLYTQGLTQPEQPVILKVVPRGLG--------------------------------PQVEPDFL [507] 'gi|66731519|gb|AAY51972.1| cytochrome P450 3A7 [Cercopithecus aethiops]' --------------------------------------------------------------------MALIP----------------DLAMETWL------LLAVSLILLYLYGTHSHGLFKKLGIPGPTPLPFFGNVLSFHKGL-WTFDMEC---YKKYRKVWGFYDCLQPVLAITDPNMIKTVLVKECYSVFTNRRPL---G-PVGFMKSALSRAQDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDIFGAYSMDVITSTSFGVNVDSLNNPQ---------------------------DPFVE---NTKKLLRFNSL-DPFFLSIKIFPFLTPIFEALNITMFSR-------KVTNFLRKSVNKIKEDR-LKETQ--------KRRVDFLQLMIDS-Q-NS----------------------------------KDTESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQKEIDAVLPNKAPPTYDTVLQ-MEYLH-------------------------MVVNETLRLFPVAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKHWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLRFGGLLQPEKPIVLTAESRNGT--------------------------------VSGA---- [503] 'gi|89886134|ref|NP 776956.2| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 [Bos taurus] >gi|88954366|gb|' --------------------------------------------------------------------MELIP----------------SFSMETWV------LLATSLVLLYIYGTYSYGLFKKLGIPGPRPVPYFGSTMAYHKGI-PEFDNQC---FKKYGKMWGFYEGRQPMLAITDPDIIKTVLVKECYSVFTNRRIF---G-PMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKEMFPIIGQYGDMLVRNLRKEAEKGNPVNMKDMFGAYSMDVITGTAFGVNIDSLNNPH---------------------------DPFVE---HSKNLLRFRPF-DPFILSIILFPFLNPVFEILNITLFPK-------STVDFFTKSVKKIKESR-LTDKQ--------MNRVDLLQLMINS-Q-NS----------------------------------KEIDNHK----------ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKVQEEIDATFPNKAPPTYDALVQ-MEYLD-------------------------MVVNETLRMFPIAGRL-ERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPE-PEEFRPERFSKNNKD--SINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQIPLKLYTQGLTQPEQPVILKVVPRGLG--------------------------------PQVEPDFL [507] 'gi|74202077|dbj|BAE23029.1| unnamed protein product [Mus musculus] >gi|74202021|dbj|BAE23008.1| unnamed protein product [Mus mu' --------------------------------------------------------------------MDLIP----------------NFSMETWM------LLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQKGF-WECDIQC---HKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF---G-PVGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQ---------------------------DPFVE---KIKKLLKFDIF-DPLFLSVTLFPFLTPVFDALNVSLFPR-------DVISFFTTSVERMKENR-MKEKE--------KQRVDFLQLMINS-Q-NY----------------------------------KTKESHK----------ALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQ-MEYLD-------------------------MVVNETLRLYPIAGRL-ERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPE-PEEFRPERFSKKNQD--SINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPENPLLLKVVSRDET--------------------------------VSDE---- [503] 'gi|6166035|sp|Q64417|CP3AE CAVPO Cytochrome P450 3A14 (CYPIIIA14) >gi|736702|dbj|BAA08568.1| cytochrome P450 [Cavia porcellus]' --------------------------------------------------------------------MDLVP----------------SFSLETWV------LLALSLVLLYRYATYSHGFFKKLGIPGPKPLPLFGNVLSYRKGM-WSFDIEC---RKKYGNMWGLYDGPQPVLAITEPDMIKAVLVKECYSVFTNRRSL---V-PVGFMKKAVSLSEDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGAYSMDIIVATAFGVNVDSLNNPH---------------------------DPFVS---KARKLFRFDFL-SPFLLSIVMFPFLTQLYEMLSISIFPR-------DSLKFFTKFVKKTKENH-LESNK--------KQRVDFLQMMLNS-Q-NF----------------------------------KDTESHK----------ALSDVEILAQSIIFIFAGYETTSSTLSFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMME-MEYLD-------------------------MVVNETLRLYPVTNRI-ERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE-PDEFRPERFSKKNKE--NIDPYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSFYPCKETQIPLRLGSEALLQPAKPIILKVVSRDET--------------------------------IRGA---- [503] 'gi|303570|dbj|BAA03865.1| cytochrome P450 [Cavia porcellus]' --------------------------------------------------------------------MDLVP----------------SFSLETWV------LLALSLVLLYRYATYSHGFFKKLGIPGPKPLPLFGNVLSYRKGM-WSFDIEC---RKKYGNMWGLYDGPQPVLAITEPDMIKAVLVKECYSVFTNRRSL---V-PVGFMKKAVSLPEDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGAYSMDIIVATAFGVNVDSLNNPH---------------------------DPFVS---KARKLFRFDFL-SPFLLSIVMFPFLTQLYEMLSISIFPR-------DSLKFFTKFVKKTKENH-LESNK--------KQRVDFLQMMLNS-Q-NF----------------------------------KDTESHK----------ALSDVEILAQSIIFIFAGYETTSSTLSFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMME-MEYLD-------------------------MVVNETLRLYPVTNRI-ERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE-PDEFRPERFSKKNKE--NIDPYIYMPFGNGPRNCIGMRMALMNIKLALIRLLQNFSFYPCKETQIPLRLGSEALLQPAKPIILKVVSRDET--------------------------------IRGA---- [503] 'gi|4503233|ref|NP 000756.1| cytochrome P450, family 3, subfamily A, polypeptide 7 [Homo sapiens] >gi|45709445|gb|AAH67436.1| Cy' --------------------------------------------------------------------MDLIP----------------NLAVETWL------LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGY-WTFDMEC---YKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQ---------------------------DPFVE---NTKKLLRFNPL-DPFVLSIKVFPFLTPILEALNITVFPR-------KVISFLTKSVKQIKEGR-LKETQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KDSETHK----------ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQ-LEYLD-------------------------MVVNETLRLFPVAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDET--------------------------------VSGA---- [503] 'gi|40316434|dbj|BAD06180.1| cytochrome P450 [Sus scrofa domestica]' --------------------------------------------------------------------MDLIP----------------SFSVETWL------LLATSLVLLYLYGTYSHGLFKKLGIPGPKPLPYLGSVLEYRKGM-WHFDNKC---FKKYGKMWGFYDGRQPVLAMRDPEMIKAVLVKECYSAFTNRRNF---G-PAGVMKNAISVAKDEQWKRVRTLLSPTFTSGKLKEMFPIIAQYGDMLVRNLRKEAEKGNSINTKEIFGAYSMDVITSTAFGVDVDSLNNPR---------------------------DPFVQ---YARKLLRFDFL-DPFILSIILFPFLSPFFEVLDITLFPR-------SSVKFFTQSVKRMKESR-LKDQQ--------MRRVDLLQLMINS-Q-NS----------------------------------KETDAHK----------ALSDQELVAQSIIFICAGYETTSSSLSFLAYILATHPDVQQNLQEEIDATFPSKALPSYDALAQ-MEYLD-------------------------MVVNEILRLYPIAARL-ERVCKKDVEIHGVSVPKGTVMMVPVFSIHRDPELWPE-PEEFRPERFSKKNKD--SINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGT--------------------------------VSGA---- [503] 'gi|12082809|gb|AAG48618.1| cytochrome P450 variant 3A7 [Homo sapiens]' --------------------------------------------------------------------MDLIP----------------NLAVETWL------LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGY-WTFDMEC---YKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQ---------------------------DPFVE---NTKKLLRFNPL-DPFVLSIKVFPFLTPILEALNITVFPR-------KVISFLTKSVKQIKEGR-LKETQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KDSETHK----------ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQ-LEYLD-------------------------MVVNETLRLFPVAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETFVDMEPIHMDFLRSLAFQGPHLCFFWELLCPTIRSR---- [535] 'gi|73958043|ref|XP 546969.2| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 [Canis familiaris]' --------------------------------------------------------------------MDLIP----------------SFSTETWL------LLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGF-CDFDEKC---FRKYGRMWGFYDGRQPVLAIMDPDMIKTVLVKECYSVFTNRRSF---G-PVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEAEKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NAKKLLKFDFP-DPFLLSIILFPFLTPLYEMLNIWLFPK-------KITDFFTKSVKRMKESR-LKDKQ--------KHRVDFLQLMINS-Q-NS----------------------------------KEMNTHK----------ALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQQKLQKEIDATFPNKAAPTYDTLVQ-MEYLD-------------------------MVLNESLRLYPITGRL-VRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE-PEKFQPERFSKKNKD--SINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILNVEPRDGS--------------------------------VRGA---- [503] 'gi|90110014|sp|P24462|CP3A7 HUMAN Cytochrome P450 3A7 (CYPIIIA7) (P450-HFLA)' --------------------------------------------------------------------MDLIP----------------NLAVETWL------LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGY-WTFDMEC---YKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQ---------------------------DPFVE---NTKKLLRFNPL-DPFVLSIKVFPFLTPILEALNITVFPR-------KVISFLTKSVKQIKEGR-LKETQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KDSETHK----------ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQ-LEYLD-------------------------MVVNETLRLFPVAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWRE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDET--------------------------------VSGA---- [503] 'gi|5921913|sp|Q64406|CP3AF CAVPO Cytochrome P450 3A15 (CYPIIIA15) >gi|688410|dbj|BAA05498.1| cytochrome P450 [Cavia porcellus]' --------------------------------------------------------------------MDLIP----------------SFSLETWV------LLALSLVLLYQYATYSHGFFKKLGIPGPKPLPLFGNVLSYRKGM-WSFDIEC---RKKYGNMWGLYDGPQPVLAITEPDMIKAVLVKECYSVFTNRRSL---V-PVGFMKKSVSLSEDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGAYGMDIIIATAFGVNVDSLNNPH---------------------------DPFVS---KANKLFRFDFL-SPFLLSTVMFPFLTQLYEMLSISIFPR-------DSLKFFTKFVKKTKENH-LESNK--------KQRVNFLQMMLNS-Q-NF----------------------------------KDTESHK----------ALSDVEILAQSIIFIFAGYETSSSTLSCIMYSLATHPDVQKKLHQEIDKTLPNKAFPTYDVMME-MEYLD-------------------------MVVNETLRLYPVANRI-ERMSKKDFEINGMSFPKGTLVMIPSFALHRDSKYWPE-PDEFRPERFSKKNKE--NIDPYIYMPFGNGPRNCIGRRMALMNLKLALIRLLQNFSFYPCKETQIPLRLSSEALLQPEKPLILKVVSRDET--------------------------------IRGA---- [503] 'gi|1060881|dbj|BAA05873.1| cytochrome P450 [Cavia porcellus] >gi|5921915|sp|Q64409|CP3AH CAVPO Cytochrome P450 3A17 (CYPIIIA17)' --------------------------------------------------------------------MDLIP----------------SFSLETWV------LLALSLVLLYQYATYSHGFFKKLGIPGPKPLPLFGNVLSYRKGI-WNFDIEC---HKKYGNMWGLYDGPRPVLSITEPDMIKAVLVKECYSVFTNRRSI---F-PAGFMKKALSISKDEEWKRIRTQLSQNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGAYSMDIIIATAFGVNVDSLNNPH---------------------------DPFVS---KASKLFRFDFL-SPFLLSVVIFPFLTQLYEMLNISIFPR-------DSLNFFTKFVKRTKENH-LESNE--------KQRVNFLQMMLKS-Q-NF----------------------------------KDTESHK----------ALSDVEILAQSIFFIVAGYETTSSTLCFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMME-MEYLD-------------------------MVVNETLRLYPVTNRI-ERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE-PDEFRPERFSKKNKE--NIDPYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSFYTCKETQIPLRLGSQVILQPAKPIILKVVSRDET--------------------------------IRGA---- [503] 'gi|1903317|emb|CAB07513.1| cytochrome P450 [Sus scrofa] >gi|47523900|ref|NP 999588.1| cytochrome P450 3A29 [Sus scrofa] >gi|592' --------------------------------------------------------------------MDLIP----------------GFSTETWV------LLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYFGNILGYRKGV-DHFDKKC---FQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVFTNRRSF---G-PLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQ---------------------------DPFVE---NSKKLLKFSFF-DPFLLSLIFFPFLTPIFEVLNITLFPK-------SSVNFFTKSVKRMKESR-LTDQQ--------KRRVDLLQLMINS-Q-NS----------------------------------KEMDPHK----------SLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPTYDALAQ-MEYLD-------------------------MVVNETLRLYPIAARL-ERACKKDVEIHGVFVPKGTVVVVPVFVLHRDPDLWPE-PEEFRPERFSKKHKD--TINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGT--------------------------------VSGA---- [503] 'gi|30353835|gb|AAH52130.1| Hypothetical protein LOC324340 [Danio rerio] >gi|47086691|ref|NP 997838.1| hypothetical protein LOC3' --------------------------------------------------------------------MFDLS----------------SLSV-TWT------LVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALSYSKGI-CNFDIEC---SKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNP-D-LVGPFADGITLVKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKK-DPNLPLKIKDVVAPYSLDVVASSSFSVDFDSINNPD---------------------------DPFVT---SIKSFFNINPL-SPLFLLLAFCPSAANLLAKMGISVFSR-------STTDFYYKALRKIKDEH---NES--------NGRVDFLKLMIQN-Q-IPDDQVKDT---------------------------ASEQPVK----------GLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIPITYDALMR-MDYLE-------------------------MAIHESMRVFPAGPRL-ERVCKKTVEINGITIPKNTLVGIPLYVLSRDPDLWES-PNEFKPERFSPESKT--EINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLNF--FFQPKVPITLKLIPRSHK--------------------------------EKQ----- [505] 'gi|16033755|gb|AAL13316.1| cytochrome P450 3A [Sus scrofa]' --------------------------------------------------------------------MDLIP----------------GFSTETWV------LLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYFGNILGYRKGV-DHFDKKC---FQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVFTNRRSF---G-PLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQ---------------------------DPFVE---NSKKLLKFSFF-DPFLLSLIFFPFLTPIFEVLNITLFPK-------SSVNFFTKSVKRMKESR-LTDQQ--------KRRVDLLQLMINS-Q-NS----------------------------------KEMDPHK----------SLSNEELVGPGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPTYDALAQ-MEYLD-------------------------MVVNETLRLYPIAARL-ERACKKDVEIHGVFVPKGTVVVVPVFVLHRDPDLWPE-PEEFRPERFSKKNKD--TINPYTYLPFGTGPRNCIGMRFALMNMKLALVKVLQNFSFKPCKETQIPLKLTTQGLTPTEKPVVLKILPRDGP--------------------------------LSGA---- [503] 'gi|45826362|gb|AAS77822.1| cytochrome P450 3C1 [Danio rerio]' --------------------------------------------------------------------MFDLS----------------SLSV-TWT------LVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALSYSKGI-CNFDIEC---SKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNP-D-LVGPFADGITLVKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFMENMEKK-DPNLPLKIKDVVAPYSLDVVASSSFSVDFDSINNPD---------------------------DPFVT---SIKSFFNINPL-SPLFLLLAFCPSAANLLAKMGISVFSR-------STTDFYYKALRKIKDEH---NES--------NGRVDFLKLMIQN-Q-IPDDQVKDT---------------------------ASEQPVK----------GLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMR-MDYLE-------------------------MAIHESMRVFPAGPRL-ERVCKKTVEINGITIPKNTLVGIPLYVLSRDPDLWES-PNEFKPERFSPESKT--EINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLNF--FFQPKVPITLKLIPRSHK--------------------------------EKQ----- [505] 'gi|50755531|ref|XP 414782.1| PREDICTED: similar to MGC68821 protein [Gallus gallus]' --------------------------------------------------------------------MGLLP----------------DLPPITWL------LLAAFLGLLVLYGIWPYQTFKKLGIPGPRPLPFLGTFLRYRQGL-LNFDQMC---FEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTFTNRRVF---G-LSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNIEKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPS---------------------------DPFVT---NIRKFLKFSFL-NPLLIFIVLFPFMIPVLEKMNVTLLPT-------KVMDFFDAVFMKMKKER-EEGYH--------VDRVDFLQLMIDS-Q-SSQDSSKSA---------------------------REKDSYK----------SLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDVQKRLQDEIDANLPNKAAPTYNVVMQ-MEYLD-------------------------MVVNESLRLHPPGGRI-ERICKKTVEFNGVTIPKDMVVMIPAYVLHRDPAYWPK-PEEFRPERFSKENGE--NIDPYTFLPFGAGPRNCIGMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHS--------------------------------DPQN---- [510] 'gi|3879660|emb|CAA88604.1| Hypothetical protein T10B9.2 [Caenorhabditis elegans] >gi|17536177|ref|NP 496112.1| CYtochrome P450' -------------------------------------------------------------------------------------------MSLSIL------IAGASFIGLLTYYIWIWSFWIRKGVKGPRGFPFFGVIHEFQDYE-NPGLLKLGEWTKEYGPIYGITEGVEKTLIVSNPEFVHEVFVKQ-FDNFYGRKTNPIQGDPNKNKRAHLVSAQGHRWKRLRTLSSPTFSNKNLRKIMSTVEETVVELMRHLDDASAKGKAVDLLDYYQEFTLDIIGRIAMGQTESLMFR-----------------------------NPMLP---KVKGIFKDGR--KLPFLVSGIFPIAGTMFREF-FMRFPSI--QPAFDIMSTVEKALNKRLEQR-AADEKAGIEPS--GEPQDFIDLFLDA-R-ANVDFFEEESALGFAKT-------------------EIAKVDK----------QLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLARHPEIQKKLQEEVDRECPN-PEVTFDQISK-LKYME-------------------------CVVKEALRMYPLASIVHNRKCMKETNVLGVQIEKGTNVQVDTWTLHYDPKVWGEDANEFRPERWESGDEL--FYAKGGYLPFGMGPRICIGMRLAMMEKKMLLTHILKKYTFETSTQTEIPLKLVGSATTAPRS-VMLKLTPRHSN---------------------------------------- [520] 'gi|68358148|ref|XP 686863.1| PREDICTED: similar to cytochrome P450, family 3, subfamily a, polypeptide 13 [Danio rerio]' --------------------------------------------------------------------MIDLS----------------SLSV-TWT------LVVLVITLLFIYGVWPHRFFIKLGIPGPRPWPFVGTLLSYAKGL-CNFDMEC---AKKYGKVWGIYDGRLPILMVTDLEVIKVVLVKECYSNFINRRKRTT-G-LAGPFSDGIIMVKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKK-DPEQPVKIKEVVAPYSLDVITSSSFSVDIDSINNPE---------------------------DPFVI---NVKKFIQFNMF-NPLLLLILLFPSLAIPLKKMGVTLFSK-------SAMDFFYSVLKKIKDDH--NKES--------EGRVDFLKLMLQN-Q-IPDDQIQDSD--------------------------TSEQPAK----------GLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMR-MDYLE-------------------------MAINESMRLLPTAPRL-ERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWES-PGEFRPERFSPENKS--EFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEINV--TFQPKVPITLKLIPRSCN--------------------------------KKQ----- [507] 'gi|31043863|emb|CAD91645.1| cytochrome P450 [Homo sapiens]' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------FYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF---G-PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ---------------------------DPFVE---NTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPR-------EVTNFLRKSVKRMKESR-LEDTQ--------KHRVDFLQLMIDS-Q-NS----------------------------------KETESHK----------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ-MEYLD-------------------------MVVNETLRLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKD--NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT--------------------------------VSGA---- [430] 'gi|3875921|emb|CAB04112.1| Hypothetical protein F14F7.2 [Caenorhabditis elegans] >gi|17553062|ref|NP 499704.1| CYtochrome P450' --------------------------------------------------------------------------------------------MIILL------FVVSSVVGIVSYYFWTWTYWRRCGIPGPQGYPFLGSALDMMDHE-NPPFLQLKKWTSQYGKVYGITEGLLRTLVISDTNLIHEVFVKQ-YDNFYGRNLNPIQGDPNREKRVTLFSAQGHRWKRLRTIANPTFSSNNLRKIQVTVEDSALELLRHIEQHTAGGKAIDVLEYFQEFTMDVIGRIAMGQPDSLMFK-----------------------------NPLLP---CARDVFGKPR--TALFLSGILFPWIGPMIRKV-VFYFTNVFNNPAAQIMYQTANAVEQRIKQR-MAEEKAGIDP---GEPQDFIDLFLDA-K-SD--DMELENNEDFTK--------------------AGVKVTR----------QLTKDEVVGQCFVFLIAGFDTTALSLSYSSFLLATHPKAQKKLQEEIDRECAD-PEVTFDQLSK-LKYME-------------------------CVIKETLRMYPLGALANSRRCMRSTKIGNYEIEKGVDILCDTWTLHYDKSIWGEDAEEFKPERWESGDEH--FYQKGGYIPFGLGPRQCIGMRLAYMEEKLLLSHILRKYTLEVCNKTQIPLKLIGSRTTQPES-VWLNLTPRDDN---------------------------------------- [517] 'gi|5921922|sp|O70537|CP3AV MESAU Cytochrome P450 3A31 (CYPIIIA31) (P450 SH3A-1) >gi|3088333|dbj|BAA25811.1| CYP3A31 [Mesocricet' --------------------------------------------------------------------MDLTS----------------VLSLETWV------LLAISLVLLYRLGTHKYDIFKKQGIPGPKPLPFLGNVLNYYKGI-WTFDIEC---HKKYGKIWGLFEGQRPLFTVTDTEMIKNVLVKECYSIFTNRRDF---G-PVGIMSKAVSISKDEEWKRIRALLSPTFTSGKLKEMFPIIEQYGDILVKFLRREAEKGNPVTTKEVFGAYSMDVITSTAFGVSVDSLNNPK---------------------------D-LLW---KGRKLLRFDFF-DPLFLSVVLFPFLIPIYEKLNVSMFPK-------DSISFFRKFVDKTKENR-LDYNQ--------KHRVDFLQLMMNS-H-DN-----------------------------------SKDSHK----------ALSDMEIIAQSIIFIFAGYDTTSSTLSFALYLLATHPDVQKKLQEEIDIALPNKARPSYDKVME-MEYLD-------------------------MVLNETLRLYPIGSRL-ERVCKQDVEMDGVFVPKGSIVMVPVFALHYDPQYWPE-PEKFRPERFSKENKG--SIDPYIFLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSLQPCKETQIPMKLSRKAMLQPEKPIILKVVPRDAI--------------------------------ITGA---- [501] 'gi|47207730|emb|CAF91666.1| unnamed protein product [Tetraodon nigroviridis]' --------------------------------------------------------------------MDLLP----------------DFSIETWT------LIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGV-HHFDQEC---YKKYGKVWSLFDGRQPLMCIMDTLMIKTILIKECYSNFTNRRDL---G-LNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKVKADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPS---------------------------DPFVA---NIKKMVKFNFM-NPLLILVVLFPFTQTIFDKMDVSLFPG-------HVLDFFYNFLRQIKSDR-SKEKK--------KSRVDFMQLMVNA-H-MTEDN-------------------------------EKDSSLK----------GLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNPDIQKKLQEEIDKTFPGKVRPNYDDLMQ-LEYLD-------------------------MVVNESMRLYPIANRL-ERMAKTSVEINGVTIPKGTVVAIPVYALHRDPALWPE-PEAFKPERFSKENSA--NIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPIKLKLKPRTSS---------------------------------------- [502] 'gi|37528849|gb|AAQ92352.1| cytochrome P450 CYP3A43.3 [Homo sapiens]' --------------------------------------------------------------------MDLIP----------------NFAMETWV------LVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGL-WNFDREC---NEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPL---G-PMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQ---------------------------DPFLK---NMKKLLKLDFL-DPFLLLISLFPFLTPVFEALNIGLFPK-------DVTHFLKNSIERMKESR-LKDKQ--------KHRVDFFQQMIDS-Q-NS----------------------------------KETKSHK----------ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANKAPVTYDALVQ-MEYLD-------------------------MVVNETLRLFPVVSRV-TRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTE-PEKFCPERFSKKNKD--SIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGI--------------------------------TSGP---- [503] 'gi|3879659|emb|CAA88603.1| Hypothetical protein T10B9.1 [Caenorhabditis elegans] >gi|17536175|ref|NP 496111.1| CYtochrome P450' -------------------------------------------------------------------------------------------MSLSLL------IAGALFIGFLTYYIWIWSFWIRKGVKGPRGFPFFGVILKFHDYE-NPGLLKLGEWTKKYGSIYGITEGVEKTLVVSNPEFVHEVFVKQ-FDNFYGRKTNPIQGDPNKNKRAHLVLAQGHRWKRLRTLASPTFSNKSLRKIMSTVEETVVELMRHLDEASAKGKAVDLLDYYQEFTLDIIGRIAMGQTESLMFR-----------------------------NPMLP---KVKEIFKKGG--KMPFLIAGVFPIAGTLMRQL-FMKFPKF--SPAFGIMNTMEKALNKRLEQR-AADKKAGIEPS--GEPQDFIDLFLDA-R-ANVDFIEEESTLGFAKS-------------------EVLKVDK----------HLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEEVDRECPD-PEVTFDQISK-LKYME-------------------------CVVKEALRMYPLASLVHNRKCMKKTNVLGVEIDEGTNVQVDTWTLHYDPKVWGDDASEFKPERWETGDEL--FYAKGGYLPFGMGPRICIGMRLAMMEEKLLLTHILKKYTFDTSTETEIPLKLVGSATIAPRN-VMLKLTPRHSN---------------------------------------- [520] 'gi|14714763|gb|AAH10528.1| Cytochrome P450, family 3, subfamily a, polypeptide 11 [Mus musculus] >gi|74143649|dbj|BAE28873.1| u' --------------------------------------------------------------------MDLVS----------------ALSLETWV------LLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGL-WKFDMEC---YKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF---G-PVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPE---------------------------DPFVE---KAKKLLRFDFF-DPLLFSVVLFPFLTPVYEMLNICMFPK-------DSIEFFKKFVDRMKESR-LDSKQ--------KHRVDFLQLMMNS-HNNS----------------------------------KDKVSHK----------ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVME-MEYLD-------------------------MVLNETLRLYPIANRL-ERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSE-PEEFQPERFSKENKG--SIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPRDAV--------------------------------ITGA---- [504] ; END; BEGIN CODONS; CODESET * UNTITLED = Universal: all ; END; BEGIN ASSUMPTIONS; OPTIONS DEFTYPE=unord PolyTcount=MINSTEPS ; EXSET * UNTITLED = 1-246 262-265 297-325 327 331-333 344-345 347-359 366 373-379 397-399 403-410 424 426-463 467 470-479 533 544 550-574 577-579 591 614 629 645-646 699-760; END; BEGIN MacClade; Version 4.0 87; LastModified -1064180426; FileSettings editor '0' '0' '1' '1'; Singles 100; Editor 00011001111111100100010010 '1' '8' Geneva '9' '490' '1' all; EditorPosition '44' '39' '915' '1209'; TreeWindowPosition '46' '6' '959' '1230'; ListWindow Characters closed Geneva '9' '50' '10' '273' '359' 000; ListWindow Taxa closed Geneva '9' '50' '10' '276' '490' 100000000; ListWindow Trees closed Geneva '9' '50' '10' '276' '490' ; ListWindow TypeSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow WtSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow ExSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow CharSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow TaxSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow CharPartitions closed Geneva '9' '50' '10' '276' '490' ; ListWindow CharPartNames closed Geneva '9' '50' '10' '276' '490' ; ListWindow WtSets closed Geneva 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