#NEXUS 
[MacClade 4.08 registered to Tomoaki Nishiyama, National Institute for Basic Biology]


BEGIN DATA;
	DIMENSIONS  NTAX=86 NCHAR=724;
	FORMAT DATATYPE=PROTEIN  SYMBOLS = " 1 2 3 4"  MISSING=? GAP=- ;
MATRIX
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'gi|15219522|ref|NP 177510.1| CDKD1;1; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k'    ------------------M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQPKKVADRYLKREVLGQGTYGVVF--------KATD-TKNGETVAIKKI-----R----LGKE-------KEGVNVTALREIKLLKEL-KHPHIIELI-DAFP--HK-EN-LHIVFEFM-ETDLEAVIRDRNLY--LSPGDVKSYLQMILKGLEYCHGKWVLHRDMKPNNLLIGPN-GQLKLADFGLARIFGSPG------RKFTHQVFARWYRAPELLFGAKQYDGAVDVWAAGCIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPK-ADQWPDMICLPDYVE--YQFVPAPS------LRSLLPTVSEDALDLLSKMFTYDPKSRISIQQALKHRYFTSAP-------SPTDPLKLPRPVSKQDAKSSDSK-----LEAIKVLSPAH---------------------KFRRVMPDRGK---SGNGFKDQSVDVMR-QA---------SHDGQAPMSLDF-TILAERPPNRPTITSADRSHLKRK------LDLEFL-------   [398]
'gi|15220917|ref|NP 173244.1| CDKD1;3; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQPKKVADRYLKQEVLGQGTYGVVF--------KATD-TKTEQTVAIKKI-----R----LGKQ-------REGVNITALREIKMLKEL-KHPHIILLI-DAFP--HK-EN-LHLVFEFM-ETDLEAVIRDSNIF--LSPADIKSYLLMTFKGLAYCHDKWVLHRDMKPNNLLIGVD-GQLKLADFGLARIFGSPN------RKFTHQVFARWYRAPELLFGAKQYGAAVDVWAVACIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPK-ADQWPDLTKLPDYVE--YQFVPAPS------LRSLFPAVSDDALDLLSKMFTYDPKARISIKQALEHRYFTSAP-------APTDPAKLPKPVPKQDGKSSYGK-----HEAITVQSPPR---------------------KLRRVMPERGR------------VDSLKSHV---------DKDQQAPMSLDF-TILAERPPNRPTITSADRSHLKRK------LDLEFQ-------   [391]
'gi|15419985|gb|AAK97227.1| CDK-activating kinase [Medicago sativa subsp. x varia]'                                    ------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TELDPSKKVADRYLKREVLGEGTYGVVY--------KAID-TQTGQTVAIKKI-----R----IGKQ-------KEGVNFTALREIKLLKEL-KDPNIIELI-DCFP--HK-GN-LHLVFEFM-ETDLEAVIRDRNIF--LAPGDIKSYLQMTLKGLAHCHKKWILHRDMKPNNLLIGPN-GQLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLFGTKQYGPGVDVWAAACIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPS-PSQWPDMVYLPDYVE--YQFVPAPP------LRSLFPMATDDALDLLSKMFTYDPKDRISVQQALEHRYFTCPP-------QPTDPVKLPRPAPKKEIKPSDLNP----PEGPTVLSPPR---------------------KTRRVMPGRDG--LEGNSLQGDRVDDNHGNLKQTGG-DNTGKNEPAPMSLDF-SVFGLKPPNRPTINSADRSHLKRK------LDLEFQ-------   [412]
'gi|20194|emb|CAA41172.1| cdc2+/CDC28-related protein kinase [Oryza sativa (japonica cultivar-group)] >gi|266410|sp|P29620|KC47'     ------------------M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASGDGGDDAGVKRVADRYLKREVLGEGTYGVVF--------KAVD-TKTGNTVAIKKI-----R----LGKY-------KEGVNFTALREIKLLKEL-KDSNIIELI-DAFP--YK-GN-LHLVFEFM-ETDLEAVIRDRNIV--LSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGAD-GQLKLADFGLARIFGSPE------RNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPK-SSQWPDMVYLPDYVE--YQFVSAPP------LRSLFPMASDDALDLLSRMFTYDPKARITAQQALEHRYFLSVP-------APTKPSQLPRPPPKGDSGNNKIPDLNL-QDGPVVLSPPR---------------------KLRRVTAHE-G--MEVHMHRADRTEEHPSGARHMD--DMSSQSSRIPMSVDVGAIFGTRPAPRPTLNSADKSRLKRK------LDMDPEFGYTE--   [424]
lcl|Smo_CDKD1_2_1_unnamed_protein_product                                    AVASALQCVTLDGLKMLEL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNGIGAKRYVKGISLGEGTYGVVF--------KALD-TQTNRTVAVKKI-----R----LGKY-------KEGVHVTALREIKLLKEL-RDPNIIELI-DVYP--HK-RN-LHLVFEFM-ESDLEAVIRDRNIL--LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSD-GQLKLGDFGLARIFGSPD------RKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFQAFGTPR-ETQWPDMTSLPDYVE--FQFTPAPA------LRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYFSTDP-------APTKAHLLLRPASKAEGMRPPPELAS--PKEPVVLSPPA---------------------KARRISLFP-G--VAGAEHIHHSKESKDGSSAATVG-ETPSDHSGMAMSVDA------RMTIRPTLSSTDRSYLKRK------LDMDVHFEDERHV   [429]
'gi|15219730|ref|NP 176847.1| CDKD1;2; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine k'    ------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SK-SGDNQPVDRYLRRQILGEGTYGVVY--------KATD-TKTGKTVAVKKI-----R----LGNQ-------KEGVNFTALREIKLLKEL-NHPHIVELI-DAFP--HD-GS-LHLVFEYM-QTDLEAVIRDRNIF--LSPGDIKSYMLMTLKGLAYCHKKWVLHRDMKPNNLLIGEN-GLLKLADFGLARLFGSPN------RRFTHQVFATWYRAPELLFGSRQYGAGVDVWAAGCIFAELLLRRPFLPGSTEIDQLGKIFQAFGTPV-PSQWSDMIYLPDYME--FSYTPAPP------LRTIFPMASDDALDLLAKMFIYDPRQRITIQQALDHRYFSSSP-------SPTEPGKLQIPASKGDALEPKASEQNQHGNSPAVLSPPG---------------------KMRRVMGPE-G------------------------------------------------------------------------------F---T--   [348]
lcl|Smo_CDKD1_1_1_unnamed_protein_product                                    -------CVTLDGLKCLEL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNGIGAKRYVTGISLGEGTYGVVF--------KALD-TQTNRTVAVKKI-----R----LGKY-------KEGVHVTALREIKLLKEL-RDPNIIELI-DVYP--HK-RN-LHLVFEFM-ESDLEAVIRDRNIL--LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSD-GQLKLGDFGLARIFGSPD------RKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFQAFGTPR-ETQWPDMTSLPDYVE--FQFTPAPA------LRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYFSTDP-------APTKAHLLLRPASKAEGMRPPPELAS--PKEPVVLSPPA---------------------KARRISLFP-G--VAGAEHIHHSKESKDGSSAATVG-ETPSDHSGMAMSVDA------RMTIRPTLS?----------------------------   [400]
lcl|Ppa_CDKD1_19_1_unnamed_protein_product                                    -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNRTVAIKKI-----R----LGKL-------KEGVNVTALREIKLLKEL-QDPNIIELI-DVYP--HK-SN-LHLVFEYM-ESDLEAVIRDRNIF--LSPADYKAYMQMILKGLAVCHKKWVLHRDLKPNNLLLGSN-GQLKLADFGLARIFGSPD------RKFTHQVFARWYRAPELLFGSKQYGPGVDVWAAACIFAELILRRPFLQGSSDIDQLGKIFAAFGTPG-KAQWPDVTSLPDYVE--YQHSPPQS------FRSLFPQASEDCIDLLQRMFTYDPKRRITAQQALEHRYFRTEP-------APTPCHMLRRPS-KPEAQPKPIELLS--PAGHIVFSPPT---------------------KTRRLQLF-------GGDIKTAGEANRDGQAKQQLELGTPIDAITIPMSIDP------KTNLRPTLNRTLNRSLQVKPSGYANATLSPHSSFTSGF   [382]
lcl|Ppa_CDKD1_10_1_unnamed_protein_product                                    ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFRAPVDDVVS--------GYMNIGETNRTVAIKKI-----R----LGKL-------KEGVNVTALREIKLLKEL-QDPNIIELM-DVYP--HK-SN-LHLVFEYM-ESDLEAVIRDRNIF--LSSADCKAYMQMILKGLAVCHKKWVLHRDLKPNNLLLGSN-GQLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLFGSKQYGPGVDVWAAACIFAELILRRPFLQGSSDIDQLGKIFGVFGTPG-EAQWPDVTSLPDYVE--YQYSPPQS------FRSLFPQASEDCIDLLQRMFTYDPKQRITAQLALEHRYFRTEP-------APTPCYMLRRPV-KPEVHPKPIELLS--PAGHIVFSPPT---------------------KTRRLQLF-------GGDIKTAGEASRDTHAKLQPELGTPIDAITIPMSIDP------KTNLRPTLN?----------------------------   [372]
lcl|Ppa_CDKD1_1_1_unnamed_protein_product                                    ------------------M-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDVTGVNRYDKGVTIGSGTFGIVF--------KAID-KLTNRTVAVKMI-----R----TGKY-------KEGVNVTALREIKLLKEL-YDPNVIELV-DVYQ--HK-RN-LYLVFEYM-ESDLEAVIYDRNTF--LSPADYKSYIYMTLKGLAFCHKKWILHRDMKPNNLLLGSD-GQLKIADFGLARIFGSPD------RRFTHEVFARWYRAPELLFGSKMYGPGVDVWAVACIFAELILRRPLFQGTSDIDQLGKIFATFGTPR-ESQWPDMTSLPNYVE--YSYSPPQP------FRTLFPQASEDCLDLLQRMFTYDPRQRISAQQALEHRQLLLLHYALHYSSGILEQSQQQRP-------------------------------------------------HICFVGQFGNK-------------------------------------------------------------------------------------   [323]
'gi|55977996|gb|AAV68598.1| CDK activating kinase/cell cycle dependent kinase D [Ostreococcus tauri]'                                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERYERGRTLGEGTYGVVH--------EARV-KETNEVVAIKKI-----R----LGKL-------KEGVNFTAIREIKLLQEI-KHEHVIELV-DVFA--HK-KN-LNLVFEYC-GGDLEMVIKDKATP--LSAGEVKSYARMTLRAVAHCHENWVLHRDLKPNNLLIAPN-GCLKLADFGLARIFGSPD------RRFTHQVFARWYRAPELLLGSKTYGPGVDVWAVGCILAELMLRKPFFAGSSDIDQLGKVYAALGTPT-ETNWPGVSALPDFIE--FIYVPPPN------LHDTFPNETNESLDLLKRMLEYDPNKRITAAQALEHPYFHTKP-------APIPFEELPKRFATKNFTQHASGGTSPSREAKTG--------------------------EKRRLEDADEAPDSTDPNFRPKPRRRRTGEGVAAVAKGAFGT---------------------PPFARRSRGDELKT------RRFSPTPLAGN--   [389]
'gi|68361250|ref|XP 691759.1| PREDICTED: similar to cdc2-related protein p40 MO15 [Danio rerio]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KTTNTIVAIKKI-----K----VGHRTEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDYM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHNHWILHRDLKPNNLLLDEN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPT-DEIWPGMSSLPDYVS--FKPFPGTP------LEHIFSAAGDDLLELLRGLFTYNPCSRTTAMQALKMKYFSNRP-------GPTPGPQLPRPNSSTEA-LKEKENLLI---GI----------------------------KRKR-DSIEQG--MSSPSSDNEGQHGHAESDARIAAVPQMSHANMIHTNNPR-----YHLHPITSNSQSPSSVFHSK------QQL----------   [399]
'gi|33304107|gb|AAQ02561.1| cyclin-dependent kinase 7 [synthetic construct]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP-------GPTPGCQLPRPNCPVET-LKEQSNPAL---AI----------------------------KRKRTEALEQG-------------------------------------------------------------GLPKK------LIFL---------   [347]
'gi|13529020|gb|AAH05298.1| Cyclin-dependent kinase 7 [Homo sapiens]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHRHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP-------GPTPGCQLPRPNCPVET-LKEQSNPAL---AI----------------------------KRKRTEALEQG-------------------------------------------------------------GLPKK------LIF----------   [346]
'gi|12654057|gb|AAH00834.1| Cyclin-dependent kinase 7 [Homo sapiens] >gi|4502743|ref|NP 001790.1| cyclin-dependent kinase 7 [Hom'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP-------GPTPGCQLPRPNCPVET-LKEQSNPAL---AI----------------------------KRKRTEALEQG-------------------------------------------------------------GLPKK------LIF----------   [346]
'gi|83523756|ref|NP 998126.2| hypothetical protein LOC405897 [Danio rerio] >gi|83033260|gb|ABB97084.1| Cdk7 [Danio rerio]'           ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KTTNTIVAIKKI-----K----VGHRTEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDYM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHNHWILHRDLKPNNLLLDEN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPT-DEIWPGMSSLPDYVS--FKPFPGTP------LEHIFSAAGDDLLELLRGLFTYNPCSRTTAMQALKMKYFSNRP-------GPTPGPQLPRPNSSTEA-LKEKENLLI---GI----------------------------KRKR-DSIEQG-------------------------------------------------------------TLKKK------LVF----------   [345]
'gi|76646215|ref|XP 869371.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPS------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDFVT--FKSFPGIP------LQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYFSNRP-------GPTPGCQLPRPNCPAEA-LKEQSNPAM---AT----------------------------KRKRTEALEQG-------------------------------------------------------------GLPKK------LIF----------   [346]
'gi|2125816|emb|CAA73587.1| serine/threonine protein kinase [Homo sapiens]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--CKSFPGIP------LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP-------GPTPGCQLPRPNCPVET-LKEQANPAL---AI----------------------------KRKRTEALEQG-------------------------------------------------------------GLPKK------LIF----------   [346]
'gi|45768758|gb|AAH68160.1| Cdk7 protein [Mus musculus] >gi|74217064|dbj|BAE26631.1| unnamed protein product [Mus musculus] >gi|'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGVP------LQHIFIAAGDDLLELIQGLFLFNPCTRTTASQALKTKYFSNRP-------GPTPGCQLPRPNCPVEA-LKEPANPTV---AT----------------------------KRKRAEALEQG-------------------------------------------------------------ILPKK------LIF----------   [346]
'gi|34853514|ref|XP 215467.2| PREDICTED: cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) [Rattus norve'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLAFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LQHIFIAAGDDLLELIQGLFLFNPCTRITASQALRTKYFSNRP-------GPTPGCQLPRPNCPVEA-LKEQSNPAM---AT----------------------------KRKRAEALEQG-------------------------------------------------------------ILPKK------LIF----------   [346]
'gi|62857669|ref|NP 001017219.1| cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) [Xenopus tropic'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGIMARGVDVRSRSKQYEKLEFLGEGQFATVY--------KARD-KNTDRIVAIKKI-----K----LGHRAEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPGMSSLPDYVA--FKSFPGTP------LHHIFIAAGDDLLELLQGLFTFNPCARCTASQALRKRYFSNRP-------APTPGSLLPRPNCSVEA-LKEQQNLNL---GI----------------------------KRKRTEGMDQK-------------------------------------------------------------DIAKK------LNF----------   [352]
'gi|68566250|sp|P51952|CDK7 RAT Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor c'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANRNEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------WAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LQHIFIAAGDDLLELIQGLFLFNPCTRITASQALRTKYFSNRP-------GPTPGCQLPRPNCPVEA-LKEQSNPAM---AT----------------------------KRKRAEALEQ--------------------------------------------------------------------------------------   [329]
'gi|619509|emb|CAA58562.1| CdK-activating kinase Cdk7 [Rattus norvegicus] >gi|1083627|pir||S51085 CdK-activating kinase Cdk7 - r'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANRNEKLDFLGEGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------WAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGIP------LQHIFIAAGDDLLELIQGLFLFNPCTRITASQALRTKYFSNRP-------GPTPGCQLPRPNCPVEA-LKEQ--------------------------------------------------------------------------------------------------------------------------------------   [312]
'gi|47226698|emb|CAG07857.1| unnamed protein product [Tetraodon nigroviridis]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDVKSRSKRYEKLDFLGEGQFATVY--------KARD-KTTDTIVAIKKI-----K----VRHITEA----KDGINRTALREIKLLQEL-HHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPANIKAYILMTLQGLEYMHQHWVLHRDLKPNNLLLDGN-GVLKLADFGLAKAFGSPN------RVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRLPFLAGDSDLDQLTKIFEALGTPT-EESWPGLTSLPDYVS--FKIFPGTP------LEHIFSAAGDDLLELLQGFFTFNPLMRSTATQALKMRYFSNRP-------GPTPGPQLPRPNCSVEA-LREKETVGL---------------------------------KRKI--------------------------------------------------------------------------------------------   [329]
'gi|64960|emb|CAA37915.1| unnamed protein product [Xenopus laevis] >gi|125413|sp|P20911|CDK7 XENLA Cell division protein kinase'     ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGIAARGVDVRSRAKQYEKLDFLGEGQFATVY--------KARD-KNTDRIVAIKKI-----K----LGHRAEA----NDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDTSLV--LTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPGMSSLPDYVA--FKSFPGTP------LHLIFIAAGDDLLELLQGLFTFNPCARCTASQALRKRYFSNRP-------APTPGNLLPRPNCSIEA-LKEQQNLNL---GI----------------------------KRKRTEGMDQK-------------------------------------------------------------DIAKK------LSF----------   [352]
'gi|395048|emb|CAA52242.1| protein kinase [Mus musculus] >gi|33859522|ref|NP 034004.1| cyclin-dependent kinase 7 (homolog of Xen'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKHNEKLDFLGRGQFATVY--------KARD-KNTNQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLELIIKHNSLV--LTPSHIKAYMLMTLQGLEYLHHNWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDYVT--FKSFPGVP------LQHIFIAAGDDLLELIQGLFLFNPCTRTTASQALKTKYFSNRP-------GPTPGCQLPRPNCPVEA-LKEPANPTV---AT----------------------------KRKRAEALEQG-------------------------------------------------------------ILPKK------LIF----------   [346]
'gi|73949665|ref|XP 850424.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVDVKSRAKRYEKLDFLGEGQKSSVFSPDCPGLQRPET-KNTHQIVAIKKI-----K----LGHRSEA----KDGINRTALREIKLLQEL-SHPNIIGLL-DAFG--HK-SN-ISLVFDFM-ETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT-EEQWPDMCSLPDFVT--FKSFPGIP------LQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYFSNRP-------GPTPGCQLPRPNCPLET-LKEQSNPAV---AT----------------------------KRKRTQALEQG-------------------------------------------------------------GLPKK------LIF----------   [354]
lcl|4174_Cre_unnamed_protein_product                                    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAENYVRGALLGQGTFAAVY--------KGSD-KRTGKPVALKEIFPDDKG----GAEG-------KKGLDPTALREIKLLREL-QHEHIIRLM-DAYP--KK-KS-VVLVLEYM-HSDLEAVIKDGNLV--LAAADVKSYMQQLLTALETCHSRWVLHRDIKPNNCLIAPD-GKLKLADFGLSRVYGSPD------GRLTHKVFAPWYRAPELFFGAKQYTSAVDVWAAGCIMGELLLRRPLFDGMSDIEVLAKVFAVCGTPGVDGNWPAARDLPYFLQ--FTETKPLP------LRQVFPAASGDALDLLGRMLCLDPQRRITAAEALAHPYFANNP-------PPTPPALLPRPLKREDAPLASGVAPGAA--------------------------------KGRERMSPSASPRPSKAPRRTGPSGTATPR------------------------------------------------------------------   [353]
'gi|21295523|gb|EAA07668.1| ENSANGP00000002848 [Anopheles gambiae str. PEST] >gi|31206629|ref|XP 312281.1| ENSANGP00000002848 [A'    ------------------L-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMEILNRLNRYEKIDFLGEGQFATVY--------KARD-AETNEIVAVKKI-----K----IGNREEA----ADGINRTALREIKLLHEL-QHENIIGLL-DVFG--HK-SN-VSLVFDFM-DTDLEIIIKDPKII--LTPANIKSYMIQTLRGLEYLHQHWILHRDLKPNNLLISGT-GVLKIGDFGLAKFFGSPN------RINTNQVVTRWYRCPELLFGARQYGIGVDIWAVGCILAELLLRVPFLPGESDLDQLTRIFQVLGTPN-ETNWPDVKSLPDYVQ--YKFYPPIP------LRDIFTAASDDLIELANKMLALYPLHRCSCTEALKMAYFSNKP-------APTVGPRLPMPASYNAANSKPEEKPSL---------------------------------KRKLLDSIDGG-------------------------------------------------------------TVPKR------LQF----------   [345]
'gi|1098032|prf||2115201A Mo15 kinase-related protein'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYMIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-KHDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWPGVTCLPNYIK--FTDHPATP------FKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGV-------KHTNPADLPVPFAKKASLLQQRQVLAQV--------------------------------QQQLLQKQQQQQQQQQQQIQSQPEPIQGDNVEQTQQAQQGKK------------------------------------------------------   [362]
'gi|7579907|gb|AAB35208.2| Mo15 [Dictyostelium discoideum] >gi|1705721|sp|P54685|CDK7 DICDI Cell division protein kinase 7 (CDK-'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYNIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-KHDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWPGVTCLPNYIK--FTDHPATP------FKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGV-------KHTNPADLPVPFAKKASLLQQRQVLAQV--------------------------------QQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQVKK------------------------------------------------------   [362]
'gi|66809013|ref|XP 638229.1| CDC2 family protein kinase [Dictyostelium discoideum] >gi|60466494|gb|EAL64546.1| Mo15 [Dictyostel'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKYNIEALIGEGTYGVVS--------RATV-KATGQIVAIKKI-----RKILIQNQT-------DDGINFSAIREIKILQEL-KHDNVVNLL-DIFA--HK-SN-VYLVFELM-QWDLQEVIEDKSII--LKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSIN-GDLKLADFGLARQYGSPN------KVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPN-ESNWPGVTCLPNYIK--FTDHPATP------FKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGV-------KHTNPADLPVPFAKKASLLQQRQVLAQV--------------------------------QQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV--------------------------------------------------------   [360]
'gi|71021637|ref|XP 761049.1| hypothetical protein UM04902.1 [Ustilago maydis 521] >gi|46100613|gb|EAK85846.1| hypothetical prot'    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METAAAQNLLIANSYAKVEKVGEGTYASVF--------LARS-INTGQKVAIKKI-----K----IVSN-------ENGMDVTAIREVKFLKEL-NHPNVIKLV-DVFSSGSRSPS-LNLVLEFL-DTNLEALIKDRTLI--FTQADIKSWMAMLCRGLEYCHRYWVLHRDLKPNNLLISPQ-GELKIADFGLAREHGDPG------ARMTHQVVTRWYRPPELLLGSRAYSSAVDMWSVGCIFAELMLRVPYLPGESDADQLITIFKALGTPT-DKDWPGHKSLPEYTA--FEQYPKSN------LADLFLAASPEALDFLQKMLLFDPLKRLSANQALHHAYFKQGP-------PPTPFKQLPRHPTKALDSGDPAAHPLLSDS------------------------------KEKNEVREKQQNQAHGNGNVNGNSRKRPFDAKEIEE----------------------------------RRRLARK------LAFA---------   [379]
'gi|57230869|gb|AAW47178.1| cyclin-dependent protein kinase, putative [Cryptococcus neoformans var. neoformans JEC21] >gi|582625'    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLASQENSQRANRWDKGIKIGEGTFANVY--------KGTE-KATGRKVAIKKI-----K----VGEM-------KHGLDMTALREVKFLQEL-KHPNIISLL-DVFS--VK-QN-INLVLEFL-DTDLEAVIRDKALI--FQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAAN-GELKIADFGLAREFGDAG------NKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILRVPFLAGETDIDQLKKTFHAMGTPT-EQDWPGYTKLPDYHE--VGSFPKNP------WWNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTSYP-------PPTPPIALPKPLAELRPRELAPDETQGKPLLTSG--------------------------AGQSLKRKAESPRTSQ--------------------------------------------------------SVPRK------LIFT---------   [358]
'gi|57230868|gb|AAW47177.1| cyclin-dependent protein kinase, putative [Cryptococcus neoformans var. neoformans JEC21] >gi|582625'    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKAQENSQRANRWDKGIKIGEGTFANVY--------KGTE-KATGRKVAIKKI-----K----VGEM-------KHGLDMTALREVKFLQEL-KHPNIISLL-DVFS--VK-QN-INLVLEFL-DTDLEAVIRDKALI--FQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAAN-GELKIADFGLAREFGDAG------NKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILRVPFLAGETDIDQLKKTFHAMGTPT-EQDWPGYTKLPDYHE--VGSFPKNP------WWNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTSYP-------PPTPPIALPKPLAELRPRELAPDETQGKPLLTSG--------------------------AGQSLKRKAESPRTSQ--------------------------------------------------------SVPRK------LIFT---------   [356]
'gi|54643727|gb|EAL32470.1| GA17354-PA [Drosophila pseudoobscura]'                                    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APHSSDKGDRYAKLSFLGEGQFAIVY--------KARD-TVTSQIVAVKKI-----K----RGSREDA----RDGINRTALREIKILQEL-QHENIIGLV-DVFG--QL-SN-VSLVFDFM-DTDLEVIIKDTKII--LTQANIKAYAIMTLRGLEYLHLHWILHRDLKPNNLLVNSD-GVLKIGDFGLAKTYGSPN------RIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFIPGDSDLDQLTRIFATLGTPS-EAEWPYLGKLHDYLQ--FRHFTGTP------LENIFTAADNDLIHLMRRLFAMNPLRRVSCREALSMPYFGNKP-------APTVGPKLPLPSAIVAANAKADEKPGQ---AV----------------------------KRKLVETTVRG----------------------------------------------------------NSLPQKKR------LQF----------   [350]
'gi|66571170|gb|AAY51550.1| IP01401p [Drosophila melanogaster] >gi|17530793|ref|NP 511044.1| Cyclin-dependent kinase 7 CG3319-PA'    ------------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPNANDKTERYAKLSFLGEGQFATVY--------KARD-TVTNQIVAVKKI-----K----KGSREDA----RDGINRTALREIKILQEL-QHENIIGLV-DVFG--QL-SN-VSLVFDFM-DTDLEVIIKDNKII--LTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSD-GILKIGDFGLAKSFGSPN------RIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPT-EAEWPHLSKLHDYLQ--FRNFPGTP------LDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKP-------APTVGPKLPMPSAILAAKEGANPQTGDTKPAL----------------------------KRKLVETTVRG----------------------------------------------------------NGLAQKKR------LQF----------   [353]
'gi|68474238|ref|XP 718828.1| putative protein kinase [Candida albicans SC5314] >gi|68474409|ref|XP 718744.1| putative protein k'    ------------------MS----------------------------------------------------------------------------------------------------------------------------------------------TAAV-------------------------------------------ATKPSVTSKPATKQVSNYTKEKKVGEGTYAVVY--------LGKQ-ISTKRQIAIKEI-----K----TGLF-------KDGLDMSALREVKYLQEL-KHPNVIELV-DVFS--AT-NN-LNLVLEFL-PCDLEVLIKDKSIV--FKSADIKSWLLMTLRGIHHCHRNFILHRDLKPNNLLLAPD-GQLKIADFGLARALVNPN------EDLSSNVVTRWYRAPELLFGARHYTGAVDIWSIGIIFAELMLRIPYLPGKDDVDQLDVTFRAYGTPT-EQIWPNVSSLPMYNA--LHVYPPPS---RQELRNRFSAATEKALDLLISMTQLDPSRRCDSTLALLHDYFTESP-------RPTDPKKLPKKSSPEKRENEDEQNNGSKRRHV----------------------------------------------------------------------------------------------------------------------------   [343]
'gnl|CMER|CMN139C CDK-activating kinase'                                    ------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQPVERYEKQRVLGQGTYGVVY--------LAID-RCTAQPVALKKV-----R----LADY-------TAGLSMTAWRELRLLPELGGHPNVIALL-DVFS--TK-SSELYLVYEYC-ETDLEHLITERNLM--LSQGDIKSCLRQLLEGVAACHENWVLHRDLKPSNVLVTTD-GVLKLADFGLARVYAEPDLGTEGGRRMTHQVVTRWYRAPELLFGATAYGPAVDIWAVGCIFAELMRRVPFLPGQNDLDQLGKIAATLGAPT-PDQWPGVDALPAYLP--FKSVQRQP------LADLFRAAPPSAIDLLSRMLALNPNERISARDALEHAFFHTGA-------AESDPRELMVRWRKAQAHRRAAKTERHS--------------------------------------------------------------------------------------------------------------------------------   [328]
'gi|987976|emb|CAA62621.1| Cdk-activating kinase [Schizosaccharomyces pombe] >gi|3150140|emb|CAA19127.1| crk1 [Schizosaccharomyc'    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDIEKSDKWTYVKERKVGEGTYAVVF--------LGRQ-KETNRRVAIKKI-----K----VGQF-------KDGIDISALREIKFLRES-RHDNVIELV-DVFS--TK-SN-LNIILEFL-DSDLEMLIKDKFIV--FQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSD-GVLKLADFGLSRDFGTPS-------HMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRALGTPE-PEVIKSMQQLPNYVE--MKHIPPPN----GGMEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSALP-------KPTHPSLLPRKGGEEGIKHVSSDLQRQNNFPMRANIKFV---------------------------------------------------------------------------------------------------------------------   [335]
'gi|66547195|ref|XP 395800.2| PREDICTED: similar to ENSANGP00000002848 [Apis mellifera]'                                    ------------------M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISNTQIFCIIDI-----S----EYNTKNPDGKDRDGINRTALREIKLLQEL-KHDNVIGLL-DVFG--HK-SN-VSLVFDFM-DTDLEIIIKDNNIV--LTAANIKAYMIQTLQGLDYLHYNWILHRDLKPNNLLVNAE-GVLKIGDFGLAKFFGSPN------RINTHQVVTRWYRAPELLYGARLYGTGIDMWAVGCILAELLLRVPFLPGESDLDQLTRIFQTLGTPT-EETWPGMTELPDFIQ--FKPFPGTP------LKHIFTAAGDDLLDLIASLLNVNPLERCTCDQALQMPYFSNKP-------APTPGLRLPLPTSVKRQ---PEEKPSL---------------------------------KRKLLESMDGA-------------------------------------------------------------SLAKR------LQF----------   [316]
'gi|50309219|ref|XP 454616.1| unnamed protein product [Kluyveromyces lactis] >gi|49643751|emb|CAG99703.1| unnamed protein produc'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTLKSTVDDYTKEKKAGEGTYAVVY--------LGTK-KSTGRSIAVKEI-----K----TSQF-------KDGLDMSALREVKFLQEL-KHVNVIELV-DVFM--AN-DN-LNLVLEFL-PADLEIIIKDTSIM--FSPADIKSWILMTLRGVHHCHRNFILHRDLKPNNLLLAPD-GQLKIADFGLARLMASPQ------EILTSNVVTRWYRAPELLFGAKHYTSAVDIWSVGVIFAELMLRIPYLPGKDDVDQINVTFRALGTPT-DADWPEVSSFSNYNK--IQIYPPPS---REELRRRFIAATENALELISGMMIMNPKKRWDAVKCLQSQYFQELP-------EPTLPQDLPKLNK-----------------------------------------------------------------------------------------------------------------------------------------------   [310]
'gi|39595255|emb|CAE60292.1| Hypothetical protein CBG03876 [Caenorhabditis briggsae]'                                    ------------------M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKRYETIRHLGEGQFANVY--------MAKD-LETGEVVAIKKI-----K----LGSREEA----KDGINRTAIREIKLLKEI-HHDNIITLR-DVIG--HR-TS-IQLVFDFM-DTDLEHVVKDQSII--LSPSHIKNITMQMLLGMEFLHTHWILHRDLKPNNLLLNNM-GRVKVTDFGLARFFGSPN------RNYTHQVVTRWYRAPELLFGARSYGVGIDIWSIGCIIAELLLRNPIFPGDSDIDQLVKIFNVLGCPT-DESWPTMKAMNSYVN--IKPQSETP-----GLNFIFSAAPQDLIDLMTGMWVFDPVKRLTCTQSLQMEYFRAQP-------YCCLDEELPLPNKKPA--------------------------------------------KRTRRLEEDGS-------------------------------------------------------------HPARR------LIFD---------   [329]
'gi|29436789|gb|AAH49499.1| Cyclin-dependent kinase 2 [Danio rerio] >gi|50811836|ref|NP 998571.1| cyclin-dependent kinase 2 [Dan'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFQKVEKIGEGTYGVVY--------KAKN-KVTGETVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLR-DVIH--TE-NK-LYLVFEFL-HQDLKRFMDSTSVSG-ISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQ-GEIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-ESIWPGVTSMPDYKP-SFPKWARQD------LSKVVPPLDEDGRDLLGQMLTYDPNKRISAKNALVHRFFRDVT-------MPVPPLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|21166344|gb|AAK68887.2| Cyclin-dependent kinase family protein 7 [Caenorhabditis elegans] >gi|25145738|ref|NP 490952.2| Cycl'    ------------------M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRRYDTIKHLGEGQFANVY--------LAQD-LESGECVAIKKI-----K----LGSREEA----KDGINRTAIREIKLLKEI-HHDNIIGLR-DVIG--HR-TS-IQLVFDFM-DTDLEHVIKDKEII--LMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKM-GRVKLTDFGLARFFGSPN------RNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPT-PETWPNMTEMNSYVI--IKPQTEYM-----ALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYFRTQP-------FCCLDEELPLPKKQQPQ-------------------------------------------KRSRRLDDDGT-------------------------------------------------------------RPVRR------LNFD---------   [330]
'gi|51105850|gb|AAT97347.1| GDBD-TEV-Kin28-HA fusion protein [Yeast two-hybrid vector pMK498-TEV]'                                   ------------------MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSNYLFDDEDTPPNPKKEIELENLYFQGEFQ---------------------LTTMAMKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-QHPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWPEVSSFMTYNK--LQIYPPPS---RDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELP-------PPSDPSSIKIRNVMAIPGGGRIFYPYDVPDYAGYPYDVPDYAGSYPYDVPDYAAQCGRSS------------------------------------------------------------------------------------------------   [535]
'gi|51105852|gb|AAT97348.1| GDBD-TEV-CTDx3-Kin28-HA fusion protein [Yeast two-hybrid vector pMK500-TEV]'                             ------------------MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSNYLFDDEDTPPNPKKEIELENLYFQGEFQYSPTSPSYSPTSPSYSPTSPSLTTMAMKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-QHPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWPEVSSFMTYNK--LQIYPPPS---RDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELP-------PPSDPSSIKIRNVMAIPGGGRIFYPYDVPDYAGYPYDVPDYAGSYPYDVPDYAAQCGRSS------------------------------------------------------------------------------------------------   [556]
'gi|6320095|ref|NP 010175.1| Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcripti'    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVNMEYTKEKKVGEGTYAVVY--------LGCQ-HSTGRKIAIKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-QHPNVIELI-DIFM--AY-DN-LNLVLEFL-PTDLEVVIKDKSIL--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPD-GQIKVADFGLARAIPAPH------EILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPT-DRDWPEVSSFMTYNK--LQIYPPPS---RDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELP-------PPSDPSSIKIRN------------------------------------------------------------------------------------------------------------------------------------------------   [306]
'gi|72006599|ref|XP 783544.1| PREDICTED: similar to Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal tr'    ------------------M------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQRVQ--------RFATVY--------KALDLQHDGKIVAVKKI-----K----LGHRSEA----QDGINRTALREIKLLQEI-KHENVIGVIWDPFSANHI-HQ-IELVFFLI-CLLLQVIIKDSSVV--LTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDEN-GVLKIGDFGLAKFYGSPN------RIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFLPGESDLDQLSRIFQTMGTPS-EEEWPNMSALADYIE--FKKFPGTP------LRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYFYTKP-------APTPGHLLPRPGMVAAA-ANGKQQPKL---GS----------------------------KRKMADDIGTG----------------------------------------------------------QYSSVNKA------YSYSFEGKSAL--   [346]
'gi|251620|gb|AAB22550.1| cell division kinase; cyclin-dependent kinase; cdk2 [Carassius auratus] >gi|1168865|sp|P43450|CDK2 CAR'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFQKVEKIGEGTYGVVY--------KAKN-KVTGETVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLH-DVIH--TE-NK-LYLVFEFL-HQDLKRFMDSSTVTG-ISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQ-GEIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPD-ESIWPGVTSMPDYKP-SFPKWARQD------LSKVVPPLDEDGRDLLGQMLIYDPNKRISAKNALVHRFFRDVT-------MPVPPLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|47208706|emb|CAF90431.1| unnamed protein product [Tetraodon nigroviridis]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRH-KATGQVVAMKKI-----R----LESE-------EEGVPSTAIREVSLLQEL-KHPNVVRLL-EVLM--HD-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMEPMLVKSYLYQILEGILFCHCRRILHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPIDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKS-TFPKWKSGN------LS--VKNLDKDALDLLAKMLTYNPPKRISAREAMKHPYFDDLD-------------------------------------------------------------------------------------------------------------------------------------------------------------------   [289]
'gi|44982328|gb|AAS51637.1| ADL283Wp [Ashbya gossypii ATCC 10895] >gi|45187590|ref|NP 983813.1| ADL283Wp [Eremothecium gossypii]'    -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTAVNYTKEKKVGEGTYAVVY--------LGHR-QTDGRQIAIKEI-----K----TSQF-------KDGLDMSAIREVKYLQEI-RHANVIELV-DLFM--AQ-EN-LNLVLEFL-PADLEMLIKDSSLL--FTQADIKSWLLMTLRGVHHCHRSFILHRDLKPNNLLLAPD-GQLKIADFGLARTLAAPH------EFMTSNVVTRWYRAPELLFGARHYTAAVDLWSVGVIFAELMLRIPYLPGRDDVDQIDVTFRALGTPT-DKDWPEVSSFSAYNK--IQVYPPPS---RSELRSRFIAATENALDLMCGMLTMDPHKRWDTTRCLLSQYFVELP-------EATPPTELPKLNK-----------------------------------------------------------------------------------------------------------------------------------------------   [306]
'gi|11034748|dbj|BAB17220.1| serine/threonine kinase cdc2 [Oryzias javanicus]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAIREVSLLQEL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKN-TFPKWKEGS------LSSMVKNLDKNGLDLLAKMLTYNPPKRVSAREAMTHPYFDDLD-------KSTLPAASINGV------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|73946741|ref|XP 533555.2| PREDICTED: similar to cell cycle related kinase isoform 1 [Canis familiaris]'                          -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGVVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIEDNQHVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LVQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCILGELLNGSPLFPGENDIEQLCCVLRILGTPS-PQVWPEITELPDYNKISFKEQAPVP------LEEVLPDASPQALDLLGRFLLYPPHQRISASQALLHQYFFTAP-------LPAHPSELPIPQRPGGPAPKAHSGPPHVHDFRVDRPLEESLLNPELIRPFIPEG------------------------------------------------------------------------------------------------------   [346]
'gi|84028813|sp|Q4KM34|CCRK RAT Cell cycle-related kinase'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIEDSQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPS-PRVWPEITELPDYNKISFKEQAPVP------LEEVLPDASHQALDLLGQFLLYPPRQRIAASQALLHQYFFTAP-------LPAHPSELPIPQRPGGPTPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG------------------------------------------------------------------------------------------------------   [346]
'gi|21619542|gb|AAH31907.1| Cell cycle related kinase [Mus musculus] >gi|9664926|gb|AAF89089.1| CDK-related protein kinase PNQLA'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEIEDSQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPS-PRVWPEITELPDYNKISFKEQAPVP------LEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYFFTAP-------LPAHPSELPIPQRPGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG------------------------------------------------------------------------------------------------------   [346]
'gi|1705675|sp|P51958|CDC2 CARAU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1)'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRN-KTTGQVVAMKKI-----R----LESE-------EEGVPSTAVREISLLKEL-QHPNVVRLL-DVLM--QE-SK-LYLVFEFL-SMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NEVWPDVESLPDYKN-TFPKWKSGN------LASTVKNLDKNGIDLLTKMLIYDPPKRISARQAMTHPYFDDLD-------KSTLPASNLKI-------------------------------------------------------------------------------------------------------------------------------------------------   [302]
'gi|55731116|emb|CAH92273.1| hypothetical protein [Pongo pygmaeus] >gi|75070591|sp|Q5R7I7|CCRK PONPY Cell cycle-related kinase'      -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQALREIKALQEMEDNQYVVQLK-AVFP--HS-AG-FVLAFEFM-LSDLAEVVRHAQRP--LAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPN-PQVWPELTELPDYNKISFKEQAPVP------LEEVLPDASPQALDLLGQFLLYPPRQRIAASKALLHQYFFTAP-------LPAHPSELPIPQRLGVPAPKAHPGPPRIHDFYVDRPLEESLLNPELIRPFILEG------------------------------------------------------------------------------------------------------   [346]
'gi|49526555|emb|CAG60179.1| unnamed protein product [Candida glabrata CBS138] >gi|50289629|ref|XP 447246.1| unnamed protein pro'    -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERAEYTKEKKVGEGTYAVVY--------VGTK-QSTGRRIAVKEI-----K----TSEF-------KDGLDMSAIREVKYLQEM-QHVNVIELV-DIFM--SY-GN-LNLVLEYL-PTDLEVVIKDKSIL--FTPADIKSWMLMSVRGVHHCHRNFILHRDLKPNNLLIAPD-GQIKVADFGLARAVPSPH------EVLTSNVVTRWYRAPELLFGAKHYTSAIDVWSLGVIFAELMLRIPYLPGQNDLEQMEVTFRALGTPT-DKDWPEVSSFNSYNK--LQMYPPPS---RDELRKRFIAATENALNFMNGMMCLNPAKRWSTAQCLESEYFKELP-------RPSDPATIDITRKE----------------------------------------------------------------------------------------------------------------------------------------------   [307]
'gi|21263450|sp|Q9DG98|CDC2 ORYLU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKN-TFPKWKGGS------LSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLD-------KSTLPAACINGV------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|100916|pir||B40444 protein kinase (EC 2.7.1.37) cdc2 homolog B - maize  (fragment)'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KTANETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-NHGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRNNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQGWPGVSCLPDFKT-AFPRWQAQD------LATIVPNLEPAGLDLLSKMLRYEPSKRITARQALEHEYFKDLE-------MVQ---------------------------------------------------------------------------------------------------------------------------------------------------------   [294]
'gi|21263457|sp|Q9DGD3|CDC2 ORYLA Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKN-TFPKWKEGS------LSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLD-------KSTLPAACINGV------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|83754642|pdb|2C4G|C Chain C, Structure Of Cdk2-Cyclin A With Pha-533514 >gi|83754640|pdb|2C4G|A Chain A, Structure Of Cdk2-C'    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPLVDMENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRLERPHRD----------------------------------------------------------------------------------------------------------------------------------------------   [309]
'gi|21263453|sp|Q9DGA2|CDC2 ORYJA Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKN-TFPKWMEGS------LSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLD-------KSTLPAACINGV------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|66805759|ref|XP 636601.1| CDC2-like protein [Dictyostelium discoideum AX4] >gi|60464959|gb|EAL63070.1| CDC2 related protein'     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEKYSKIEKLGEGTYGIVY--------KAKN-RETGEIVALKRI-----R----LDSE-------DEGVPCTAIREISLLKEL-KHPNIVRLH-DVIH--TE-RK-LTLVFEYL-DQDLKKYLDECGGE--ISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRK-GELKLADFGLARAFGIPV------RTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMASGRPLFPGSGTSDQLFRIFKILGTPN-EESWPSITELPEYKT-DFPVHPAHQ------LSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALKHPYFDGLE-------PIN---------------------------------------------------------------------------------------------------------------------------------------------------------   [292]
'gi|21263456|sp|Q9DGA5|CDC2 ORYCU Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYVKIEKIGEGTYGVVY--------KGRH-KSTGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQEL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLSRAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPDVESLPDYKS-TFPKWKGGS------LSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLD-------KSTLPAACINGV------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|76779670|gb|AAI06637.1| Unknown (protein for MGC:132167) [Xenopus laevis]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDGSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSD-GAIKLADFGLARAFGVPV------RTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWPGVTTMPDYKS-TFPKWIRQD------FSKVVPPLDEDGRDLLAQMLQYDSNKRISAKVALTHPFFRDVS-------RPTPHLI-----------------------------------------------------------------------------------------------------------------------------------------------------   [297]
'gi|64666|emb|CAA32443.1| Eg1 [Xenopus laevis] >gi|1168866|sp|P23437|CDK2 XENLA Cell division protein kinase 2 (CDC2 homolog Eg1'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDRSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSD-GAIKLADFGLARAFGVPV------RTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWPGVTTMPDYKS-TFPKWIRQD------FSKVVPPLDEDGRDLLAQMLQYDSNKRISAKVALTHPFFRDVS-------RPTPHLI-----------------------------------------------------------------------------------------------------------------------------------------------------   [297]
'gi|89903018|ref|NP 001034892.1| cell cycle related kinase isoform 3 [Homo sapiens] >gi|23344742|gb|AAN28684.1| cell cycle relat'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGFPNQALREIKALQEMEDNQYVVQLK-AVFP--HG-GG-FVLAFEFM-LSDLAEVVRHAQRP--LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPN-PQVWPELTELPDYNKISFKEQVPMP------LEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAP-------LPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG------------------------------------------------------------------------------------------------------   [346]
'gi|60652228|gb|AAS59851.2| cyclin-dependent kinase 1 [Anabas testudineus]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDYLKIEKIGEGTYGVVY--------KGRH-KATGQVVAMKKI-----R----LESE-------EEGVPSTAVREVSLLQGL-KHPNVVRLL-DVLM--QE-SR-LYLIFEFL-SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NDVWPEVESLPDYKN-TFPKWKSGN------LASMVKNLDKNGLDLLAKMLTYNPPKRISAREAMTHPYFDDLD-------KSTLPAASINKI------------------------------------------------------------------------------------------------------------------------------------------------   [303]
'gi|54043093|gb|AAV28534.1| cell-division-cycle-2 kinase; cyclin-dependent kinase [Saccharum officinarum]'                           -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KGLD-KATNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-NHDNIVRLH-DVIH--SE-KR-IYLVFEFL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRFLHRDLKPQNLLIDRRTNTLKLADFGLSRAFGIPV------RTFTHEVVTLWYRAPEILLGAKQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQSWPGVSCLPDFKT-AFPRWQAQD------LATIVPNLEPAGLDLLSKMLRYEPSKRITARQALEHEYFKDLE-------MVQ---------------------------------------------------------------------------------------------------------------------------------------------------------   [294]
'gi|115923|sp|P23111|CDC2 MAIZE Cell division control protein 2 homolog (p34cdc2) >gi|168511|gb|AAA33479.1| protein cdc2 kinase'     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KATNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-NHGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPN-EQSWPGVSCLPDFKT-AFPRWQAQD------LATVVPNLDPAGLDLLSKMLRYEPSKRITARQALEHEYFKDLE-------VVQ---------------------------------------------------------------------------------------------------------------------------------------------------------   [294]
'gi|76625139|ref|XP 588152.2| PREDICTED: similar to cell cycle related kinase isoform 1 [Bos taurus]'                                -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYCILGRIGEGAHGIVF--------KAKH-VETGEIVALKKV-----A----LRRL-------EDGIPNQVLREIKALQEIEDSQYVVQLK-AVFP--HG-AG-FVLAFEFM-LSDLAEVVRHTQRP--LAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS-GQLKIADFGLARVF-SPD----GNRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCILGELLNGSPLFPGENDIEQLCCVLRILGTPS-PQVWPEITELPDYNKISFKEQAPVP------LEEVLPDASPQALDLLGRFLLYPPQQRISASQALLHHYFFTAP-------LPVHPSELPIPQRPGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG------------------------------------------------------------------------------------------------------   [346]
'gi|50549857|ref|XP 502400.1| hypothetical protein [Yarrowia lipolytica] >gi|49648268|emb|CAG80588.1| unnamed protein product [Y'    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNDAVMAKYTKDKKVGEGTFAVVY--------VGKQ-VKTDRKIAIKQI-----K----EGEF-------KDGVDMSAIREIKFLQEI-RHANVIELI-DVFT--AG-PR-LSMVLEFL-PTDLEGLIKDTKIL--FRLGDVKAWMLMATRGLHHCHRLQILHRDLKPNNLLISPT-GELKIADFGLARQMPNPK------DKMTPTVVTRWYRAPELLFGARYYTPAVDVWSLGLIFAELMLRLPYCPGEDDIDQIDKTFRAFGTPT-EEEWPGLTSLPAYPK-TVNKYPHPS---VQELKMRFSAATENGLELFQAMTELNPADRVSCEEALTADYFTEFP-------RPTKLAELPGRTE-----------------------------------------------------------------------------------------------------------------------------------------------   [310]
'gi|51704177|gb|AAH81346.1| MGC89594 protein [Xenopus tropicalis] >gi|56118390|ref|NP 001008136.1| MGC89594 protein [Xenopus tro'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-RETGEIVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-NQDLKKFMDGSNISG-ISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD-EVSWPGVTTMPDYKS-TFPKWVRQD------FSKVVPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFFRDVS-------RPTPHLI-----------------------------------------------------------------------------------------------------------------------------------------------------   [297]
'gi|100915|pir||A40444 protein kinase (EC 2.7.1.37) cdc2 homolog A - maize'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKVEKIGEGTYGVVY--------KALD-KTANETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-NHGNIVRLH-DVVH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPN-EQSWPGVSCLPDFKT-AFPRWQAQD------LATVVPNLDPAGLDLLSKMLRYEPSKRITARQALEHEYFKDLE-------VVQ---------------------------------------------------------------------------------------------------------------------------------------------------------   [294]
'gi|50927146|gb|AAH79527.1| Cell division cycle 2 [Danio rerio] >gi|31323425|gb|AAP47014.1| cell division control protein 2 [Dan'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDYLKIEKIGEGTYGVVY--------KGRN-KTTGQVVAMKKI-----R----LESE-------EEGVPSTAVREISLLKEL-QHPNVVRLL-DVLM--QE-SK-LYLVFEFL-SMDLKKYLDSIPSGEFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPV------RVYTHEVVTLWYRAPEVLLGASRYSTPVDLWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN-NEVWPDVESLPDYKN-TFPKWKSGN------LANTVKNLDKNGIDLLMKMLIYDPPKRISARQAMTHPYFDDLD-------KSSLPASNLKI-------------------------------------------------------------------------------------------------------------------------------------------------   [302]
'gi|72159035|ref|XP 790847.1| PREDICTED: similar to Cell division protein kinase 2 [Strongylocentrotus purpuratus]'                  ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDNGLAHVKMNNFEKIEKIGEGTYGVVY--------KARD-LKSGKTVALKKI-----R----LDTE-------SEGVPSTAIREIALLKEL-DHKNIVKLH-DVVH--SD-KK-LYLVFEFM-NQDLKKYMDVAPPSG-LPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDAD-GRIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMITRRALFPGDSEIDQLFRIFRTMGTPD-EKLWPGVTSLPDYKT-SFPRWTPQD------FTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYFKDVK-------MV-PPPRLPT--------------------------------------------------------------------------------------------------------------------------------------------------   [308]
'gi|62460564|ref|NP 001014934.1| cyclin-dependent kinase 2 [Bos taurus] >gi|75070062|sp|Q5E9Y0|CDK2 BOVIN Cell division protein'     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAD-GSIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|20343|emb|CAA42922.1| Rcdc2-1 [Oryza sativa (japonica cultivar-group)] >gi|231706|sp|P29618|CDC21 ORYSA Cell division contro'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQYEKEEKIGEGTYGVVY--------RARD-KVTNETIALKKI-----R----LEQE-------DEGVPSTAIREISLLKEM-HHGNIVRLH-DVIH--SE-KR-IYLVFEYL-DLDLKKFMDSCPEFA-KNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPV------RTFTHEVVTLWYRAPEILLGSRQYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTPN-EQSWPGVSSLPDYKS-AFPKWQAQD------LATIVPTLDPAGLDLLSKMLRYEPNKRITARQALEHEYFKDLE-------MVQ---------------------------------------------------------------------------------------------------------------------------------------------------------   [294]
'gi|34809870|pdb|1OIT|A Chain A, Imidazopyridines: A Potent And Selective Class Of Cyclin-Dependent Kinase Inhibitors Identified'    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLSFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [299]
'gi|66521038|ref|XP 393450.2| PREDICTED: similar to cyclin dependent kinase 2 [Apis mellifera]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDNFVKIEKIGEGTYGVVY--------KAKD-KLTGKLVALKKI-----R----LE---------TEGVPSTAIREISLLREL-THPNIVQLF-DVVD--GD-NH-LYLVFEFL-QQDLKKLLDSVKGG--LDQALVKSYLYQLLKAISFCHLHCILHRDLKPQNLLIDQE-GHIKLADFGLARTFGVPV------RTYTHEIVTLWYRAPEILLGTKLYSNAVDVWSLGCIFAEMATRRALFPGDSEIDQLFRIFRTLGTPD-ENIWPGVSQLRDYTS-MFPRWEPRP------LDEVVPSFDSDAKDLLLKLLTYDPNQRITAKKGLSHPYFNGVT-------LVPPP--LPKKT------------------------------------------------------------------------------------------------------------------------------------------------   [297]
'gi|29849|emb|CAA43807.1| CDK2 [Homo sapiens]'                                    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGSKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|38197708|gb|AAH61832.1| Cyclin-dependent kinase 2 [Rattus norvegicus] >gi|7949020|ref|NP 058036.1| cyclin-dependent kinase 2'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAE-GSIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|73968309|ref|XP 856049.1| PREDICTED: similar to cyclin-dependent kinase 2 isoform 6 [Canis familiaris]'                          -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KAKN-KVTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
'gi|13111756|gb|AAH03065.1| Cyclin-dependent kinase 2, isoform 1 [Homo sapiens] >gi|16936528|ref|NP 001789.2| cyclin-dependent k'    -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENFQKVEKIGEGTYGVVY--------KARN-KLTGEVVALKKI-----R----LDTE-------TEGVPSTAIREISLLKEL-NHPNIVKLL-DVIH--TE-NK-LYLVFEFL-HQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPV------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSMPDYKP-SFPKWARQD------FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT-------KPVPHLRL----------------------------------------------------------------------------------------------------------------------------------------------------   [298]
;
END;


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