#NEXUS 
[MacClade 4.08 registered to Tomoaki Nishiyama, National Institute for Basic Biology]


BEGIN DATA;
	DIMENSIONS  NTAX=83 NCHAR=1648;
	FORMAT DATATYPE=PROTEIN  SYMBOLS = " 1 2 3 4"  MISSING=? GAP=- ;
MATRIX
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'gi|15224430|ref|NP 181340.1| DET2 (DE-ETIOLATED 2) [Arabidopsis thaliana] >gi|19310675|gb|AAL85068.1| putative 3-oxo-5-alpha-st'    -----MEEIADKT-------------------------------------------------------------------------------------FFRYCLLTLIFAGPPTAVLL--KFLQA-----------PYGKH------NRTG-------WGP---TVSPPIAW---F-VMESP--TLWLTLLLFPFGRHA---------------------------------------------LNPKSLLLF---SPYLIHYFHR------------TIIYPLRLFRSSF-------PAGK-NGFPI-TIAALAFT---FNLLNGY-IQARWVS------HYK--DDY------------------------------------------------EDGN-------WFWWRFVIGMVVFITGMYINITSDRTLVRLKKENR-----------------------------------------G-GYVIPRGGWFELVSCPNYFGEAIEWLGWAVM-T--------------------------------------------------------WS----------W-AGIGFFLYTCSNLFPRARASHK------WYIAKFKEEYPK-TRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [262]
'gi|1280611|gb|AAC49264.1| steroid reductase DET2 [Arabidopsis thaliana]'                                    -----MEEIADKT-------------------------------------------------------------------------------------FFRYCLLTLIFAGPPTAVLL--KFLQA-----------PYGKH------NRTG-------WGP---TVSPPIAW---F-VMESP--TLWLTLLLFPFGRHA---------------------------------------------LNPKSLLLF---SPYLIHYFHR------------TIIYPLRLFRSSF-------PAGK-NGFPI-TIAALAFT---FNLLNGY-IQARWVS------HYK--DDY------------------------------------------------EDGN-------WFWWRFVIGMVVFITGMYINITSDRTLVRLKKENR-----------------------------------------G-GYVIPRGGWFELVSRPNYFGEAIEWLGWAVM-T--------------------------------------------------------WS----------W-AGIGFFLYTCSNLFPRARASHK------WYIAKFKEEYPK-TRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [262]
'gi|73761693|gb|AAZ83346.1| steroid 5-alpha-reductase [Gossypium hirsutum]'                                    -------MASDQT-------------------------------------------------------------------------------------LFHYCLLTLYIIALPTWISL--YFLQA-----------PYGKH------NRPG-------WGP---TISPPLAW---F-LMESP--TLWLTFFLFPSGQHF---------------------------------------------YNPKSFLLI---SPFLFHYFNR------------TVLYPLRLARN---------TTQT-RGFPV-SVAFMAFG---FNLLNGY-LQARWVS------HYK--DDY------------------------------------------------ENEE-------LFWWRFLAGLLIFVVGMWVNVRADKVLVGLKKQGD-----------------------------------------G-GYKIPRGGLFELVSCPNYFGEIMEWFGWAVM-T--------------------------------------------------------WS----------W-VGFGFFLYTCANLMPRARATRL------WYLEKFKDDYPK-DRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [258]
'gi|50403823|gb|AAT76665.1| 5-alpha-reductase [Pisum sativum]'                                    -MLNQKIFLQDDS-------------------------------------------------------------------------------------LFNYALLTLFLIAPPTFISL--AFLQA-----------PYGKH------HRPG-------WGP---NLSPPLAW---F-LMESP--TLWFTLYLFPFGNNS---------------------------------------------SNPKSIILI---TPFLIHYFNR------------TIIYPVRLFITMKTKKKSTLSKTP-SGFPF-SIALMAFV---FNLLNSY-VQARWVS------HYK--S-Y------------------------------------------------DDGL-------FFWVVFFCGVLVFSGGMGINVWSDKELLRLKGEGK-------------------------------------------GYVVPKGGFFEFVSCPNYFGEIVEWFGWALM-T--------------------------------------------------------WS----------W-AGLGFFAYTFANLGPRARANHQ------WYLEKFGEDYPK-KRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [271]
'gi|11493760|gb|AAG35638.1| putative steroid reductase [Glycine max]'                                    ---MIPEHYSDSS-------------------------------------------------------------------------------------LFHSSLLTLFLIAPPTFFSL--TFLQA-----------PYGKH------HRPG-------WGP---NLPPPLAW---L-LMESP--TLWLTLLLFPLGLHS---------------------------------------------HNPKAQALI---TPFLIHYFNR------------TILYPLHLLLTPS-------KKTT-PGFPL-SVALMAFA---FNVLNSY-LQARTVS------HYN--NHY------------------------------------------------DDSG-------FFWFRFLCGLLVFLLGMGINVWADRVLLRLKSEGK-------------------------------------------GYVVPRGGLFELVACPNYFGEIVEWLGWAVM-T--------------------------------------------------------WS----------W-AGLGFFVYTFANLGPRARANRR------WYLEKFGEDYPK-ERKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [263]
'gi|34850849|dbj|BAC87862.1| steroid 5alpha-reductase [Ipomoea nil]'                                    MMSIREVMESDQW-------------------------------------------------------------------------------------LFRHSVFVLLLIAPPVYIAC--RFITA-----------PFGKH------VRPG-------WGP---TISPPLAW---F-LMESP--AIWLTLLLFPFGRSS---------------------------------------------SNPLAQILM---APYLLHYAHR------------TIVYPLRLYLNSDP------RRAA-AGFPV-SVALMAFT---FNILNAY-LQTRWVS------HYA--D-Y------------------------------------------------EGGG-------LFWWRFACGMAVFLAGMAVNVWADKVLLRLKSEG------------------------------------------G-GYKIPRGGLYEYVSCPNYFGEILEWLGWFLM-T--------------------------------------------------------WS----------A-AGFAFFLFTCANLMPRAWSHRQ------WYLEKFGEDYPR-KRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [266]
'gi|57335416|emb|CAH05260.1| steroid 5 alpha reductase DET2 [Lycopersicon esculentum]'                                    ------MFSSDEN-------------------------------------------------------------------------------------LFNFIVFFILVMAFPTFILC--QFFTS-----------PYGKH-----YTSAD-------SGT---TISPPIAW---A-FMESP--TLWLTIIVFRLGKNY---------------------------------------------TNPLAFLLI---SPYLFHYTNR------------TIIYPLRLRS----------RNTK-NNFPL-NIAVTAFI---FNLLNAY-IQSRWVS------HYA--N-Y------------------------------------------------QEDD-------WFWVRFGIGLVIFGSGMLLNIWADGVLLGLKSQG------------------------------------------G-GYKIPRGGLFDYVSSPNYLGEIMEWLGWALM-T--------------------------------------------------------WS----------W-AGLAFFVYTCANLVPRAVSNHK------WYLQKFGEDYPK-NRKAVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [257]
'gi|34908346|ref|NP 915520.1| putative steroid reductase DET2 [Oryza sativa (japonica cultivar-group)] >gi|20805184|dbj|BAB92853'    ----MGGGGGDDA-------------------------------------------------------------------------------------LYARCLVILYLISPITVFLL--RFVSA-----------PYGKL------SRPG-------WGP---AVPAALAW---F-LMESP--TMCLPPLVLSAAASSSA-------------------------------------------LRAAALLPA---ALYALHYVNR------------TLVHPLRLLRL---------RRAP-APVPI-LVAAFAFG---FNLLNAY-VQARSWALDAAAPHSTATA--------------------------------------------------TATP-------AAVARCLVGLALFAWGMRTNIAADKALLRLKEAGK-------------------------------------------GYQIPRGGLFDVVTCPNYFGEAVEWLGYALV-A--------------------------------------------------------WT----------P-AAWAFFLYTCSNLGPRARDHRR------WYVGKFGDKYPA-SRKAFV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [268]
'gi|62954889|gb|AAY23258.1| 3-oxo-5-alpha-steroid 4-dehydrogenase, putative [Oryza sativa (japonica cultivar-group)] >gi|7754905'    ----MAMGSSDGDV------------------------------------------------------------------------------------LYARCLVTLYLLSPLNVFAL--WFMSA-----------PYGKL------SRPG-------WGP---TVPAALAW---C-LMESP--TLWLPPLVLSATTTSLSTP-----------------------------------------TLRVTILPA---ALYMLHYVHR------------TLVHPLRLLRL---------RRAP-APMPI-LIIMFGFS---FNLLNAY-IQARSWALDAVPPA-------------------------------------------------------TATP-------LTVARCLVGLALFVWGMWTNIAADRELLRLKEAGK-------------------------------------------GYQIPKDGLFDLVACPNYFGETVEWLGYALV-A--------------------------------------------------------WT----------P-AAWAFFLYTCVNLGPRARDQRL------WYISKFGDKYPA-SRKAFI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [266]
lcl|Smo_DET2_1_2_unnamed_protein_product                                    ----MEEEQ-----------------------------------------------------------------------------------------WYWKALWLNIILAFSTAASL--TRITA-----------PYGRH------TQAGASSSLDVWGP---SMPARDGW---V-LMESP--ALWFTLLVFSAGKHA---------------------------------------------SETVPLVLL---RLFQLHYTHR------------ALIYPFRM------------RSRG-KTISI-AIVALSFV---FNIYNGY-LQARWLS------EFG---IY------------------------------------------------PDTW-------LRSPQFVSGSLLFAAGMVTNVWADSVLISLRKPGE---------------------------------------ERG-GYKLPQGWLFSLVACPNYSGEILEWLGWALL-T--------------------------------------------------------WS----------P-AGLVFFIFTAANLIPRAVAHRR------WYVSKFP-EFPA-SRRAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [261]
lcl|Smo_DET2_12_1_unnamed_protein_product                                    ----MEEEQ-----------------------------------------------------------------------------------------WYWKALWLNIILAFSTAASL--TRITA-----------PYGRH------TQAAPSSSLDVWGP---SMPARDGW---V-LMESP--ALWFTLLVFSAGKHS---------------------------------------------SETVPLVLL---RLFQLHYTHR------------ALIYPFRM------------RSRG-KTISI-AIVALSFV---FNIYNGY-LQARWLS------EFG---TY------------------------------------------------PDTW-------LRSPQFISGSLLFAAGMVTNVWADSVLISLRKPGE---------------------------------------ERG-GYKLPQGWLFSLVACPNYSGEILEWLGWALL-T--------------------------------------------------------WS----------P-AGLVFFIFTAANLIPRAVAHRR------WYVSKFP-EFPA-SRRAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [261]
lcl|Smo_DET2_2_1_unnamed_protein_product                                    ----MKEES-----------------------------------------------------------------------------------------VFQFLVWIQFVRAALSFRRP--VGIQT------------YGRH------LAPR-------LSA-MPTLPSHLGW---L-LMEAP--TLLVPALIFHRGKHA---------------------------------------------AAAAPRLLL---LLFLAHYFHR------------TLLYPLRLSRR---------SSSS-TPMPL-VTAVLAAL---FNALNTY-IQLRWIS------HFG---FY------------------------------------------------PERW-------IHSAQFAIGAFLFVAGMAINIWADGVLIALRKQRS------------------------------------SAKESV-SYRVPYGGLYEFVSCPNYLGEIVEWLGWAIL-T--------------------------------------------------------WS----------P-AGLGFFLYTVATLAPRACAHHR------WYVDKFP-DYPR-GRTPLI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [261]
lcl|Smo_DET2_6_2_unnamed_protein_product                                    ----MKEES-----------------------------------------------------------------------------------------VFQFLVWIQFVRAALSFRRP--VGIRT------------YGRH------LTPR-------LSA-LPTLPSHLGW---L-LMEAP--TLLVPALIFHRGKHA---------------------------------------------ATAAPRLLL---LLFLAHYFHR------------TLLYPLRLSRR---------SSSS-TPMPL-VTAVLAAL---FNALNTY-IQLRWIS------HFG---FY------------------------------------------------PERW-------IRSAQFAIGAFLFVAGMAINIWADGVLIALRKQRS------------------------------------SAKDSV-SYRVPYGGLYEFVSCPNYLGEIVEWLGWAIL-T--------------------------------------------------------WS----------P-AGLGFFLYTVATLAPRACAHHR------WYVDKFP-DYPR-GRTPLI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [261]
lcl|Ppa_DET2_1_1_unnamed_protein_product                                    ----MEEAAGDEE-------------------------------------------------------------------------------------WYTIALWGYFAMAAIMFVLVN-FCLSA-----------PYGRH------VRRG-------WGF---SVP----------VQSCD-----------NFGRVS---------------------------------------------IAKAFEFIA---PMHQMHYFHR------------TLVFPFRM------------RADG-KAMPA-AVVASGFF---FNVYNSY-IQARWIS------HIG---VY------------------------------------------------PSSW-------LTSPQFLLGVAIFLVGFLGNIWADNVLLNLRDHKE----------------------------------------DR-SYKIPRGFLYEFITCPNYFCEIIEWLGWAIA-T--------------------------------------------------------NS----------V-AGFFFFLSTLANLGPRAKTHHE------WYHKKFN-DYPR-NRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [243]
'gi|3877047|emb|CAA92173.1| Hypothetical protein F42F12.3 [Caenorhabditis elegans] >gi|17567677|ref|NP 510071.1| F42F12.3 [Caeno'    ----M-----------------------------------------------------------------RE--------------------------TILMMAWAMIGTAFFVFFALK-MGLTA-----------GYGRY------TNQA-------QW----GINPKLAW---F-IQESP--AFFIPFYFLFGGLS------------------------------------------------STGRILN---CIFLVHYFYR------------ALIYPFRI-------------RST-TKSPL-LIVAAAVA---FCTYNGT-LQGVWNS------YYQ-----------------------------------------------------LEE--------ELTYRHLIGSILYFSGMFINHKSDNILMTLRKPGE-----------------------------------------T-GYKIPTGFLYEYISCPNYFGEIMEWIGYAIL-G--------------------------------------------------------WN----------L-PALAFAIFTFANIGPRAIAHHN------WYKEKFP-KYPP-TRRALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [243]
'gi|49900198|gb|AAH76920.1| Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)'    ----MSLSALV--------------------------------------------------------GDEAQ--------------------------LLNLLAMFMALMGLVSYVSL--QYIRM-----------PYGRY------ADSA-------FGP---PVPVRLAW---F-VQEVP--SLSVSLFFYLRQTE----------------------------------------------FSIANQVLM---GAFICHYTQR------------TLIFPFLI-------------RGG-KPTPF-ASFALAFI---FCCYNGY-LQSSYLC------SHA--A-Y------------------------------------------------ASDW-------IHDPRFITGIMLFFCGMFINIYSDRILRNLRKPGE-----------------------------------------M-GYKIPKGGLFDYVSGANFFGEIVEWSGFALA-G--------------------------------------------------------WS----------L-PAAAFAIFTAFVLTSRAQQHHK------WYLEKFE-DYPK-NRKILV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [257]
'gi|206838|gb|AAA42102.1| steroid 5 alpha-reductase (EC 1.3.99.5) >gi|77404421|ref|NP 058766.2| steroid 5 alpha-reductase 1 [Rat'    ----ME--------LDELC-------------------------------------------------------------------------------LLDMLVYLEGFMAFVSIVGL--RSVGS-----------PYGRY------SPQW-------PGI---RVPARPAW---F-IQELP--SMAWPLYEYIRPAAARL-------------------------------------------GNLPNRVLL---AMFLIHYVQR------------TLVFPVLI-------------RGG-KPTLL-VTFVLAFL---FCTFNGY-VQSRYLS------QFA--V-Y------------------------------------------------AEDW-------VTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE-----------------------------------------T-GYKIPRGGLFEYVSAANYFGELVEWCGFALA-S--------------------------------------------------------WS----------L-QGVVFALFTLSTLLTRAKQHHQ------WYHEKFE-DYPK-SRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [255]
'gi|1336835|gb|AAB36218.1| type I 5 alpha-reductase [Rattus sp.] >gi|2507119|sp|P24008|S5A1 RAT 3-oxo-5-alpha-steroid 4-dehydrog'    MVPLME--------LDELC-------------------------------------------------------------------------------LLDMLVYLEGFMAFVSIVGL--RSVGS-----------PYGRY------SPQW-------PGI---RVPARPAW---F-IQELP--SMAWPLYEYIRPAAARL-------------------------------------------GNLPNRVLL---AMFLIHYVQR------------TLVFPVLI-------------RGG-KPTLL-VTFVLAFL---FCTFNGY-VQSRYLS------QFA--V-Y------------------------------------------------AEDW-------VTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE-----------------------------------------T-GYKIPRGGLFEYVSAANYFGELVEWCGFALA-S--------------------------------------------------------WS----------L-QGVVFALFTLSTLLTRAKQHHQ------WYHEKFE-DYPK-SRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [259]
'gi|87044895|ref|NP 780492.2| steroid 5 alpha-reductase 1 [Mus musculus] >gi|51259759|gb|AAH79863.1| Srd5a1 protein [Mus musculu'    ----ME--------LDELR-------------------------------------------------------------------------------LLDALVYLEGFLAFVAFVGL--QMVGS-----------SYGRY------SSQW-------SGR---RVPARPAW---F-LQELP--SMAWPLYECIRPAAARL-------------------------------------------GNLPNRVLL---AMFLIHYVQR------------TLVFPVLI-------------RGG-KPTLL-FTFVLAFL---FCTLNGY-LQSRYLS------QFA--V-Y------------------------------------------------AEDW-------VTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE-----------------------------------------T-GYKIPRGGLFEYVSSANYFGELVEWCGFALA-S--------------------------------------------------------WS----------L-QGVVFALFTLCALFTRARQHHQ------WYLEKFE-DYPK-TRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [255]
'gi|63101468|gb|AAH94503.1| Srd5a1 protein [Mus musculus]'                                    ----ME--------LDELC-------------------------------------------------------------------------------LLDALVYLEGFLAFVAFVGL--QMVGS-----------SYGRY------SSQW-------SGR---RVPARPAW---F-LQELP--SMAWPLYECIRPAAARL-------------------------------------------GNLPNRVLL---AMFLIHYVQR------------TLVFPVLI-------------RGG-KPTLL-FTFVLAFL---FCTLNGY-LQSRYLS------QFA--V-Y------------------------------------------------AEDW-------ITHPCFLTGFALWLVGMVINIHSDHILRNLRKPGD-----------------------------------------T-GYKIPRGGLFEYVSSANYFGELVEWCGFALA-S--------------------------------------------------------WS----------L-QGVVFALFTLCALFTRARQHHQ------WYLEKFE-DYPK-TRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [255]
'gi|67474827|ref|XP 653147.1| steroid 5-alpha reductase [Entamoeba histolytica HM-1:IMSS] >gi|56470073|gb|EAL47759.1| steroid 5-'    ----MNSES-----------------------------------------------------------------------------------------IYYLFLLVMVILGFIVFVLL--HYVTA-----------GYGMF------QTDK-------WGV---TINNRIGW---C-IMEIV--SMIGMLIFYVYSSV----------------------------------------------DEIVPIISL---ILFVIHYFRR------------SIIFPLRM-------------SKG-GKMPI-IIMLMGMV---FNLCNCY-VQAGWLF------LYHPPHYY-------------------------------------------------LGW-------FNTPQCYFGVLVFFVGMAINVHSDEIIRNLRKEGE-----------------------------------------T-EHKLPQGGLFDYVTSAQYFGELVEWLGFSIF-T--------------------------------------------------------LS----------P-GAIVFFLWTFANLMPRARSVHL------AYRRKFKNQVG--DRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [252]
'gi|999036|gb|AAB34212.1| steroid 5 alpha-reductase type 1 isoenzyme; SR type 1 [Macaca fascicularis] >gi|2498887|sp|Q28891|S5A1'    ----MATAVAEELLLAEER-------------------------------------------------------------------------------MLAALAYLQCAVGCAVLARN--RETNL-----------AYGRH------ASPS-------FRV---RVPARAAW---V-VQELP--SLALPLYQYASESAPRL-------------------------------------------RSAPNCILL---AMFLVHYGHR------------CLIYPFLM-------------RGG-KPMPL-LACTMAIM---FCTFNGY-LQSRYLS------HWA--V-Y------------------------------------------------ADDW-------VTDPRFLIGFGLWLAGMLINIHSDHILRNLRKPGD-----------------------------------------T-GYKIPRGGLFEYVTAANYFGEIMEWCGYALA-S--------------------------------------------------------WS----------V-QGAAFAFFTFCFLSGRAKEHHR------WYLQKFE-EYPK-FRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [263]
'gi|30583847|gb|AAP36172.1| Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydroge'    ----MATATG----VAEER-------------------------------------------------------------------------------LLAALAYLQCAVGCAVFARN--RQTNS-----------VYGRH------ALPS-------HRL---RVPARAAW---V-VQELP--SLALPLYQYASESAPRL-------------------------------------------RSAPNCILL---AMFLVHYGHR------------CLIYPFLM-------------RGG-KPMPL-LACTMAIM---FCTCNGY-LQSRYLS------HCA--V-Y------------------------------------------------ADDW-------VTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD-----------------------------------------T-GYKIPRGGLFEYVTAANYFGEIMEWCGYALA-S--------------------------------------------------------WS----------V-QGAAFAFFTFCFLSGRAKEHHE------WYLRKFE-EYPK-FRKIII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLFL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [260]
'gi|32891811|gb|AAP88935.1| steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)'    ----MATATG----VAEER-------------------------------------------------------------------------------LLAALAYLQCAVGCAVFARN--RQTNS-----------VYGRH------ALPS-------HRL---RVPARAAW---V-VQELP--SLALPLYQYASESAPRL-------------------------------------------RSAPNCILL---AMFLVHYGHR------------CLIYPFLM-------------RGG-KPMPL-LACTMAIM---FCTCNGY-LQSRYLS------HCA--V-Y------------------------------------------------ADDW-------VTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD-----------------------------------------T-GYKIPRGGLFEYVTAANYFGEIMEWCGYALA-S--------------------------------------------------------WS----------V-QGAAFAFFTFCFLSGRAKEHHE------WYLRKFE-EYPK-FRKIII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [259]
'gi|74003097|ref|XP 535799.2| PREDICTED: similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Steroid 5-alpha-reductase 1) (SR ty'    ----ME--------PAEVS-------------------------------------------------------------------------------RLHALAYLQCALGFLGSLLL--RQAAS-----------SYGRY------ASPG-------AAF---GVPARAAW---A-LQELP--SLAVPLWVCARTAAERL-------------------------------------------RRAPNRILL---AMFLLHYAQR------------SLIFPFLI-------------RGG-KPMPL-YTCVLAFT---FCVYNGY-LQSRYLS------QYA--V-Y------------------------------------------------ADDW-------VTDPRFLVGFCLWLIGMLINIHSDHILRNLRKPGE-----------------------------------------T-GYKIPRGGLFEYVTAANYFGEVVEWCGYGLA-S--------------------------------------------------------WS----------I-QGGAFALFTFCILLTRAQQHHR------WYLEKFE-DYPK-FRKIII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [255]
'gi|39588030|emb|CAE57261.1| Hypothetical protein CBG00143 [Caenorhabditis briggsae]'                                    ----MI-------------------------------------------------------------QLEEE--------------------------TILTMAWLMIASAIVVFAALR-FGLTA-----------GYGRY------TNTA-------RL----GISPRLAW---F-IQEAP--SFFIPFYYLFNGTS------------------------------------------------NSGHYLT---RVFLLHYFNR------------VFIFPLKI-------------RST-TVSPL-YIMLSAIF---FCCYNGF-MQGYWNA------FYQ-----------------------------------------------------PEEG-------ALTARHYIGSLLFFYGMYINHKADRILFNLRAPGE-----------------------------------------T-GYKIPEGWLYEHISCPNYFGEIVEWTGYAIM-A--------------------------------------------------------WN----------L-PALAFAIFTASNIGPRAISHHA------WYKEKFP-EYPP-HRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [248]
'gi|6523819|gb|AAF14869.1| steroid-5-alpha-reductase isoform [Homo sapiens]'                                    ----MATATG----VAEER-------------------------------------------------------------------------------LLAALAYLQCAVGCAVF-----------------------------------------------------------------------------------PRL-------------------------------------------RSAPNCILL---AMFLVHYGHR------------CLIYPFLM-------------RGG-KPMPL-LACTMAIM---FCTCNGY-LQSRYLS------HCA--V-Y------------------------------------------------ADDW-------VTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD-----------------------------------------T-GYKIPRGGLFEYVTAANYFGEIMEWCGYALA-S--------------------------------------------------------WS----------V-QGAAFAFFTFCFLSGRAKEHHE------WYLRKFE-EYPK-FRKIII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [211]
'gi|29339378|gb|AAO77175.1| 3-oxo-5-alpha-steroid 4-dehydrogenase [Bacteroides thetaiotaomicron VPI-5482] >gi|29347478|ref|NP 81'    ----MSIA------------------------------------------------------------------------------------------AFNLFLGVMSLTALIVFIAL--YFVKA-----------GYGIF------RTAS-------WGV---AISNKLAW---I-LMEAP--VFLVMCWMWIHSERR---------------------------------------------FDPVILTFF---VFFQIHYFQR------------AFVFPLLL-------------TGK-SKMPL-AIMSMGIL---FNLLNGY-MQGEWIF------YLSPEGMY------------------------------------------------HSGW-------FTSAWFIAGSLLFFAGMLMNWHSDYIIRHLRKPGD-----------------------------------------T-RHYLPQKGMYRYVTSANYLGEIIEWAGWAIL-T--------------------------------------------------------CS----------L-SGLVFFWWTVANLVPRANAIWH------RYREEFGSEVG--ERKRVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [253]
'gi|54018000|dbj|BAD59370.1| putative steroid dehydrogenase [Nocardia farcinica IFM 10152] >gi|54026492|ref|YP 120734.1| putativ'    ----MDWYTGNT--------------------------------------------------------------------------------------GYDTVLTIGFAFAAFVIVGG--LFAQS-----------PYGRF------APAS-------LGF---NLSPKLGW---W-LMELP--ATVVFAVFFLTGPDR---------------------------------------------FEPVPLVLA---GIWLLHYANR------------GWFFPLAIRQV---------PDKR-STFNV-SVLAAGMF---VTTLHGY-LNGAFFS-------HDYKHQY------------------------------------------------GTEW-------LTDPRFLIGLAGYLCGFALLVRSESIVRNLRDKRD--------------------------------------PGAA-EYRIPYGGGFRFVSSPAYLGELIAWAGFALL-T--------------------------------------------------------WS----------L-AGVVIFLITAGNLVPRAFATHR------WYREKFA-DYPR-NRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [263]
'gi|62955375|ref|NP 001017703.1| hypothetical protein LOC550398 [Danio rerio] >gi|62204922|gb|AAH93267.1| Hypothetical protein L'    ----MLCQEN----------------------------------------------------------------------------------------TVHFGSWAFVVGGLLYLLKQ--LTTQT-----------AYGRY------VDTK------SPGL---MVPARAGW---F-IQELP--SFLVPVLLFFATESL---------------------------------------------PGVGKHILF---WTFCLHYFQR------------TFVYSLLT-------------K-G-RPSPL-HIVVSAVV---FCSINGF-LQGHYML------HCT--Q-Y------------------------------------------------SSDW-------LTDTRFITGLLVFLCGMAINIHSDYILRNLRKPGE-----------------------------------------V-SYKIPRGGLFELVSGANFFGEIVEWCGYAVA-S--------------------------------------------------------WS----------F-PAFSFALFTICSIGPRAYHHHR------YYLEKFK-DYPK-SRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [252]
'gi|63100542|gb|AAH95069.1| Hypothetical protein LOC550398 [Danio rerio]'                                    ----MLCQEN----------------------------------------------------------------------------------------TVHFGSWAFVVGGLLYLLKQ--LTTQT-----------AYGRY------VDTK------SPGL---MVPARAGW---F-IQELP--SFLVPVLLFFATESL---------------------------------------------PGVGKHILF---WTFCLHYFQR------------TFVYSLLT-------------K-G-RPSPL-HIVVSAVV---FCSINGF-LQGHYML------HCT--Q-Y------------------------------------------------SSDW-------LTDTRFITGLLVFLCGMAINIHSDYILRNLRKPGE-----------------------------------------V-SYKIPRGGLFELVSGANFFGEIVEWCGYAVA-S--------------------------------------------------------WS----------F-PAFSFALFTICSIGPRAYHHHR------YYLEEFK-DYPK-SRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [252]
'gi|3876116|emb|CAA92168.1| Hypothetical protein F19H6.4 [Caenorhabditis elegans] >gi|17567167|ref|NP 510077.1| F19H6.4 [Caenorh'    ----M-----------------------------------------------------------------RE--------------------------ILLTMAWAMIGMAVIVFLALT-RGFTA-----------GYGRY------ADRS-------KY----GINPKLAW---F-IQEAP--AFFIPLYYLRRGPS------------------------------------------------NSGYELN---AAFLFHYFFR------------ALIYPCRI-------------RST-TKSPV-AIVAAATF---FCAYNGF-LQGYWNA------FYQ-----------------------------------------------------PEE--------PWTTRKLVGSLMYCTGMYINHKSDTILRELRADGG-----------------------------------------T-GYKIPTGFLYEYISCPNYAGEIMEWIGYSIL-A--------------------------------------------------------WN----------L-PALAFAIFTIANIGPRAVAHHK------WYKETFP-GYPP-NRRILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [243]
'gi|42528197|ref|NP 973295.1| 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Treponema denticola ATCC 35405] >gi|41819467'    ----MERLIF----------------------------------------------------------------------------------------IFNITQIVLFGVGLICFVVL--FFVPA-----------GYGKM------INKK-------WGF---SFNNKIAW---F-LMEVP--TLITMIVLMCVWAKP---------------------------------------------ENFVRIIIG---LFFVLHYAQR------------VFIFPFLL-------------KGK-SKMPI-LIVLMGIT---FNTINAF-LIGAWLF------YLSPKTMY------------------------------------------------PISW-------LYDPRFIIGALVFLLGMAINIDSDKYIRSLRKPGD-----------------------------------------T-AHYFPHKRMYKYVSSANYFGEILEWFGFALL-S--------------------------------------------------------WS----------F-VGLLFAFWTCANLVPRAYTINK------RYREEFPEEFAALKPKRVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [257]
'gnl|CMER|CMO284C probable 3-oxo-5-alpha-steroid 4-dehydrogenase'                                    ----MNLL------------------------------------------------------------------------------------------SDDALLWSWIALAVLVFPVL--FLVSA-----------PYGRH------LRTG-------WGP---TLRSDLGW---I-IQESP--SFLIMAVYLTRWLRQRTDKLLKLGFDE---------------------------------REWMTVTLA---FCWLVHYANR------------AFVFPLRM------------RGGS-KPTTF-TVVSTAIL---FCVINTY-LNAKALF------VYELVI--------------------------------------------------RSRR-------SLDWAFCSGLLLWVCGLIGNWHSDAITRALRRNPE-------------------------------------EIKEK-RYAIPYGGLYRYVSAPNYFSEFVEWTGFAIA-A--------------------------------------------------------QT----------W-AAFSFALWTFSNLYPRARSNHQ------WYLENFA-EYKSLNRNAFF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNPLKSAAVRARAPQRRGASSHQQKSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [292]
'gi|89309274|gb|EAS07262.1| 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Tetrahymena thermophila SB210]'                    ----MLIPPTFDYFG---------------------------------------DT------------------------------------------VSIICLIVVIFYSSFCWIN---KYIPI-----------NYGKQ------LKSF-------FNF---NL-GKMSW---F-FFEVP--NLIIAGWFMTQYT-----------------------------------------------DNLVNYVML---LPFIIHYINR------------SIIYPMTL------------QNNT-KPIPI-EVCLFATS---FTTCNSY-LQAKSIL------SVQES---------------------------------------------------KFSD-------LFKWNVLLGYLIFIFGMYINIKSDRYLQSLKKNLS------------------------------TANSKT--GEKK-NYVIPREGFFVYVSQANYFGEIVEWVGFAILQT--------------------------------------------------------HS----------Q-MPWLFAISTLSILSSRALESHK------WYQQTFK-EYPK-ERKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [266]
'gi|68392311|ref|XP 685982.1| PREDICTED: similar to Srd5a1 protein [Danio rerio]'                                    ----MDALLN-------------------------------------------------TLFSSE--EEELY--------------------------VLDCLSYLMMAMALITFVAL--LFEHV-----------PYGSL------A---------------------------------------------LWSSSSKI-------------------------------------------IHLPNQLLL---LMFVCHYMQR------------SLIYPFLI-------------RGG-KSTPF-ISLVLAFV---FCIYNGY-LQGRYLS------HYA--D-Y------------------------------------------------PADW-------VTHPCFIIGSCMWFLGWIINMHSDHILRNLRKPGE-----------------------------------------T-GYKIPRGGMFEYVSGANFFGEIVEWAGFALA-G--------------------------------------------------------QS----------I-HSAAFALFTLIVLSCRGMDHHK------WYLAKFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [236]
'gi|3881515|emb|CAA92499.1| Hypothetical protein ZK1251.3 [Caenorhabditis elegans] >gi|17544706|ref|NP 501719.1| ZK1251.3 [Caeno'    ----MLYA------------------------------------------------------------------------------------------IIIIGSWLMTTCGIFVFLTLSNTEKPL-----------GYGRY------SDSL-------ATTR--TLPPTISW---M-IQGFP--SFIIPFYLYWTNQH----------------------------------------------LTEYGSFLT---CLMTFHYAYR------------SFVYPFII-------------NSD-NQSPV-KIVIMAFG---FSVLNGF-IQGTWNA------FYQ--P-E------------------------------------------------FDTL-------HPKFFVFLGAWLFVIGFITHCVSDLHLITLRNDYL-----------------------------------------N-SYSIPRGHYFEYISCPNYFGECLQWIGYALA-A--------------------------------------------------------RS----------F-PAIAFAFFIVCNLAPRAMSHHK------WYQKMFGEQYPR-DRHALV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGVW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [253]
'gi|60494432|emb|CAH09228.1| putative membrane dehydrogenase protein [Bacteroides fragilis NCTC 9343] >gi|52217901|dbj|BAD50494.'    ----MSIE------------------------------------------------------------------------------------------SFNLLLLVMGLVALVVFIAL--YFVRA-----------GYGMF------RSRS-------WGI---SVNNKIAW---I-LMEAP--VFLVMGWLWWHSDRR---------------------------------------------FLPVELTFF---LFFQLHYFQR------------AFVFPFLM-------------KGK-SKMPV-LILLMGVI---FNILNGL-MQGEWIF------YLAPSDYY------------------------------------------------TPGW-------LLTPCFWIGTLLFFAGMGINWHSDSVIRHLRAPGD-----------------------------------------T-RHYLPQRGMYRYVTSANYLGEIVEWVGWAIL-T--------------------------------------------------------WS----------L-SGCIFAWWTVANLVPRADAIWH------RYREEFGTQVG--LKKRIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [253]
lcl|3068_Cre_unnamed_protein_product                                    ----------------------------------------------------------------------------------------------------------MIGTAVPVFLALI-AGITA-----------PYGRY------VRSG-------WGI---FLNARVAW---L-TQEIP--SLIVFVVMLFLQHP-----------------------------------------------LSARTVLS---GAFCAHYVYR------------SIVFPFII-------------RGG-KPTPL-SVWAMSFV---FCIWNGF-IQGWCFA------RQM--T--------------------------------------------------SDTP-------VWNPRVMVGLAVWLFGWLNVMRADLILINLRKPGE-----------------------------------------S-GYKIPHGGMFNFVSAGNYASEICEWSGFALA-A--------------------------------------------------------GT----------L-PAAAFAMFAFCNLSPRGHHHHR------WYREKFKGEYPA-SRRAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [237]
'gi|76646706|ref|XP 871267.1| PREDICTED: similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Steroid 5-alpha-reductase 1) (SR ty'    MRSLIPGASQVWALGDRLRTGLSCH-------------------------------------------------------------------------QPLPLALTQGPLPWLRIRKEQKGAMAT-----------VPGRDPSEPLPVSEG-------ACA---GTPSQDPA---L-VLQCR--CLHSPASQCQST------------------------------------------------CTSVSPVLVTGSGCVVITTTQR------------SLVFPFLI-------------RGG-KPMPL-YAFLLAFI---FCTYNGY-LQSRYLS------QYA--V-Y------------------------------------------------ADDW-------LSDPRFLTGSALWLIGMLINIHSDHVLRNLRKPGE-----------------------------------------T-GYKIPRGGLFEYISAANYFGEVVEWCGYALA-S--------------------------------------------------------WS----------I-QGWAFAVFTFCVLFTRAQQHHK------WYHEKFE-DYPK-FRKIMI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [279]
'gi|12083683|ref|NP 073202.1| steroid 5-alpha-reductase 2 [Rattus norvegicus] >gi|401057|sp|P31214|S5A2 RAT 3-oxo-5-alpha-steroi'    ----MQIVCHQV--------------------------------------------------------------------------------------PVLAGSATLATMGTLILC----LGKPA-----------SYGKH------TESV-----SSGVP---FLPARIAW---F-LQELP--SFVVSVGMLAWQPRSL--------------------------------------------FGPPGNVLL---ALFSAHYFHR------------TFIYSLLT-------------R-G-RPFPA-VLFLRATA---FCIGNGL-LQAYYLV------YCA--E-Y------------------------------------------------PEEW-------YTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGE-----------------------------------------V-IYRIPRGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------V-PAFAFAFFTLCFLGMQAFYHHR------FYLKMFK-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|999038|gb|AAB34213.1| steroid 5 alpha-reductase type 2 isoenzyme; SR type 2 [Macaca fascicularis] >gi|2498888|sp|Q28892|S5A2'    ----MQVQCQQS--------------------------------------------------------------------------------------PVLAGSATLVALGALVLY----VAKPS-----------GYGKH------TESL-----KPAAT---RLPARAAW---F-LQELP--SFAVPAGILARQPLSL--------------------------------------------FGPPGTVLL---GLFCVHYFHR------------TFVYSLLN-------------R-G-RPYPA-VLIFRGIA---FCAGNGF-LQSYYLI------YCA--E-Y------------------------------------------------PDGW-------YTDIRFCLGVFLFILGMGVNIHSDYILRQLRKPGE-----------------------------------------I-TYRIPKGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSVCFLGLRAFHHHR------FYLKMFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|39589767|emb|CAE67002.1| Hypothetical protein CBG12401 [Caenorhabditis briggsae]'                                    ----MLYA------------------------------------------------------------------------------------------VIVIGSWLMTTCGIFVFLTLSNTGKPA-----------EYGRY------SNPS-------PSKS--MIPAKLAW---M-TQESP--AFFIPFYFYWTDQH----------------------------------------------LTEYGKFLT---CVFLFYYAYR------------TFAYPLLI-------------RSK-NETPF-EIVLMKFL---FCIFNGF-IQGSWNA------YYQ--P-E------------------------------------------------IDKF-------HPRFFVFFGIWLFVIGFIIHCISDLHLISFRYNLP-----------------------------------------NDTYSIPRGHLFEYISCPNYFGECLQWIGYAIS-T--------------------------------------------------------RS----------F-PAIAFAFFVVCNIAPRAASHHE------CYKKKFGAQYPN-DRMALL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGLW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|401056|sp|P31213|S5A2 HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Steroid 5-alpha-reductase 2) (SR type 2) (5 alpha-SR2)'     ----MQVQCQQS--------------------------------------------------------------------------------------PVLAGSATLVALGALALY----VAKPS-----------GYGKH------TESL-----KPAAT---RLPARAAW---F-LQELP--SFAVPAGILARQPLSL--------------------------------------------FGPPGTVLL---GLFCVHYFHR------------TFVYSLLN-------------R-G-RPYPA-ILILRGTA---FCTGNGV-LQGYYLI------YCA--E-Y------------------------------------------------PDGW-------YTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------I-SYRIPQGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYLKMFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|39812447|ref|NP 000339.2| 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Homo sapiens] >gi|85567678|gb|AAI12253.1| SRD5A2 protein'     ----MQVQCQQS--------------------------------------------------------------------------------------PVLAGSATLVALGALALY----VAKPS-----------GYGKH------TESL-----KPAAT---RLPARAAW---F-LQELP--SFAVPAGILARQPLSL--------------------------------------------FGPPGTVLL---GLFCLHYFHR------------TFVYSLLN-------------R-G-RPYPA-ILILRGTA---FCTGNGV-LQGYYLI------YCA--E-Y------------------------------------------------PDGW-------YTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------I-SYRIPQGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYLKMFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|62175578|gb|AAX69711.1| 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative [Trypanosoma brucei] >gi|70803111|gb|AAZ13015.1'    ----MMISQSHSPFT---------EAGGFAAAVTLLFTAMGMVILSSHLMPLTGTR------------------------------------------VLELSSKIHLTMAAGTFLLLR-FALIA-----------PFGKH------SGLS---------TVRIRVPALLSW---S-LQECP--TLLSIIYYIVVEYPCYVHQCNPLQWLHMILDRPSMEVTTTVAS-----------------AAPTLRLGL---LFFAVHYFNR------------SVLYPLRV------------ANHG-TSVPL-HITLSAML---YCALNGR-LQLLANIDSV-----------------------------------------------------------DASQRLVVDSTWQTILTILGAVIFFAGMLVNVTSDCYLIRLKKRPP----------------------------------------LG-AYKIPYGGLFVFVSCANFFGEIVEWFGYVAV-V--------------------------------------------------------YGTNGTVAG---L-AALSFAAYVVANLLPRAYAHHQ------WYIQHFGAEYTALQRRAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [335]
'gi|15187312|gb|AAB69279.2| steroid 5-alpha-reductase 2 [Sus scrofa] >gi|47522802|ref|NP 999153.1| steroid 5-alpha-reductase 2 ['    ----MPVRCQQS--------------------------------------------------------------------------------------PVLAGSATLAALGALALY----FAEPS-----------GYGKY------TESL-----TPAAI---RLPARAAW---F-LQELP--SFVVPAGILAGQPRSL--------------------------------------------FGPPATVLL---GLFCAHYFHR------------TFVYSLLT-------------R-G-RPFPV-VFLFRGFV---FCMGNGL-LQGYYLV------YCA--E-Y------------------------------------------------PAEW-------YTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------V-IYKIPQGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYVKMFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|74223869|dbj|BAE23830.1| unnamed protein product [Mus musculus] >gi|20178115|sp|Q99N99|S5A2 MOUSE 3-oxo-5-alpha-steroid 4-de'    ----MPIVCHQV--------------------------------------------------------------------------------------PVLAGSATLATMGTLILC----FGKPA-----------SYGKH------SESV-----SSGVP---LLPARIAW---F-LQELP--SFVVSVGMLAWQPRSL--------------------------------------------FGPPGNVLL---GLFSAHYFHR------------TFIYSLLT-------------R-G-RPLSA-VIFLKATA---FCIGNGL-LQAYYLV------YCA--E-Y------------------------------------------------PEEW-------YTDMRFSVGVFFFILGMGINIHSDCMLRQLRKPGE-----------------------------------------V-IYRIPQGGLFTYVSGANFLGEIIEWMGYALA-T--------------------------------------------------------WS----------V-PAFAFAFFTLCFLGMQAFYHHR------FYLKMFK-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
gi|228295|prf||1802385A_steroid_5alpha_reductase_2                                    ----MQVQCQQS--------------------------------------------------------------------------------------PVLAGSATLVALGALALY----VAKPS-----------GYGKH------TESL-----KPAAT---RLPARAAW---F-LQELP--SFAVPAGILARQPLSL--------------------------------------------FGPPGTVLL---GLFCVHYFHR------------TFVYSLLN-------------R-G-RPYPA-ILILRGTA---FCTGNGV-LQGYYLI------YCA--E-Y------------------------------------------------PDGW-------YTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------I-SYRIPQGGLFTKVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYLKMFE-DKPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|71665005|ref|XP 819477.1| 3-oxo-5-alpha-steroid 4-dehydrogenase [Trypanosoma cruzi strain CL Brener] >gi|70884780|gb|EAN9762'    ----MCRKTHIHMLERHGGNLLSTWTWLLVAVVFLLITTICMVLLQQYVLPLGSAT------------------------------------------VIESASYFHLVMAAMTYFTLR-FVEVA-----------PFGRH------VTST---------TAHVTMPAPLSW---A-LQECP--TLMNVVYYLLMEYPCHALRCSSSQWIRLVFDDPFGQAAHAISE-----------------GITSLHVGL---LLFVIHYLHR------------TLLYPLII-------------GEG-APVPI-KITLSAAV---YCLLNGR-LQLLANIRDG-----------------------------------------------------------PSAPRFPLLFTSHMALFWIGIVLFFAGMGVNVLSDNRLVRLKKQPP----------------------------------------RH-TRKIPHGGLFEYVSCANFFGEIVEWCGYSLV-V--------------------------------------------------------WSTAATTKPESGL-AAFSFSVYVMANLLPRGYAHHE------WYKKQFGAAYDKLRRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [346]
'gi|73980711|ref|XP 532922.2| PREDICTED: similar to 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Canis familiaris]'                      ----MPIRCQQS--------------------------------------------------------------------------------------PVLAGSAALAAMGALFLY----LAKPS-----------GYGKY------SEGL-----TPAAP---RLPARAAW---L-LQELP--SFAVPAGILARQPRAL--------------------------------------------LGQPATVLL---GLFCAHYFHR------------TFIYSLLT-------------R-G-RPFPV-VFVVRGFI---FCAGNGL-LQGYYLI------YCA--E-Y------------------------------------------------PAEW-------YMDVRFSLGIFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------V-IYRIPQGGLFTYVSGANFLGEIIEWIGYALA-T--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYLKMFE-DYPK-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|76646522|ref|XP 605410.2| PREDICTED: similar to 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Bos taurus]'                            ----MSVRCQQS--------------------------------------------------------------------------------------PVLAGSATLAALGALVLY----LAEPS-----------GYGKY------SENL-----MPVAI---RLPARAAW---F-LQELP--SFAVPAGILAGQPSSL--------------------------------------------LGPPATVLL---GLFCAHYFHR------------TFVYSLLT-------------R-G-RPFPV-VFLFRGFV---FCMGNGL-LQGYYLV------YCA--E-Y------------------------------------------------PAEW-------YTDIRFSLGIFLFILGMGINIHSDYILRQLRKPGE-----------------------------------------I-IYRIPQGGLFTYVSGANFLGEIIEWIGYALA-S--------------------------------------------------------WS----------L-PALAFAFFSLCFLGLRAFHHHR------FYLKMFD-DYPK-SRRALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [254]
'gi|71656461|ref|XP 816777.1| 3-oxo-5-alpha-steroid 4-dehydrogenase [Trypanosoma cruzi strain CL Brener] >gi|70881928|gb|EAN9492'    ----M--------LKRHGGNLSSTWAWLLVAVVFLLITTVCMVLLQQYVLPLGSTT------------------------------------------VIESASYFHLVMAAMTYFTLR-FVEVA-----------PFGRH------ATST---------TAHVTMPAPLSW---A-LQECP--TLINVVYYLLMEYPCHALKCSSSQWIRLVFDDPFGQAAHAISE-----------------GITSLHVGL---LLFVIHYLHR------------TFLYPLII-------------GEG-APVPI-KITLSAAV---YCLLNGR-LQLLANIRDG-----------------------------------------------------------PSAPRFPLLFTSHMALFWIGIVLFFAGMGVNVLSDNRLVRLKKQPP----------------------------------------RH-SRKIPHGGLFEYVSCANFFGEIVEWCGYSLV-V--------------------------------------------------------WSTTATTKPESGL-AAFSFSVYVMANLLPRGYAHHE------WYKKQFGGAYDTLRRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [338]
'gi|40062892|gb|AAR37763.1| steroid 5-alpha reductase family protein [uncultured bacterium 442]'                                    ----MAWYTGNA--------------------------------------------------------------------------------------LYDTLLLVGFAYALLVFAAS--FVGTA-----------AYGGR---FGLKGKK-------QGI---KLGSRMGW---I-IMELP--GLMVFPVVYFMGTNA---------------------------------------------YEAVPLFFL---AVWMMHYSNR------------ALITPMLMRVQ---------PGTP-ASFSF-NVIIAGWI---TLFLHGY-FNAAYLT------EYG--DQY------------------------------------------------TLDW-------FSDPRFVLGLIVYATGFGLNIHSDHILRNLRSKTP-------------------------------------APNEP-RYKIPFGGAFRWVTCPQYLGEILSFTGFAIM-T--------------------------------------------------------WN----------L-GAVFVLAMTAGNLIPRALYTHR------WFRKNFD-EYPP-ERKAIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [266]
lcl|2792_Cre_unnamed_protein_product                                    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVML---CGWLLHYLYR------------GFITPFIM------------PYSS-RTVAL-GIPLAGIV---PNCIFGY-LVATQLA----------CTRY------------------------------------------------PSDW-------AGRPRYIIGVVLYALGTAINRWADLKLRAGRSSPA---------------------------------------SLS-RYFIPQGGLYDYIACPNYLGELIEWAGFAVG-T--------------------------------------------------------WS----------W-PALSWLLFCTSTFVPRALTHLR------WYRDTFP-EYPR-SRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [178]
'gi|47206213|emb|CAF91080.1| unnamed protein product [Tetraodon nigroviridis]'                                    ----MVTGVFG---------------------------------------------------------------------------------------GCASRWHPGCPLSLQELQRR--ARVRT-----------LAGHR------SSP--------------RGPNRLQK---VQIKDKL--GLVEPL-ISGVVMK-LG-------------------------------------------LGKASRRPV---HPQDSSSLER------------SVIFAALT-------------R-G-RPVPL-PIVLYAAI---FCSLNGF-LQGHHLL------HCT--S-A------------------------------------------------EATG-------PPGARAAAGFLLFLVGMGINIHSDHVLRSLRRPGE-----------------------------------------V-AYRIPRGGVFELVSGANFLGEILEWAGYALA-T--------------------------------------------------------WS----------L-PALAFAFFTACSIGPRAYHHHSGRMITGWRFGLRA-ELPG-PARAWIWCVRRDVDAALAGICTRLRRAERSGGSGADAQVLRQDAGVSVPSTSTITMATWGQPCHNCSAQTGSKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLVLGLQVLLFVFSILRKVAWDYGRLALVTDADSVSTAVHSETQDRYERLTSVSSSVDLEQRDNGFCSWLTAIFRIKDEEIREKCGEDAVHYLSFQRHIIGLLVVIGVLSVGIILPINFSGDLLGETPLRLCSRRRENNAYSFGRTTIANLKSGTNLLWLHTSFAFMYLLLTVYSMRRHTSKMHYKEDDLVGRGDAGMEQGCSSELGAQLPVFQVKRTLFINGVSKYAEESQIKQHFQQAYQNCVVLEARICYNVAKLMALNAERYQQEEEASSSGGASPVFCSPQEEGGAQQEVLHRPDGQGARPHHDQPQALRTPLLLRPGRLRGGGGGELLHQEGGETEGGVQEGEGEGPQQASGHGLRHLPERGHHRPDPEGLQRLPGPGLPVPAGAALVPVQRGSARPALERLLRPRPPERPLVGRRRSSWSRTGLSSSLLLQGTSVLGGRLLVDPLLRHQLHPVPPALLPHHAGHHHLHHGQVQRHQACGVPEQPHRDPVLPDPPALGLLRPAAHHRLLLGFLRGPLDQVWREQDHDAQVLHLPDLHGPAAAVSGTQQVPTCGPRVPAVPPPSPLSLFPCLSSAWTSSSAGSSIRSSWQTGPSDSSTCPTASARPPPSHMTPVWTLVSLRCVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAADRRNVKRHQAYEFQFGAAYAWMMNVFTVVMAYSITCPIIVPFGLMYMLLKHLVDRYNMYYAYLPSKLDKKIHSGAVTQVVAAPILCLFWLLFFSTVRTGFETPTSMFTLVVLIVTIVVCLSHVCFGHFKYLSAHNYKVSLSPRAAAAARLTFCLCSDRHQGHGDGRCDGERMSGPAHLLTRRQTSDVHRSGAPGPKHRGAGRCRRRRRRGGPELAAGGGANERREQHQRGRFPVRGGQSDR   [1263]
lcl|Smo_DET2_10_2_unnamed_protein_product                                    --------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTVPQSFFTHFYVVGVTWNTLLLATATLSSCMCTLSSASDGIQFSALVEQFTGAGASAGSGSIPSMAKQKQ--------RGWTVVLLL---LLMELQVCRR------------LYESLMVL------------SYGPDARMHL-LGYLVGLF---FYVAAPLSLC------------------CQEIGEIMINTLGTVSQGRLRSSCAWNPDTRWWECFHYSPW-------------------RLNWYQWLGALLFLWGWYHQYKCHQILASLSSEEE-------------------------------------SGEGK-TYVIPYGDWFDKVSCAHYLSEIVMYFGLVFA-SG-------------------------------------------------------GT----------QATIWFLLAWVFSNLYLAAKETHE------WYLSKFE-NYPK-NRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [288]
'gi|39943788|ref|XP 361431.1| hypothetical protein MG03905.4 [Magnaporthe grisea 70-15]'                                    ----M------AIIENWIPPTRE---------------------------------------------------------------------------NWETLLFVWKFFPILPSVQWLTPWY-------------PMGKT-----------------SYPSIFNVPGRLAW---F-LMEIP--GVSILLYNMSTLPAKHG--IDD--------------------------------------LPWQNKVLA---GLFAIHYSYR------------AVMYPLMA-------------PSM-APMNI-VVASSAVF---FQVMNGT-CLGAWLA------AYGPTT--------------------------------------------------QEEWRAQL-GAGGTLQFVVGISIFYLGLAANYYHDDELREIRRREE--------------------RRRERVARDEGVRPE---TVER-HYAIPQAGFFKFVLYPHYFLEWCEWFGYWMA-CG-------------------------------------------------------WS----------CTPAFLFLFNEFVSMLPRAVNGRK------WYEERFGPEKIK-GRKAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [291]
'gi|19114263|ref|NP 593351.1| hypothetical protein SPAC9.08c [Schizosaccharomyces pombe 972h-] >gi|6014427|emb|CAB57426.1| SPAC9'    ----M---------------------------------------------------------------------------------------------FYSDYLKLLKIFVVGVFPCT--LFVNA-----------PHGKL------AKQS-------KLFSKGYISGRVGW---V-LMELV--APLTFLYAIRNNRHFESTLPSLGDGSNRDY------------------------------LDSCRKVLA---GMFLVHYANR------------ALVSPLLM------------APQV-SPMHW-TVFVSAVL---FNFLNGM-SIGLYLV------QASVQHHP-----------------------------------------------------------VSIIRRYIGMFLWLMGWLGNMYHDNILYDLRRSSN--------------------------KKKDPDNLDTVQSENS-YYRIPYGGLFQYVSCPNYFCEWIEWFGCYLA-AG-------------------------------------------------------PS----------AEPFWWFFLSEILLMLPRALKAHQ------WYCKKFP-KYPA-NRRAII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [282]
'gi|88179323|gb|EAQ86791.1| hypothetical protein CHGG 08044 [Chaetomium globosum CBS 148.51]'                                    ----MTTTTTTGLIPNWYPPNRP---------------------------------------------------------------------------NYDLILTLWQFFPLAASLQWAHPLI-------------NPERL------------------------------------VEEGG--------------------------------------------------------------LPWQNKLLG---GLFVTHYLYR------------AVVFPFLQ-------------PSM-SPLHV-IIWASGVF---FQVTNGL-AIGGWLA------GYGPAT--------------------------------------------------QAEW----AAATGSWQFVGGVGVFFAGLAANYWHDDALREIRRRAA--------------------RRAASGKKGDGKSA----AVDK-VYEIPQAGLFKVMLYPHYFVEWVEWFGFWMA-AG-------------------------------------------------------WG----------CVPARCFLFNEIAAMLPRAVSGRK------WYVEKFGEEKIR-GRWAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGVW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [258]
'gi|50928145|ref|XP 473600.1| OSJNBa0020J04.7 [Oryza sativa (japonica cultivar-group)] >gi|38345532|emb|CAD41302.2| OSJNBa0020J0'    ----METEGWPALQ------------------------------------------------------------------------------------PLLCLAWIATTLPIIVAALPIPAAAGGHLLRRLLSAFSSRGKT-------VRPSPASSSGSSSSKAKFTVPQKYFMHFYVVGVLATTILLLAIWFYAYMKMTPLLPESSSYSTIASHLVGSNSFSFGRVHSRTMGHKY--------HVWRTVFVL---LLMEIQVLRR------------LYETEHVF------------HYSPSARMHI-VGYLTGLF---YYVAAPLSLA------------------SSCIPEAAEYLQGQVAE-FIVKGRARMPDLVIDSSSLLQPLL------------------KLGWTQWIGAVIFIWGSLHQIRCHAILGTLREHKD----------------------------------------SD-EYVIPCGDWFNRVSCPHYLAELVIYFGMLVA-SG-------------------------------------------------------GE----------DIPVWFLFVFVITNLSFAAVETHK------WYLQKFE-DYPR-SRYAII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [354]
'gnl|CMER|CMD146C similar to 3-oxo-5-alpha-steroid 4-dehydrogenase'                                    ----MSLSIQSRS----------GRELLRLSLREPGAPQTVDDLQQLLWLQGPRVKPLRQRLTLPT----GVASAPKARSLLEAGHKLEEYGIRVDAGAQDFVVHFK---------------------------------------------------------DLGPQVSWRGVF-LAEYLGPLVLFPIVFTLQLGGLDFSYAWHR-------------------------------------ALPQQRAAL---VAWTLHFAKR------------ELETLFVH------------RFSN-ATMPWRNLVKNCAY---YWGFATY--VAYFVCHPRYTPV------------------------------------------------------------------ASHIQFWIGVLCFGIGELGNLVCHWRLRQLRPAGT-----------------------------------------R-LRQIPYGFLFELVSCPNYTFEVLAWVGFNLM-T--------------------------------------------------------QT----------I-AGILFMLVGTLQMMIWAQAKHR------QYLKEFGTLYPR-SRKRMF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [311]
'gi|15237245|ref|NP 197105.1| 3-oxo-5-alpha-steroid 4-dehydrogenase [Arabidopsis thaliana] >gi|9755647|emb|CAC01800.1| steroid 5'    ----MEMVTSFVYPP-----------------------------------------------------------------------------------PPSILLNCMSVVGVAALANIGWSEIRGNHL--------KYSKF--------GVSSSSPQPQKERFGSISSRNGM---L-LLYTP--AFLAAASSFFVVPS----------------------------------------------DDLRFLLLK---SALALHFFKR------------VFEVLFIH------------KYSG--GMAIDSALTISSS---YFSSTALMLYSQNLTLGLTEPSFD--------------------------------------------------------------------MKLAGVVMFVVGIVGNLYHHVLLAKLRKEDG----------------------------------------KK-EYKIPKGGLFDIIICPHYLFEILVFWSFFLI-S--------------------------------------------------------QT----------I-YSFSFAMGTMLYLIGRSYATRT------WYLSKFD-DFPK-HIKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [268]
'gi|68394533|ref|XP 689208.1| PREDICTED: similar to steroid 5 alpha-reductase 2-like [Danio rerio] >gi|55962416|emb|CAI11971.1|'     ----MFHILSIVNII-----------------------------------------------------------------------------------WLLLALCFGAAFCLNKFSVKLPNRVEH-----VFQDFIRYGKT------------KENIKRASWQLVFDLSKRYFYHFYVVSVMWNGLLL----LFSIRSVVMSEAFPDWIIDVLGSLTGRSRGAWNE------------------IHLSTLLLQ---VLLWVHTLRR------------LLECLFVS------------VFSD-GVINV-VQYAFGLS---YYIILGLTVL--------------------------------------------------------------CTNDSLPQSESVSFFNQLTWYHVVGTLLFFWASFLQHQSLSLLAKMRTDSS------------------------------------GKVETL-AHKMPCGGWFELVSCPHYLAELLIYAAMCVC-CG-------------------------------------------------------CA----------SLTWWMVVLYVLCNQALAAQLCHE------YYRSKFK-TYPH-HRKAFI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [309]
'gi|72102897|ref|XP 785169.1| PREDICTED: similar to steroid 5 alpha-reductase 2-like [Strongylocentrotus purpuratus]'                ----MS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTSYPVSPPAV--------------------------------------------------------DLLTVLIAM---AVIVIHAHRR------------IYECLAVS------------VYSN-SSIHV-THYITGIF---FYSFIGISIM------------------AEGPNLSLKGTGEPIQL--------------------MDLVE------------------DLRWHHIAGLLMFVWASWHHHIAHVIFASLRKTKK----------------------------------GKSTHNVS-RHMIPQGDWFDYVSCPHYLAETLIYTSLAVI-LG-------------------------------------------------------GH----------HRTWWLVLSFVFSNQTAASVKVHR------WYQGKFE-DYPK-ERKAFM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [213]
'gi|66826619|ref|XP 646664.1| hypothetical protein DDB0190926 [Dictyostelium discoideum] >gi|60474548|gb|EAL72485.1| hypothetica'    ----MVDIKVVSQ-----------RSKKEVGSFSTSSSTTVGELKKQISSKTR-LGTERIRLAVPS----KTSKLPNAFEALGKDSDLVSKHVG-----ADSTLYFK---------------------------------------------------------DLGPQISWSLVF-ICEYAGPLFVYPIFYFLSNLIYGTDSP----------------------------------------KSFAQKVAL---VCYSLHYIKR------------IYETIFVH------------RFSH-GTMPIFNLFKNCSY---YWGCTAM--VSYFVNHPLYTE-------------------------------------------------------------------APIERVYLGLGLWIIGEVFNYICHIQLRNLRPAGS-----------------------------------------T-ERKIPRGLLFEFVSCPNYTVEILSWIGFSIL-T--------------------------------------------------------QT----------L-TSWIFALMGAAQMWIWAVGKHR------RYRKEFGDKYPK-SRKILI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [300]
'gi|68475536|ref|XP 718116.1| putative steroid 5-alpha-reductase [Candida albicans SC5314] >gi|46439872|gb|EAK99184.1| potential'    ----MTDIEVKSR----------SRSIKSFSSNELTPDSSVQELINELSSDNH-ISEHRLRLTKLE---------NGKQVALIPHKTFAENGIP--KTASKIELFVK---------------------------------------------------------DLGPQISWRTVF-LVEYFGPFIFHPLFYYVQSLYGSGSFE----------------------------------------HTQTQKFAF---AIVLLHFLKR------------ELETIFVH------------KFSN-ATMPAFNIFKNSGH---YWILSGF-NLAYFIYGP--SDKSGVLKYFFHVNE------------------------------------------------------LPSSVVYGLFGLWVFAELSNLTTHLILSNLRKGDS-----------------------------------------K-VYVIPFGYGFNWVSCPNYFFESLSWLAYALL-V--------------------------------------------------------GN----------W-SAWIFLFVSSGQMWLWAVKKHQ------RYLKSFGDDYKKLKRKIYI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [312]
'gi|50261040|gb|EAL23690.1| hypothetical protein CNBA3370 [Cryptococcus neoformans var. neoformans B-3501A]'                         ----M-------------------------------------------------------------------------------------------------------------------------------------GHH-------------------------GARFSY---N-LFDDN------------------------------------------------------------------RKQLS---SFFESSLENTLWAVSRALCPSGYYITPDTF-------------TKK-VAPPY-HCCSCGHVVQSFRCRNGY-LLAVGLA------FYPPK---------------------------------------------------EIGW-----------QFVLGVAGWAIGFFGNVYHDEMLNDLRRPPT--------------------KRIVMSHLPEDDASKL-----E-RYKVPRGGLFEWVSFPNYLCEWLEWTCWSFA-ANPYPFISVPALPYLLRAPEYRNSHTVLSIISNFYWPS-------------------WL----------LAPSWAFVLAEVTSMLPRAMRGHA------WYKEKFGNKYPK-SRKAAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGIL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [258]
'gi|68474999|ref|XP 718385.1| putative steroid 5-alpha-reductase [Candida albicans SC5314] >gi|46440150|gb|EAK99459.1| potential'    ----MTDIEVKSR----------SRSIKSFSSNELTPDSSVQELINELSSDNH-ISEHRLRLTKLE---------NGKQVALIPHKTFAENGIP--KTASKIELFVK---------------------------------------------------------DLGPQISWRTVF-LVEYFGPFIFHPLFYYVQSLYGSGSFE----------------------------------------HTQTQKFAF---AIVLLHFLKR------------ELETIFVH------------KFSN-ATMPAFNIFKNSGH---YWILSGF-NLAYFIYGP--SDKSGVLKYFFHVNE------------------------------------------------------LPSSVVYGLFGLWVFAELSNLTTHLILSNLRKGDS-----------------------------------------K-VYVIPFGYGFNWVSCPNYFFESLSWLAYALL-V--------------------------------------------------------GN----------W-SAWIFLFVSSGQMWLWAVKKHQ------RYLKSFGDDYKKLKRKIYI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFFI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [312]
'gi|54644923|gb|EAL33663.1| GA20623-PA [Drosophila pseudoobscura]'                                    ----IITSLEELIDQYN---------------------------------------------------------------------------------VNLTQLVFCIFITTIVFFGSLMTLVESHLPNSIRQSF-RYGKH------------RHKGEADALVSYLEVPKGWFKHFYIFAFGWSLLAL----YLIVSSIASQSAAPEYALRFLDLVCGGATNRKVQV-----------------DSTTALLGT---VLLTLQCIRR------------FYETNFVQ------------IFSKHSKMNL-SHYAVGYV---HYFGAIVSLL------------------------------------------------------------SNTAGFVRGSQPTEFTPKNLSQIQIIYFLVFMFAWHQQYSSNMILVNLRKDAK-----------------------------------TGAVKTE-QHLLPKGGWFNLLSSPHMFFEVVMYFCLADLFT---------------------------------------------------------P----------VRTWKLVFLWVASNQTINALLTHQ------WYKETFK-DYPK-RRRAIL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [319]
'gi|50543208|ref|XP 499770.1| hypothetical protein [Yarrowia lipolytica] >gi|49645635|emb|CAG83695.1| unnamed protein product [Y'    ----MVNLSLRPR-------PAKAKFKGLPANLEVSPEDTVASVVAKLSAATK-LSKSRIRLTVADEENGGAPGAKKKHIVLKPEHAVGDYLFS-----DSPVVFVK---------------------------------------------------------DLGPQIPWRTVF-ILEYLGPLLAHPIIFFGQKFFYRQSFE----------------------------------------YTFAQKLVF---TLCMLHFLKR------------EIETIYIH------------KFSS-ATMPLFNLFKNSGY---YWFIAGF-NLAFFVYAPASFSSPQAPLWKRFLFSTGFFE-------------------------------------------------RTPLFLNLMAALWLWGETSNFWTHFNLASLRNDGS-----------------------------------------K-DHKIPFGYGFNLVSCPNYFFEVVSWIAIALM-C--------------------------------------------------------GN----------W-SAYVFTAIGFGQMYVWAVQKHR------RYKREFGDRYPR-NRKVMV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [327]
'gi|85079929|ref|XP 956446.1| hypothetical protein [Neurospora crassa N150] >gi|32403964|ref|XP 322595.1| hypothetical protein ['    ----M-TTSTVGLIDNWYPPTRE---------------------------------------------------------------------------NYDLILSLWKWFPVAASLQWGISWY-------------GMGKT-----------------SVTSRLNLPGRIGW---L-TMEAP--GFMTLVYMMRTLPAQHGFTLSD--------------------------------------LPWQNKVLA---GLFVFHYSYR------------ALAFPFLQ-------------PSM-APIHI-AIWLSALS---FQIINGT-LIGAWLA------AYGPTS--------------------------------------------------HAAWDRQLFSSFPTLQFTCGIALFYVGLMANFYHDDELREIRRREN--------------------RRQERLAKQNGQKGQPGKKVGK-HYEIPKAGLFKVMLYPHYFCEWVEWLGFYMA-AG-------------------------------------------------------WG----------CLPARCFLLNEVAAMLPRAVKGKQ------WYMEKFGEEKIS-KKWAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGGCFLGRAVPEDLQRAELHPVLNCRWWGPLLTVAWRGHKPPTNTGNPPTPRNFGSKQTELLALGTGPHQREIIEAALDGHDVFVQAATSFGKSLCFQLPAVIDRGITIVISPLLSLMMNQVEALKASDVDARTLNSNTTLAERDYIYADLATGHPLMRLLYVTPELCSGDHFRRKLKLVYEQHELARIVVDEAHCISEWGHDFRKDFKRLSWFRETFPDVPVMCLTATANEQVRHDVLTTLGLDKTPGKLKIFSMTAHRPNLHLEVRFTSDEANDRYDDFVTWLKGVYDRRAAVDRKAELDAIGERVENVPGIIYTISRDEVESLAAALRHDGIGARPFHAKLPNQVKEETLAKWIANDPGYDVIVATTAFGMGIDKENVRFVVHWRLPKSFEGYYQEAGRAGRDGNASYCFLYYSREDRDRVCNLVMREPVSKNASADGIINKQARQMSLSRLVAYCEDTGCCRHAAICRYFGETQVPACDYACDWHKDPQGLKRRMARGLASEEWVSTQREEGMYDEYWSE--------------------------------------------------------------------------   [822]
'gi|28881175|emb|CAD70357.1| conserved hypothetical protein [Neurospora crassa] >gi|25465807|pir||T51905 hypothetical protein B2'    ----M-TTSTVGLIDNWYPPTRE---------------------------------------------------------------------------NYDLILSLWKWFPVAASLQWGISWY-------------GMGKT-----------------SVTSRLNLPGRIGW---L-TMEAP--GFMTLVYMMRTLPAQHGFTLSD--------------------------------------LPWQNKVLA---GLFVFHYSYR------------ALAFPFLQ-------------PSM-APIHI-AIWLSALS---FQIINGT-LIGAWLA------AYGPTS--------------------------------------------------HAAWDRQLFSSFPTLQFTCGIALFYVGLMANFYHDDELREIRRREN--------------------RRQERLAKQNGQKGQPGKKVGK-HYEIPKAGLFKVMLYPHYFCEWVEWLGFYMA-AG-------------------------------------------------------WG----------CLPARCFLLNEVAAMLPRAVKGKQ------WYMEKFGEEKIS-KKWAVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGGW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [302]
'gi|50937343|ref|XP 478199.1| putative 3-oxo-5-alpha-steroid 4-dehydrogenase [Oryza sativa (japonica cultivar-group)] >gi|343933'    ----MESEGWPALQ------------------------------------------------------------------------------------PLLCFAWIAATLPIIAAALPIPTAVGGHLLRRLLSAFSSRGKT-------VRPSPASSSGSSSSKAKFTVPQKYFMHFYVVGVLATTILLLAIWFYAYMKLTPLLLESSSYSTIFSHLVGSNSFSFGRVRSRTMGHKY--------RVWRTVFAL---LLMEVQVLRR------------LYETEHVF------------HYSP-ARMHI-VGYLTGLF---YYVAAPLSLA------------------SSCIPEAAEYFQGQVPE-FVVKGRARMPDLVIDSSSLLQPLL------------------KLGWTQWIGAVIFIWGSLHQIRCHAILGSLREHKD----------------------------------------YD-EYVIPCGDCFNRVSCPHYLAELVIYFGMLVA-SG-------------------------------------------------------AE----------DIPVWFLFIFVITNLSFAAVETYN------WYLQKFE-DYPR-SRYAII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [353]
'gi|15218532|ref|NP 177403.1| 3-oxo-5-alpha-steroid 4-dehydrogenase [Arabidopsis thaliana] >gi|12323774|gb|AAG51854.1| unknown p'    ----MEVEIVWLVK------------------------------------------------------------------------------------AAWITVWIVSILPLVIASIP---SSKLNSFRELVLSFAGRGKI-----------------LHPSSQKFTVPQKFFGHFYVVGVVWTTLLLAATWMYACKMAGGSHVFSFHMTHVEHRF----------------------------KVGRAVFLL---LLMEIHVLRR------------VIESFYVF------------KYSTSARMHI-LAYVGALF---YYVAAPLSLC------------------SNIAPEVARFVGSQVAE-FIASGKSHSHDFNLLLS--ISPLM------------------KLGSLQWIGGAIFLWGWIHQRRCHAILGSLREYPS---------------------------------------QAK-EYIIPYGDWFEMVSCPHFLAEIVLYLGLLIS-SG-------------------------------------------------------GT----------DISIWLLFGFVAANLTYAAGETHR------WYLQKFE-NYPA-SRHAIF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [320]
lcl|Smo_DET2_3_1_unnamed_protein_product                                    ----MALLFFEEY-------------------------------------------------------------------------------------AANSYLYAVLVIGLASLLPMGLLELKGGGL--------RYSKF---------------AEGKSPLGEIPSRIAM---F-LFYFP--SAALAGAVLSATMGILPSPVPEFLKNAH--------------------------------PSPRFLVLT---AAICIHFSKR---------------VLFVH------------KYSG--NAELLSSLSIVFF---YTASTANLLYAQRVAEDLAPPKID--------------------------------------------------------------------LMFLGCVFFVVGIVGNFYHHDLLAQLRSGRS--------------------------------------PQQP-RYVVPHGGLFDLVACPHYLFEIIDFIGLGMI-S--------------------------------------------------------QT----------A-ISAATVMLVAFYLTSRSISTRR------WYLKKVD-GFPR-ERKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [272]
lcl|Smo_DET2_4_2_unnamed_protein_product                                    ----MALLFFEEY-------------------------------------------------------------------------------------AANSYLYAVLVIGLASLLPMGLLELKGGGL--------RYSKF---------------AEGKSPLGEIPSRIAM---F-LFYFP--SAALAGAVLSATMGILPSLAPEFLKNTH--------------------------------PSPRFLVLT---AAICIHFSKR---------------VLFVH------------KYSG--NAELLSSLSIVFF---YTASTANLLYAQQVAEDLAPPKID--------------------------------------------------------------------LMFLGCVFFVVGIVGNFYHHDLLAQLRSGRS--------------------------------------PQQP-RYVVPHGGLFDLVACPHYLFEIIDFIGLGMI-S--------------------------------------------------------QT----------A-ISAATVMLVAFYLTSRSISTRR------WYLKKVD-GFPR-QRKALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [272]
'gi|21552989|gb|AAM62414.1| steroid 5alpha-reductase [Ustilago maydis] >gi|71019863|ref|XP 760162.1| hypothetical protein UM0401'    ----MSILTWIKDVI---------------------------------------GLGTLPSPPYS---------------------------------PAQLYSIVLASFKAWPFLIPVLSLINA-----------PHGRF------AFDS-----------LLNINGNLGW---F-IMEIP--SPIFVLLGALSKPLSASVVKGSGEIFPPLSELFSPSIKHFLA------------------LPSANQVLV---VMFLIHYSHR------------AVLQPLRS-------------PKR-SPLHI-SVPLSAVA---FNLINGF-VMGSWLGGRT---PWSALPQPAVASAALAAVSAKAGN-TASALAASELTRKLISTGAADAVGIDAPGLISNSV-------WKSPLWYLGLAGWAIGFAGNVMHDEILMNIRKPNK--------------------QAQSFQKRFDDKTSVC--KGTS-KYSIPRGGMFEYISFPNYLCEWFEWLSFAFA-AIHSLPIFTHLSIKDAIATA-------------------------------------LS----------T-PPCLFPFVLICLMAPRATNGHK------WYKRTFGDKFPR-ERKAII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [388]
'gi|4160343|emb|CAA22811.1| SPBC646.07c [Schizosaccharomyces pombe] >gi|19112157|ref|NP 595365.1| steroid dehydrogenase [Schizos'    ----MSITLSSRG----------RKIRKLPKSLEFPLDGSIDKLRDEVSSVTR-LPVERLRFSTAD------------GTTLLPNTTLRKYGVG-----PGATIWVK---------------------------------------------------------DLGPQIGWRTVF-MIEYLGPLVIHLFFILNYKWIYRKDYN----------------------------------------LCLNQKIAF---VLVMLHFMKR------------EYESIFVH------------RFSL-ATMPLRNIFKNCAH---YHLLSGL-FLAYFIYGPWHANDYI----------------------------------------------------------------KPNHLLFLIVG-WAFAVLSNFRTHIILRDLRPAGS-----------------------------------------K-KRVIPTGYGFNLVSFPNYFFESLGWLFFALL-T--------------------------------------------------------KS----------W-ASWIFLFVGSAQMFVWAKKKHA------RYLKEFP-NYPR-SRKIMI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [295]
'gi|71019077|ref|XP 759769.1| hypothetical protein UM03622.1 [Ustilago maydis 521] >gi|46099292|gb|EAK84525.1| hypothetical prot'    ----MAFTITIEKRSAPGKP---ASKGFPLTVSLSSQKATLAELKKQIASSSRKLTVERQRITTQD-----------RKPLLDDDKSLVDLGIS-----AGQTLYVK---------------------------------------------------------DLGPQIAWRTVF-LTEYAGPILIHPLFYYFGPQIWKRDFV----------------------------------------PSKMQTVAV---SLAVAHYVKR------------ELETLFVH------------RFSN-GTMPLFNIFKNSTH---YWFLSGF-LLAPFVYSPWFSAASVAGTIQ-----------------------------------------------------------DNTTFIYSTAAVMVLAELANGYTHIILKNLRPAGT-----------------------------------------K-VRKIPRGFGFELVSCPNYFFEFLAWAAFTVL-T--------------------------------------------------------LN----------P-ASALFAAVSTAQMWVWAVKKHK------NYKKEFGKEYPK--RKAMF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [310]
'gi|47219339|emb|CAG10968.1| unnamed protein product [Tetraodon nigroviridis]'                                    ----MNWNFVEWRFIDAL--------------------------------------------------------------------------------WAFLALCFLGALCFHKVLPHLCGMYESCRLVVIFQDLIRYGKT------------KK-LKRESWLVVFDVPKRWFWHFYAISAGWNGILL----FFYGNSIIYHQSYPPWLTGLLDILTGAPSIYSQV------------------PQLSTLLML---MLLCIHSLRR------------LLECLFVS------------VFSN-GVIHL-AQYMFGLC---YYIILGLTVL--------------------------------------------------------------CM-DRLGAATG-NLPSQLEWFHVVGGVLFFGASLLQHQSMVQLAKLRTGQS------------------------------------GKVVSM-AHRVPVGGCFELVSCPHYFGELLIYVSLGLV-VG-------------------------------------------------------GR----------SQTWWLVVLYVFFNQALAAQLCHE------LYNSRFK-SYPR-HRKAFI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [314]
'gi|68125820|emb|CAJ03848.1| 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein [Leishmania major]'                                  ----MSADARIAIIAVVHLALTWVLLRYIADSAMPFYVYREDSSSAGAAHGASVHTAATHEWDLWPPFLVPSQEAYVAQLARQQRATSAADAVALNSRVVWRSSAFHLTLAIFTYALLR-FGVTA-----------PYGRH------SWSL---------GFQLTLPSRVSW---M-LQESP--TIFQVLYHAFLEYPRLMGHSPSQPSLWPASSSASGPTGAGMPSSHSSADTCHSYWGCVRVACTQQHLGL---LLFVIHYVHR------------SWLYPLSI------------PATA-RDVPL-VVTGMATL---YCLFNGR-LQVLASA------GAAATACAADTAARSSACTPAYTASMNLVRCWRERHALQSLSSPSSASTSVGAAAVRVGWWLLLG--LYALGVLGGSALFFLGQRINMQADYYLVRLRRGDKGSISHGGIKPVGRRAVNVHGDALASSSSSEASRAAQHRSSVD-GYRIPVGGWFDSVSCANFFGELVEWTGYVIV-VAATSAASNGSCLSVTTALEEELLRPLSSSSWWSLMNPIMWLRLVARVFFSGSESRPAA----------L-AAFSFLVYVFSNLAPRAVAHHA------WYARTFGDLYTRLGRQALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [543]
'gi|50411010|ref|XP 457010.1| hypothetical protein DEHA0B00990g [Debaryomyces hansenii CBS767] >gi|49652675|emb|CAG84995.1| unna'    ----MVSIEIVPR----------SKGLKSLSTDELEVDSTVEQLLILISKTQN-ISKDRIRLTMKD--------AAGKQVPLDANKTFGGNGIS--KSTNSLTLYTK---------------------------------------------------------DLGPQIAWRTVF-IIEYFGPLLVHPLFYLFSSIYGQGSFT----------------------------------------HTHTQFVAY---VLVLLHFLKR------------EYETVFVH------------KFSN-ATMPVFNILKNSSH---YWILSGF-NLSFFIYGPPTDGSSSLRKFLFHVND------------------------------------------------------FPAYVNYMLAGLWLFAELSNFATHLNLASLRSSSN----------------------------------------TR-NYVIPYGYGFDWVSCPNYFFESLSWLFYALL-V--------------------------------------------------------GN----------W-SSWVFLAVATGQMWLWAVKKHK------RYLKTFGDDYKKLKRNVYV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------   [316]
;
END;


BEGIN CODONS;
	CODESET  * UNTITLED = Universal: all ;
END;


BEGIN ASSUMPTIONS;
	OPTIONS  DEFTYPE=unord PolyTcount=MINSTEPS ;
	EXSET * UNTITLED  =  1-309 318-320 328-413 420 443-486 518 520-571 589 611-617 625 629-631 637-1648;
END;


BEGIN MacClade;
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	LastModified -1035189876;
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END;