#NEXUS [MacClade 4.08 registered to Tomoaki Nishiyama, National Institute for Basic Biology] BEGIN DATA; DIMENSIONS NTAX=89 NCHAR=1512; FORMAT DATATYPE=PROTEIN SYMBOLS = " 1 2 3 4" MISSING=? GAP=- ; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 1510] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] 'gi|15241959|ref|NP 195902.1| RHL2 (ROOT HAIRLESS 2); ATP binding / DNA binding / DNA topoisomerase (ATP-hydrolyzing) [Arabidops' MADKKKRKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKDDEAEELP---------------------------------------------------------------FKSILESDDVITELLKSYISSSIKAAAGAGGASSSSS--------KPLTLADLSLSSSCREVA-DLSL---------------------SSVQTEIETVIVQIARSILA-------------------------------GDGFSF-------SVPSRA-ASNQLYVPELDRI------------VLKDKST-LRPFA---SVSSVRKT---------------------TITTRILALI-HQLCLRNIHVTK-------------RDLFYTD-----------------VKLF------QDQTQSDAVLDDVSCMLGCTRSS-LNVIA----AEKG-VVVGR-LIF-SDNG-----DMI------DCTK-MGMGGKAIPPNI--DR--VGD----------------------M---QSDAMFILLVEKDAAYMRLAEDRFYNR--F-P-CIIVT-----------------AKG-------------------QPD-----VATRLFLRKMKMEL--KLPVLALVDSDPYGL-KILSVY-GCGSKNMSYDS-----ANLTTP---DIKWLGIRPSDLDKYKIP------------------------------------------------------------------EQCRLPMT----------EQDIKTGKDMLEE--------DFV-KKN-PGWVEELNLM------------VKTKQKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLSE---------------VYLPLKLQQQDWL----------------------------------------------------- [427] lcl|Ppa_RHL2_284_1_unnamed_protein_product MQRKR-WNGDNKTKLCRN----------------LKCKSVYSRKTK-----------------------------ET--------SRDPETLCCSKDFPT----------------------------------------------------------------------------------TWSLSVSSVSIKPHQTLQMMNDVTGSGAAVASRSFPHASPCWYPKATDLAISCNYSSAVFAYISSILGRSVDHGRVHKPSTTYKLSSFLPEGMS-------------------DKRKAVREEEVDD-------------------------------------------------------------------------------DILGMSSDG---------------------------------------------------------------------------------------------------------------------------------------PRKQTQAALA---------------------------------------------------------------FKKKLKSDPDILKIVTKF----------AEAAKEADV--------ETRTLADLNLANSCKEVV-ELNT---------------------RSVVLEVEKSILAIAKSILS-------------------------------GNGFGY-------LIPSRS-SANQLYVPELDRI------------VLKDKAS-FRQFA---NIASVRKT---------------------AITTRILQLV-HQLCTKQIHVTK-------------RDLFYTD-----------------VKLF------QEQGQSDTILDDVSCMLGCTRSS-LNVVA----SEKG-VVVGR-LIF-IEDG-----DRI------DCTK-MGVGGKAIPPNI--DK--VQG----------------------M---ESDALFILLVEKDAAFMRLAEDRFYNR--F-P-CVILT-----------------AKG-------------------QPD-----VATRLFLKKMKTDL--KLPVLGLVDSDPYGL-KILSVY-MSGSKNMSYDS-----SNLTTP---DIKWLGVRPSDLNKYKIP------------------------------------------------------------------EQCRLPMS----------DQDIKTGKDMLEE--------DFI-KKD-KNWVKELELM------------VKTKEKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLSE---------------VYLPLKLQQEDWI----------------------------------------------------- [570] lcl|Smo_RHL2_12_2_unnamed_protein_product MKSRR--DKDEAASLCKAAAWAWHLHGGGAAARVLSAKTIEERRTW-----------------------------HTKPSRFLAESRRRQQAPVIDDHPMIIPKQ----------------------------------------------------------------SFTPRAPYLLKWDCGSLLFDSYELVALST-QLDRDLTGVSPTACSLK---ARETHAIQEVQGEIDCDCQHEEIGF-QDAQDEGEDNDGDEEIASCGKAMGCLPLFVQGRR----------------RARKLIRKREAPDLGFLSENGHLREASRAKALAMADAWSIRRVYLALYNCILCAGWASVLVRALAALNGAGYSAVYDSIELPLQLSQTAAILEILVSRVDNQQPRWDCALARQCNSASDLFTPLRYVGCSLEFPRGSKILQAPTRSHWLVTLLVLSWSVTEVIRYSFFAAKEAFGLTPGFLHWLRYSTFFVLYPTGISGEVGLTMLALSHMK------------------------SSKKYSIEMPNAFNFAFSYYYTSLLVLLLYVPGVPFLYTYMIGQRKKSLARTSKKGFSMAPRRGGDGGNAGGELPKRLKTDGAILQTIKDF----------AEATARAGIR------GEKRSLSDLALEESCREVA-ELGS---------------------GEVKEEIEKLVLSVTKSILQ-------------------------------GQGLAY-------TVPSRT-SANQLYVEELDRI------------VLKDKTS-IRPFA---SSSTVKKT---------------------AITTRILELV-HQLCSKQIHVTK-------------RDLFYTD-----------------VKLF------TEQAQSDTVLDDVSCMLGCTRTS-LNVVA----SEKG-VVVGR-LVF-VEDG-----DRI------DCTK-MGVGGKAIPPNI--DK--IQD----------------------M---ESDALFILLVEKDAAFMRLAEDRFYNR--F-P-CVIVT-----------------AKG-------------------QPD-----VATRLFLRKMKMEL--RLPVLGLVDSDPYGL-KILSVY-MSGSKNMSYDS-----ASLTTP---DIKWLGVRPSDLDKYRIP------------------------------------------------------------------QQCRLPMS----------ELDVKTGRDLLEE--------DFI-KKD-PRWYQELELM------------VKNKEKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLSE---------------VYLPMKLQERDWI----------------------------------------------------- [864] lcl|Smo_RHL2_17_2_unnamed_protein_product MKSRRDRDKDEAASLCKAAAWAWHLHGGGAAASVLSAKTIEERRTW-----------------------------HTKASRFLAESRRRQQAPVIDDHPMIIPKQ----------------------------------------------------------------RFTPRAPYLLKWDCGSLLFDSYELVALST-QLDRDLSPPSPTACSLK---AREAHAIQEVPGEIGCDCQHEEIGF-QDAQDEGEDNDGDEEIASCGKAMGCLPLGEGEVASCRELRINRYGWCRVCRARKLIRKLEAPDLGFLRENGHLREASRAKALAMADAWSIRRVYLALYNCILCAGWASVLVRALAALNGSGYSAVYDSIELPLQLSQTAAILEMLVSRVDNQQPR--------------------------------------------------CWSVTEVIRYSFFAAKEAFGLTPGFLHWLRYSTFFVLYPTGISGEVGLTMLALSHMKSVKNPVLEEAKSGFDPIDDLWLSQSSKKYSIEMPNAFNFAFSYYYTSLLVLLLYVPGVPFLYTYMIGQRKKSLARTSKKGFSMAPRRGGDGGNPGGELRKRLKTDGSILQIIKDF----------AEATARAGIR------GEKRSLSDLALEESCREVA-ELGS---------------------GEVKEEIEKLVLSVTKSILQ-------------------------------GQGLAY-------TVPSRT-SANQLYVEELDRI------------VLKDKTS-IRPFA---SSSTVKKT---------------------AITTRILELV-HQLCSKQIHVTK-------------RDLFYTD-----------------VKLF------TEQAQSDTVLDDVSCMLGCTRTS-LNVVA----SEKG-VVVGR-LVF-VEDG-----DRI------DCTK-MGVGGKAIPPNI--DK--IQD----------------------M---ESDALFILLVEKDAAFMRLAEDRFYNR--F-P-CVIVT-----------------AKG-------------------QPD-----VATRLFLRKMKMEL--RLPVLGLVDSDPYGL-KILSVY-MSGSKNMSYDS-----ASLTTP---DIKWLGVRPSDLDKYRIP------------------------------------------------------------------QQCRLPMS----------ELDVKTGRDLLEE--------DFI-KKD-PRWYQELELM------------VKNKEKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLSE---------------VYLPMKLQERDWI----------------------------------------------------- [856] 'gi|50920579|ref|XP 470650.1| Hypothetical protein [Oryza sativa (japonica cultivar-group)] >gi|27476077|gb|AAO17008.1| Hypothet' MAAAAALNRLLPLVLIAAVVGRHGASGDGGFPIVFTETKCTPAPTWSRANDSAYRANVRALLGGLPSAAAPTGFASTDRSGGAGRDRAFARGICFGDPPPALSPQYCLRCLSVAAKELADGCPAKRRAAVWTDGCFASFADTSALSPDEAAFHYKIAVGALVEDDESSARFTATLAALAERLAPRAAANASRMLATATVDVPRVVAGSSRTVQVHS-------------------------------------------------------------------------------------LAQCMPDRPAASCARCVQESARELGKCCWNMQSGGVATVIGYNCHLRLDVSVPMTPSVAEPQSIPAPTVSVRTTGGHVRGNVAAVKA------------------------------------------------------------------AQIVPTQCTDGLRSFGSPHHFTNLSGPLTTGTILLFRTLPNHAAATRAQTLVEFSTSAPPPSPPLKAPKPKSPRFPHAPASKSLDMS-------------------------------EKKRRGGAGAGAASGSASKKPRVSTAASYAESLRSKLRPDASILATLRSLASACSKSKPAGSSSSSSSA--------SKALAAEDDPAASYIVVA-DQDS---------------------ASVTSRINRLVLAAARSILS-------------------------------GRGFSF-------AVPSRA-ASNQVYLPDLDRI------------VLVRRES-ARPFA---NVATARKA---------------------TITARVLSLV-HAVLRRGIHVTK-------------RDLFYTD-----------------VKLF------GDQAQSDAVLDDVSCMLGCTRSS-LHVVA----SEKG-VVVGR-LTF-ADDG-----DRI------DCTR-MGVGGKAIPPNI--DR--VSG----------------------I---ESDALFILLVEKDAAFMRLAEDRFYNR--F-P-CIILT-----------------AKG-------------------QPD-----VATRLFLRRLKVEL--KLPVLALVDSDPYGL-KILSVY-MCGSKNMSYDS-----ANLTTP---DIKWLGVRPSDLDKYRVP------------------------------------------------------------------EQCRLPMT----------DHDIKVGKELLEE--------DFV-KQN-EGWVKELETM------------LRTRQKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLTE---------------VYLPLKLQQQDWI----------------------------------------------------- [830] 'gi|53127616|emb|CAD79468.1| Topoisomerase VI subunit A [Oryza sativa (indica cultivar-group)]' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-------------------------------EKKRRGGAGAGAASGSASKKPRVSTAASYAESLRSKLRPDASILATLRSLASACSKSKPAGSSSSSSSA--------SKALAAEDDPAASYIVVA-DQDS---------------------ASVTSSINRLVLAAARSILS-------------------------------GRGFSF-------AVPSRA-ASNQVYLPDLNRI------------VLVRRES-ARPFA---NVATARKA---------------------TITARVLFLV-HAVLRRGIHVTK-------------RDLFYTD-----------------VKLF------GDQAQSDAVLDDVSCMLGCTRSS-LHVVA----SEKG-VVVGR-LTF-ADDG-----DRI------DCTR-MGVGGKAIPPNI--DR--VSG----------------------I---ESDALFILLVEKDAAFMRLAEDRFYNR--F-P-CIILT-----------------AKG-------------------QPD-----VATRLFLRRLKVEL--KLPVLALVDSDPYGL-KILSVY-MCGSKNMSYDS-----ANLTTP---DIKWPGVRPSDLDKYRVP------------------------------------------------------------------EQCRLPMT----------DHDIKVGKELLEE--------DFV-KQN-EGWVKELETM------------LRTRQKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLTE---------------VYLPLKLQQQDWI----------------------------------------------------- [442] lcl|394_Cre_unnamed_protein_product MSKRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GADDKALALA---------------------------------------------------------------KGKRIRGAEDVLKKVQAL----------ATQLKNSKE--------VEKTLAELDLPYNCREVV-DKDG---------------------DDVMGEIEAAMYNVAASILG-------------------------------GEGFAF-------DVPSRA-KGNQMYVPELDRI------------VLRDAVS-KRPFA---STATCRKA---------------------AVTTRILGLV-HELLGKNIHVTK-------------RDLFYTD-----------------VKLF------EDQSQSDAILDDLACMLGCTRSS-LNVVA----SEKG-VVVGR-LSF-REDG-----DFI------DCQR-MGVGGKAIPPNI--DK--VSD----------------------I---SSDASFILLVEKDAAFMRLAEDRFYNT--Y-P-CIILT-----------------AKG-------------------QPD-----VATRLFLKKLKSSL--KIPVLALVDSDPYGL-KILSVFVLSGSMNMSYDS-----SNLTTP---DIKWLGVRPSDLDRFDIP------------------------------------------------------------------QQCRLPMT----------EEDIKTGKRLLEE--------DWI-KSN-PEWVRELELM------------LASKVKAEIQALSS-----------------------------------------------------------------------------------FGFQ--YLSQ---------------VYLPLKLQEGDWI----------------------------------------------------- [414] gnl|CMER|CMQ111C_DNA_topoisomerase_VI_subunit_A MVAKRKKTATEPRLSTASRKW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQAAESGAVS---------------------------------------------------------------SGTAAVDAESFLNRVREL----------KREIESREAA----KQRFILQQSSDASSAARIEVR-ELDC---------------------DQVLAELERVILSAAKSILE-------------------------------GRGLSY-------KVPRRS-AGNQEYVEELERI------------VLKDGVA-IRNFA---SVASVRKT---------------------TIMTRVLQLV-HELCTRRIHTTK-------------RDLFYTD-----------------VKLF------RQQTESDDVLNDVACLIGCTRNS-LNVVA----SEKG-IVVGR-VTF-QEDG-----DLI------DCTR-MGVGGKAIPPYT--DR--ITN----------------------I---TSDAEFILLVEKDAAFMRLAEDRFYNR--V-K-CIIVT-----------------AKG-------------------QPD-----VGTRLFLRRLKREL--HLPILGLVDSDPYGL-KILSVY-MSGSKGMSYDS-----ANLATP---DIKWLGIRPTDLDRYGIP------------------------------------------------------------------EQCRLAMT----------ENDLKTGKDMLEE--------DFI-KKN-PAWHRELSLM------------VKRKEKAEIQALSN-----------------------------------------------------------------------------------FGFQ--YLTE---------------VYLPEKIRHGDWI----------------------------------------------------- [433] 'gi|62646452|ref|XP 345477.2| PREDICTED: similar to SPO11 [Rattus norvegicus]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALAPMGPEASFFDALDRHRAS----LLAMVKKGAG---ETPDRATR-VPSRYSSQQATESRGRFLMALRRALSEVLTSIENIIQDIIKSLAR-------------------------------NEAPAF-------TIDNRSSWENMTFEDAFGL-------------QMRPQCT-TRKIK-SDSLRSVRKF---------------------ALILKILSMI-YKLIQSNTYATK-------------RDIYYTE-----------------SQLF------RNQAAVDSIIDDISCMLKVPRRS-LHVIS----TSKG-LIAGN-LRYVEEDG-----TQV------QCMC--SATATAVPSNI--QG--MQN----------------------L---VTDAKFLLIVEKDATFQRLLDDNFCSR--MSP-CIMVT-----------------GKG-------------------TPD-----LNTRLLVKKLWDTF--HIPVFTLVDADPYGI-EIMCIY-KYGSMSMSFEA-----HNLTVP---TIRWLGLLPSDIKRLNIP------------------------------------------------------------------KDSLIPLT----------RRDQMKLDSILRR--------PYI-TYH-PFWKKEMEML------------ADSKTKAEIQALSF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLRFGGWI----------------------------------------------------- [417] 'gi|73992352|ref|XP 853487.1| PREDICTED: similar to meiotic recombination protein SPO11 isoform a isoform 1 [Canis familiaris]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFAVLDQHRAS----LLAALRRGGG---EPAGGGTP-QASS---------------------SEVLASIESVIQDIITSVAR-------------------------------NEAPAF-------TIGNRSSWENIKFEDSVGL-------------QMVTHFT-TRKIK-SDSLKSVKKF---------------------ALILKILSKI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVPRMS-LHILS----TSKG-LIAGN-LRYIEEDG-----TRV------HCTC--GATAVAVPSNI--QG--IRN----------------------L---ITDAKFLLIVEKDATFQRLLDDNFCNR--MSP-CIMIT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFALVDADPHGI-EIMCIY-KYGSMAMSFEA-----HNLTVP---AIRWLGLLPSDIKRLNIP------------------------------------------------------------------RDTLIPLT----------KRDQMKLDSVLKR--------PYV-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [396] 'gi|6755624|ref|NP 036176.1| sporulation protein, meiosis-specific, SPO11 homolog [Mus musculus] >gi|9367101|gb|AAF87096.1| SPO1' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDALDRHRAS----LLAMVKRGAG---ETPAGATR-VASS---------------------SEVLTAIENIIQDIIKSLAR-------------------------------NEVPAF-------TIDNRSSWENIMFDDSVGL-------------RMIPQCT-TRKIR-SDSPKSVKKF---------------------ALILKVLSMI-YKLIQSDTYATK-------------RDIYYTD-----------------SQLF------GNQAAVDSAIDDISCMLKVPRRS-LHVLS----TSKG-LIAGN-LRYMEEDG-----TRV------QCTC--SATATAVPTNI--QG--MQH----------------------L---ITDAKFLLIVEKDATFQRLLDDNFCSR--MSP-CIMVT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFTLVDADPYGI-EIMCIY-KYGSMSMSFEA-----HNLTIP---TIRWLGLLPSDIQRLNIP------------------------------------------------------------------KDSLIPLT----------KHDQMKLDSILKR--------PYI-TYQ-PLWKKELEMM------------ADSKMKAEIQALTL-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLRFGGWI----------------------------------------------------- [396] 'gi|56204503|emb|CAI21521.1| SPO11 [Homo sapiens] >gi|61354156|gb|AAX44047.1| SPO11 meiotic protein covalently bound to DSB-like' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDVLDRHRES----LLAALRRGGR---EPPTGGSR-LASS---------------------SEVLASIENIIQDIITSLAR-------------------------------NEAPAF-------TIDNRSSWENIKFEDSVGL-------------QMVSHCT-TRKIK-SDSPKSAQKF---------------------SLILKILSMI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVSRRS-LHILS----TSKG-LIAGN-LRYIEEDG-----TKV------NCTC--GATAVAVPSNI--QG--IRN----------------------L---VTDAKFVLIVEKDATFQRLLDDNFCNK--LSP-CIMIT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HVPVFTLVDADPHGI-EIMCIY-KYGSMSMSFEA-----HHLTVP---AIRWLGLLPSDLKRLNVP------------------------------------------------------------------KDSLIPLT----------KRDQMKLDSILRR--------PYV-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [396] 'gi|76612963|ref|XP 872833.1| PREDICTED: similar to meiotic recombination protein SPO11 isoform a isoform 2 [Bos taurus]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFTPRGPEASFFEVLDRHRAS----LLAALRRGGE---EPAGGGMR-LASS---------------------SEVLSSIEKIIQDIVTSLAR-------------------------------NEAPAF-------TIDNRSSWENIKFEDSVGL-------------HMVSHCT-TRKIK-SDSPKSVKNF---------------------ALILKIFSMI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVPRRS-LHILS----TSKG-LIAGD-LKYLEEDG-----TKV------NCT---RATAVAVPSNI--QG--IQN----------------------L---ITDAKFLLIVEKDATFQRLLDDNFCNK--MSP-CIMVT-----------------GKG-------------------VPD-----VNTRLLIKKLWDTF--HIPVFTLVDADPHGI-EIMCIY-KYGSMAMSFEA-----HNLTVP---AIRWLGLLPSDIKRLNIP------------------------------------------------------------------KGTLIPLT----------KRDQMKLDSILKR--------PYI-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [395] 'gi|21706947|gb|AAH33591.1| Meiotic recombination protein SPO11, isoform b [Homo sapiens] >gi|56204504|emb|CAI21522.1| SPO11 [Ho' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDVLDRHRES----LLAALRRGGR---EPPTGGSR-LAS-------------------------------------------------------------------------------------------------RFEDSVGL-------------QMVSHCT-TRKIK-SDSPKSAQKF---------------------SLILKILSMI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVSRRS-LHILS----TSKG-LIAGN-LRYIEEDG-----TKV------NCTC--GATAVAVPSNI--QG--IRN----------------------L---VTDAKFVLIVEKDATFQRLLDDNFCNK--LSP-CIMIT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HVPVFTLVDADPHGI-EIMCIY-KYGSMSMSFEA-----HHLTVP---AIRWLGLLPSDLKRLNVP------------------------------------------------------------------KDSLIPLT----------KRDQMKLDSILRR--------PYV-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [358] 'gi|9367033|gb|AAF87090.1| SPO11 [Mus musculus] >gi|5532652|gb|AAD44811.1| Spo11 homolog [Mus musculus] >gi|5453472|gb|AAD43588.' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDALDRHRAS----LLAMVKRGAG---ETPAGATR-VASR-------------------------------------------------------------------------------------------------FDDSVGL-------------RMIPQCT-TRKIR-SDSPKSVKKF---------------------ALILKVLSMI-YKLIQSDTYATK-------------RDIYYTD-----------------SQLF------GNQAAVDSAIDDISCMLKVPRRS-LHVLS----TSKG-LIAGN-LRYMEEDG-----TRV------QCTC--SATATAVPTNI--QG--MQH----------------------L---ITDAKFLLIVEKDATFQRLLDDNFCSR--MSP-CIMVT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFTLVDADPYGI-EIMCIY-KYGSMSMSFEA-----HNLTIP---TIRWLGLLPSDIQRLNIP------------------------------------------------------------------KDSLIPLT----------KHDQMKLDSILKR--------PYI-TYQ-PLWKKELEMM------------ADSKMKAEIQALTL-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLRFGGWI----------------------------------------------------- [358] 'gi|41107578|gb|AAH65463.1| Hypothetical protein LOC402982 [Danio rerio] >gi|45387775|ref|NP 991245.1| hypothetical protein LOC4' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAYQFT----EVDKLREALCESLETVDRCQE-DISS---------------------QDVLTRIEKVIERIVIDVSK-------------------------------GEAPVL-------RLINRSCWNNVRFQESVGL-------------VLKDDVS-PKYLH-CGKPTTATKF---------------------ALILKILSII-YKLVQSDSYATK-------------RDIYYND-----------------PQLF------GSQRMLDSIVDDISCMLKVPRRS-LHILA----TSKG-FISGD-LCYLEEDG-----TKV------DCNS--SSTAVSVSSNV--NG--IRN----------------------I---VSSAKFILIVEKDATFQRLLDDDFCAR--LSP-CIIIT-----------------GKG-------------------VPD-----VNSRLMVRKLWDAL--HVPVFALVDADPHGI-EIMCIY-KYGSVSMAFEA-----HSLTVP---SVLWLGLLPSDIQRYRVP------------------------------------------------------------------EEALIPFA----------KADERKISSLRSR--------SYI-TCQ-PTWEREVETM------------QNLKRKAEIQCLAS-----------------------------------------------------------------------------------IAPH--FLTR---------------VYLPNKLRYGGWI----------------------------------------------------- [383] 'gi|68401227|ref|XP 684956.1| PREDICTED: similar to meiotic recombination protein SPO11 isoform a [Danio rerio]' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAYQFT----EVDKLREALCESLETVDRCQE-DISS---------------------QDVLTRIEKVIERIVIDVSK-------------------------------GEAPVL-------RLINRSCWNNVRFQESVGL-------------VLKDDVS-PKYLH-CGKPTSATKF---------------------ALILKILSVI-YKLVQSDSYSTK-------------RDIYYND-----------------PQLF------GSQRMLDSIVDDISCMLKVPRRS-LHILA----TSKG-FISGD-LCYLEEDG-----TKV------DCNS--SSTAVSVSSNV--NG--IRN----------------------I---VSSAKFILIVEKDATFQRLLDDDFCAR--LSP-CIIIT-----------------GKG-------------------VPD-----VNSRLMVRKLWDAL--HVPVFALVDADPHGI-EIMCIY-KYGSVSMAFEA-----HSLTVP---SVLWLGLLPSDIQRYRVP------------------------------------------------------------------DEALIPFA----------KADERKISSLRSR--------SYI-TCQ-PTWEREVETM------------QNLKRKAEIQCLAS-----------------------------------------------------------------------------------IAPH--FLTR---------------VYLPNKLRYGGWI----------------------------------------------------- [383] 'gi|89511867|dbj|BAE86870.1| Spo11 [Anguilla japonica]' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSERFV----EVDRLQAEIQKYRSSELLLQDAEITS---------------------QDVLLRIEKVILEIITSLTK-------------------------------EEAPVL-------VCHNRSSWANVRFNSAVGL-------------HMGPDSSTVTTIR-SDCSSSVNRF---------------------ALTLKVMSAV-YKLVQSNTFATK-------------RDIYYND-----------------TQLF------RTQRAVDSIVDDISCMLKVPRRS-LHVLA----TSKG-FLSGN-LSYMEEDG-----TKV------NCSS--ASTAVSVSSNV--CG--IKN----------------------I---SSHAKFVLIVEKDATFQRLLDDGFCSK--LAP-CIIIT-----------------GKG-------------------VPD-----VNSRLMVRKLWDTL--HVPIFALVDADPHGI-EIMCIY-KYGSVSMSFEA-----QNLTVP---SVMWLGLLPSDIERLRLP------------------------------------------------------------------KDVLIPFS----------KKDESKLTSLLRR--------PYV-VCQ-PAWEKEMEKM------------LKQRQKAEIQSLTS-----------------------------------------------------------------------------------LAPD--FLTS---------------VYLPNKLRYGGWI----------------------------------------------------- [385] 'gi|73992350|ref|XP 867449.1| PREDICTED: similar to meiotic recombination protein SPO11 isoform b isoform 2 [Canis familiaris]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFAVLDQHRAS----LLAALRRGGG---EPAGGGTP-QAS-------------------------------------------------------------------------------------------------RFEDSVGL-------------QMVTHFT-TRKIK-SDSLKSVKKF---------------------ALILKILSKI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVPRMS-LHILS----TSKG-LIAGN-LRYIEEDG-----TRV------HCTC--GATAVAVPSNI--QG--IRN-----------------------------AKFLLIVEKDATFQRLLDDNFCNR--MSP-CIMIT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFALVDADPHGI-EIMCIY-KYGSMAMSFEA-----HNLTVP---AIRWLGLLPSDIKRLNIP------------------------------------------------------------------RDTLIPLT----------KRDQMKLDSVLKR--------PYV-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [354] 'gi|5453474|gb|AAD43589.1| meiotic DNA transesterase/topoisomerase homolog variant B [Mus musculus] >gi|5453483|gb|AAD43592.1| m' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDALDRHRAS----LLAMVKRGAG---ETPAGATR-VASR-------------------------------------------------------------------------------------------------FDDSVGL-------------RMIPQCT-TRKIR-SDSPKSVKKF---------------------ALILKVLSMI-YKLIQSDTYATK-------------RDIYYTD-----------------SQLF------GNQAAVDSAIDDISCMLKVPRRS-LHVLS----TSKG-LIAGN-LRYMEEDG-----TRV------QCTC--SATATAVPTNI--QG--MQH-----------------------------AKFLLIVEKDATFQRLLDDNFCSR--MSP-CIMVT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFTLVDADPYGI-EIMCIY-KYGSMSMSFEA-----HNLTIP---TIRWLGLLPSDIQRLNIP------------------------------------------------------------------KDSLIPLT----------KHDQMKLDSILKR--------PYI-TYQ-PLWKKELEMM------------ADSKMKAEIQALTL-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLRFGGWI----------------------------------------------------- [354] 'gi|56204502|emb|CAI21520.1| SPO11 [Homo sapiens]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDVLDRHRES----LLAALRRGGR---EPPTGGSR-LAS-------------------------------------------------------------------------------------------------RFEDSVGL-------------QMVSHCT-TRKIK-SDSPKSAQKF---------------------SLILKILSMI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVSRRS-LHILS----TSKG-LIAGN-LRYIEEDG-----TKV------NCTC--GATAVAVPSNI--QG--IRN-----------------------------AKFVLIVEKDATFQRLLDDNFCNK--LSP-CIMIT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HVPVFTLVDADPHGI-EIMCIY-KYGSMSMSFEA-----HHLTVP---AIRWLGLLPSDLKRLNVP------------------------------------------------------------------KDSLIPLT----------KRDQMKLDSILRR--------PYV-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [354] 'gi|47229338|emb|CAG04090.1| unnamed protein product [Tetraodon nigroviridis]' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVLERIESIILGIVTSLSK-------------------------------DEAPVL-------VLPNRSSWANVSFDGSVGL-------------QMTSENS-VISIR-SNCSSSVTKF---------------------AQTVKILSVI-YRLVQSNSFATK-------------RDIYYNN-----------------TQLF------GSQKSVDSIVDDISCLLKVPRRA-LHVLA----TSKG-LISGD-LCYMEEDG-----TRI------ECNS---SQAVAVSSNI--GG--IRN----------------------I---VSSAKFVLIVEKDATFQRLLDDGFCTK--LSP-CIIIT-----------------GKG-------------------VPD-----VNSRLMVRKLWDTL--HIPIFALVDADPHGI-EIMCIY-KYGSVAMSFEA-----HSLTVP---SVMWLGLLPSDLQRLRVP------------------------------------------------------------------QDVLLPLT----------RRDECKLASLLKR--------PYL-TRQ-PEWRREMELI------------QQTKVKAEIQSLSA-----------------------------------------------------------------------------------IAPD--FLTN---------------IYLPNKLRYKGWV----------------------------------------------------- [350] 'gi|9367040|gb|AAF87094.1| SPO11b [Mus musculus] >gi|5733397|gb|AAD49561.1| SPO11 protein [Mus musculus]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFAPMGPEASFFDALDRHRAS----LLAMVKRGAG---ETPAGATR-VASR-------------------------------------------------------------------------------------------------FDDSVGL-------------RMIPQCT-TRKIR-SDSPKSVKKF---------------------ALILKVLSMI-YKLIQSDTYATKRSNAHSVLTLHLHRDIYYTD-----------------SQLF------GNQAAVDSAIDDISCMLKVPRRS-LHVLS----TSKG-LIAGN-LRYMEEDG-----TRV------QCTC--SATATAVPTNI--QG--MQH----------------------L---ITDAKFLLIVEKDATFQRLLDDNFCSR--MSP-CIMVT-----------------GKG-------------------VPD-----LNTRLLVKKLWDTF--HIPVFTLVDADPYGI-EIMCIY-KYGSMSMSFEA-----HNLTIP---TIRWLGLLPSDIQRLNIP------------------------------------------------------------------KDSLIPLT----------KHDQMKLDSILKR--------PYI-TYQ-PLWKKELEMM------------ADSKMKAEIQALTL-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLRFGGWI----------------------------------------------------- [371] 'gi|76612961|ref|XP 602425.2| PREDICTED: similar to meiotic recombination protein SPO11 isoform b isoform 1 [Bos taurus]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFTPRGPEASFFEVLDRHRAS----LLAALRRGGE---EPAGGGMR-LAS-------------------------------------------------------------------------------------------------RFEDSVGL-------------HMVSHCT-TRKIK-SDSPKSVKNF---------------------ALILKIFSMI-YKLVQSNTYATK-------------RDIYYTD-----------------SQLF------GNQTVVDNIINDISCMLKVPRRS-LHILS----TSKG-LIAGD-LKYLEEDG-----TKV------NCT---RATAVAVPSNI--QG--IQN-----------------------------AKFLLIVEKDATFQRLLDDNFCNK--MSP-CIMVT-----------------GKG-------------------VPD-----VNTRLLIKKLWDTF--HIPVFTLVDADPHGI-EIMCIY-KYGSMAMSFEA-----HNLTVP---AIRWLGLLPSDIKRLNIP------------------------------------------------------------------KGTLIPLT----------KRDQMKLDSILKR--------PYI-TCQ-PFWRKEMEIM------------ADSKMKAEIQALTF-----------------------------------------------------------------------------------LSSD--YLSR---------------VYLPNKLKFGGWI----------------------------------------------------- [353] 'gi|72037518|ref|XP 780029.1| PREDICTED: similar to Meiotic recombination protein SPO11 isoform 1 [Strongylocentrotus purpuratus' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKVLALC-YRLVQTDTYSTK-------------RDLYYSD-----------------VQSF------GSQSIVDDIIDNLCCLLQVPRRC-LHVLA----TSKG-LVYGD-LCFTDASG-----SYI------DCSN--NRTGTQVTNHV--GG--ISN----------------------I---HSHAKFVLIIEKDATFQKIIDDGLMDR--MRN-CIIIT-----------------GKG-------------------FPD-----INTRMMVRKLWDTL--HIPVFALVDADPHGL-AILFVY-KFGSRSLSYES-----HSLTVP---SIRWLGVLPSDVKGLRIP------------------------------------------------------------------EKALVPLS----------PSDLKKASHLMRR--------PFY-KEL-PQWMSELQEM------------LHSGYKAEIQSLTA-----------------------------------------------------------------------------------ISET--FLTD---------------VYLPTKLRCGGWL----------------------------------------------------- [283] 'gi|15231162|ref|NP 187923.1| ATP binding / DNA binding / DNA topoisomerase (ATP-hydrolyzing) [Arabidopsis thaliana] >gi|7270975' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGKFA-ISES---------------------TNLLQRIKDFTQSVVVDLAE-------------------------------GRSPKI-------SINQFR---NYCMNPEADCL------------CSSDKPKGQEIFT-LKKEPQTYRI---------------------DMLLRVLLIV-QQLLQENRHASK-------------RDIYYMH-----------------PSAF------KAQSIVDRAIGDICILFQCSRYN-LNVVS----VGNG-LVMGW-LKF-REAG-----RKF------DCLN-SLNTAYPVPVLV--EE--VED----------------------I---VSLAEYILVVEKETVFQRLANDMFCKT--N-R-CIVIT-----------------GRG-------------------YPD-----VSTRRFLRLLMEKL--HLPVHCLVDCDPYGF-EILATY-RFGSMQMAYDI-----ESLRAP---DMKWLGAFPSDSEVYSVP------------------------------------------------------------------KQCLLPLT----------EEDKKRTEAMLLR--------CYL-KREMPQWRLELETM------------LKRGVKFEIEALSV-----------------------------------------------------------------------------------HSLS--FLSE---------------VYIPSKIRREVSSP---------------------------------------------------- [362] 'gi|72037516|ref|XP 801727.1| PREDICTED: similar to Meiotic recombination protein SPO11 isoform 2 [Strongylocentrotus purpuratus' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKVLALC-YRLVQTDTYSTK-------------RDLYYSD-----------------VQSF------GSQSIVDDIIDNLCCLLQVPRRC-LHVLA----TSKG-LVYGD-LCFTDASG-----SYI------DCSN--NRT-------V--NS--NLD----------------------I---HSHAKFVLIIEKDATFQKIIDDGLMDR--MRN-CIIIT-----------------GKG-------------------FPD-----INTRMMVRKLWDTL--HIPVFALVDADPHGL-AILFVY-KFGSRSLSYES-----HSLTVP---SIRWLGVLPSDVKGLRIP------------------------------------------------------------------EKALVPLS----------PSDLKKASHLMRR--------PFY-KEL-PQWMSELQEM------------LHSGYKAEIQSLTA-----------------------------------------------------------------------------------ISET--FLTD---------------VYLPTKLRCGGWL----------------------------------------------------- [276] 'gi|13383478|gb|AAK21002.1| AtSPO11-1 [Arabidopsis thaliana]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGKIA-ISET---------------------TNLLQRIKDFTQSVVEDLAE-------------------------------GRSPKI-------SISQFR---NYCMNPEADCL------------CSSDKPKGQEILT-LKKEPQTYRI---------------------DMLLRVLLIV-QQLLQENRHASK-------------RDIYYMH-----------------PSAF------KAQSIVDRAIGDICILFQCSRYN-LNVVS----VGNG-LVMGW-LKF-REAG-----RKF------DCLN-SLNTAYPVPVLV--EE--VED----------------------I---VSLAEYILVVEKETVFQRLANDMFCKT--N-R-CIVIT-----------------GRG-------------------YPD-----VSTRRFLRLLMEKL--HLPVHCLVDCDPYGF-EILATY-RFGSMQMAYDI-----ESLRAP---DMKWLGAFPSDSEVYSVP------------------------------------------------------------------KQCLLPLT----------EEDKKRTEAMLLR--------CYL-KREMPQWRLELETM------------LKRGVKFEIEALSV-----------------------------------------------------------------------------------HSLS--FLSE---------------IYIPSKIRRELSSP---------------------------------------------------- [362] lcl|Smo_RHL2_1_2_unnamed_protein_product MRCNACWKELEGRAVATVCGHIFCNEDAAKILTCDSTCPLCEQILSKSNMKSLDLNPNDDWTNKDVESQLTVNRATQWKQKCKEMEATFMQKMSEFQGAYQKAVKRVQALEAERDSLLKDKSELEEKYSEKSRQKRKLEEMYDSLRTEYEKTKMNASRPPPALEACSKSRGIPPSIAASSDEKTGTSSCSNANEQAASDLSIQVGGLGHVCATATCQEHLECAAKSAALATQEANIETWSTRTEDGLPALRFGTLNSSTDGSSNRWRRCIRGCWGFFISEFQENADNCWRRHSILSSENGLENEIEQVRVSLAAANHMRVSWISSSSNSPSSVQYGTSPGKYESSATGSKLNYGFLLYKSGTIHGAVLGPLENNTVYYYKCGGMGKEFSFKTPPANLPVTFAVVGDIGQTGWTVTTLEHVQKSSYDVLLFAGDLSYADYYQPRLVEPSASSRPWMVTEGNHEIERIPLISSFRAYNTRWRMPYEESGSDSNLYYSFDVAGAHVLMLGSYADFGQRSPQYKWLQLLDDVIVPQADLAKIDRKRTPWLIAVLHAPWYNSNEAHRNEGDDMMKAMEPLLQAAGTDLLFAGHVHAYERWVLLSRIFAFYFTRFSSQDRMFQGKKDDCGIVHITIGDGGNREGLATKDRREAMAACRWRSAALQSPGAGHGS-EVPP---------------------EELLARIQDFIKEFLSHIKD-------------------------------RSILVI-------SLDKFR-MRRLRSSEDTNL-------------GIFERCEAQERLS---LQTSGRRIRKYYYVSSQLVTDLSFRSFFLVAMLRVLQIV-QSLLQQGKHASK-------------RDLYYTD-----------------PGLFKGGFVITDQATVNQALTDISVRLKCTRSS-LHVVS----VGKG-LIMGS-LRFKDAD------RTI------DCSV-CKSRGYPIPTDA--KM--VTD----------------------I---RSCAEYIIVVEKETVFQRLANDGFCRK--N-N-CIVLT-----------------GRG-------------------YPD-----VATRSFLRLLAAET--NLPVYGLVDADPYGL-DILATY-RFGSLTMAYDA-----EALATP---SIRWLGVFLSDCQTHNVP------------------------------------------------------------------DRCLLPLT----------NDDRRKAEAMLNR--------DYL-EHLAFSWNQQLRLM------------LEKGVKLELEALSA-----------------------------------------------------------------------------------SKFS--ALAD---------------DYIPHKIKAAAYLC---------------------------------------------------- [1049] 'gi|5104364|dbj|BAA79679.1| 385aa long hypothetical type II DNA topoisomerase VI subunit a [Aeropyrum pernix K1] >gi|7674370|sp|' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFGDEVD-IKAR---------------------LRAAEVMYKKFHRLISDVIK-------------------------------GRPPKL-------EIPKRT-LSNTIFDPERGIL------------VIGEEKL-EREFL---NVGESRRF---------------------MQTLLMASII-YQSLIENEYPTI-------------RDLYYKGKHTIVYRDYSGR--KREENTW------DEQKESDSVIQDIEVYTGLFRED-MLILS----KEKG-KVVGN-MRIRSGG------DVI------DLSK-LGHGAYAIEPTP--DL--IEF----------------------L---DVDAEFVLVVEKDAVFQQLHRAGFWKK--Y-K-ALLVT-----------------GSG-------------------QPD-----RATRRFVRRLHEEL--KLPVYIITDSDPYGW-YIYSVY-KVGSITLSYES-----ERLATP---KAKFLGVQMTDIFGYRGK---------------------------------------------------------KPYLSEAERKKFMIKAT----------DKDIKRAKELLNY--------SWIGKN--RRWNVEIRLF------------LKHLVKLEIEAIAS-----------------------------------------------------------------------------------KGLK--FFAY---------------QYIPEKIETGDWID---------------------------------------------------- [385] 'gi|18160702|gb|AAL64037.1| DNA topoisomerase VI (type II ) subunit a [Pyrobaculum aerophilum str. IM2] >gi|18313188|ref|NP 5598' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSTR---------------------SEFLKRLESWGTQLAKAILE-------------------------------LEEPIM-------EIPART-LSNTIWDEKARML------------KLGPEKL-HRRFL---DVKEARKF---------------------MQTVLMLRLI-VEAIREDVYPTI-------------RDLYYNGKHTIVFKDPLGR--THRENTW------DEQSESNAVIEDIEVATNVLREE-MGVSA----DVKG-KIVGP-IVVRSQG------YEL------DASK-FGETALSLPVNV--DA--LEI----------------------V---KVEASYVLVVEKDAIFQRLVREKFWSQ--E-G-AILVT-----------------AKG-------------------MPD-----RATRRFIRRLNEEY--KLPVYVLTDGDPYGW-YIYSVY-KSGSIKLSYES-----ERLATP---DAKFLGLTATDIDTYKIS------------------------------------------------------------------DNYVIAAN----------DRDIKRAQELLRY--------PWF-QK--PEWTREINLF------------LKKKKKVEIEALST-----------------------------------------------------------------------------------HGLK--FLHD----------------YLRDKIRSKKFID---------------------------------------------------- [367] 'gi|86159261|ref|YP 466046.1| DNA topoisomerase, type IIB [Anaeromyxobacter dehalogenans 2CP-C] >gi|85775772|gb|ABC82609.1| DNA' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARL-DAID---------------------KKTVQKIETLAESVLRSVKG-------------------------------GKNPFL-------EIPVRS-LANVQFNPRKRLI------------ELKDQKQ-KRYFF---NVSMAKKF---------------------MQTFLVSEAC-KELIDAGKTTSI-------------RDLYYMTKHALG---------ETRQNTF------EEQEESDPIIEDLEVAIDALREE-LHLFA----SGRG-SMVGP-LSIRDAG------DAI------DLRR-MGSGGWSVPSIV--EEHVVQF----------------------G---KSEARYVLLIEKDAVWKRFNEDKFWAR--E-K-CIIVT-----------------GLG-------------------QPP-----RGVRRIVQRLHSEL--GLPVYVLVDNDPWGF-YIYSVL-KQGSINLAYES-----MRMAVP---KARFIGLSSFDKAKFKLP------------------------------------------------------------------GNVSIRMN----------DQDDARAKQMLAY--------PWF-KD--PKWQREIQEM------------VRSGEKYELEALSR-----------------------------------------------------------------------------------RGIS--FITE---------------EYLPKKLRDRDWLE---------------------------------------------------- [367] 'gi|50918771|ref|XP 469782.1| putative DNA topoisomerase (with alternative splicing) [Oryza sativa (japonica cultivar-group)] >g' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGREKRRRVAALDGEERRRR-QEEA---------------------ATLLHRIRGLVRWVVAEVAA-------------------------------GRSPTV-------ALHRYQ---NYCSSASAAAASPCA--------CSYDVPVGTDVLSLLHRGSHASRL---------------------NVLLRVLLVV-QQLLQQNKHCSK-------------RDIYYMY-----------------PSIF------QEQAVVDRAINDICVLFKCSRHN-LNVVP----VAKG-LVMGW-IRF-LEGE-----KEV------YCVT-NVNAAFSIPVSI--EA--IKD----------------------V---VSVADYILIVEKETVFQRLANDKFCER--N-R-CIVIT-----------------GRG-------------------YPD-----IPTRRFLRYLVEQL--HLPVYCLVDADPYGF-DILATY-KFGSLQLAYDA-----NFLRVP---DIRWLGVFTSDFEDYRLP------------------------------------------------------------------DCCLLHLS----------SEDRRKAEGILSR--------CYL-HREAPQWRLELEAM------------LQKGVKFEIEALSA-----------------------------------------------------------------------------------CSIS--FLSE---------------EYIPKKIKQGRHI----------------------------------------------------- [381] 'gi|10172604|dbj|BAB01408.1| DNA topoisomerase VI, subunit A [Arabidopsis thaliana]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGKFA-ISES---------------------TNLLQRIKDFTQSVVVDLAE-------------------------------GRSPKI-------SINQFR---NYCMNPEADCL------------CSSDKPKGQEIFT-LKKEPQTYR------------------------------IV-QQLLQENRHASK-------------RDIYYMH-----------------PSAF------KAQSIVDRAIGDICILFQCSRYN-LNVIHLIILLCCR-LVMGW-LKF-REAG-----RKF------DCLN-SLNTAYPVPVLV--EE--VED----------------------I---VSLAEYILVVEKETVFQRLANDMFCKT--N-R-CIVIT-----------------GRG-------------------YPD-----VSTRRFLRLLMEKL--HLPVHCLVDCDPYGF-EILATY-RFGSMQMAYDI-----ESLRAP---DMKWLGAFPSDSEVYSVP------------------------------------------------------------------KQCLLPLT----------EEDKKRTEAMLLR--------CYL-KREMPQWRLELETM------------LKRGVKFEIEALSV-----------------------------------------------------------------------------------HSLS--FLSE---------------VYIPSKIRREVSSP---------------------------------------------------- [357] 'gi|13814151|gb|AAK41243.1| DNA topoisomerase VI subunit A (top6A) [Sulfolobus solfataricus P2] >gi|15897848|ref|NP 342453.1| DN' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSEFISKVD-KEAR---------------------RKAASILRDKFLNLVEQLKK-------------------------------GEPLVM-------EIPMRT-LSNAIYDEKRKLL------------LLGEKKL-KRNFL---DMNEAKRF---------------------MQTVLMASII-YDALVSDEYPTI-------------RDLYYRGKHSLLLKSIDGNKIVSEENTW------DEQKESDSVIVDIEVFTSLLREE-MLILS----KEKG-KVVGN-LRIRSGN------DTI------DLSK-TGHGAYAIEPTP--DL--IDF----------------------I---DVDAEFVLVVEKDAVFQQLHRAGFWKQ--Y-K-SILIT-----------------SAG-------------------QPD-----RATRRFVRRLNEEL--KLPVYILTDADPYGW-YIFSVF-RIGSISLSYES-----ERLATP---DAKFLGVSMSDIFGNSRK---------------------------------------------------------KPYLSEAERKNYIIKAK----------EADIKRAEEIKNY--------EWF-KT--KAWEEEINTF------------LHRKAKLEIEAMAS-----------------------------------------------------------------------------------KGLK--FLAF---------------QYIPEKITNKDYIA---------------------------------------------------- [389] 'gi|1926404|emb|CAA71605.1| type II DNA topoisomerase subunit A [Sulfolobus shibatae] >gi|3024738|sp|O05208|TOP6A SULSH Type II' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSEFISKVD-KEAR---------------------RKAANILRDKFLNLVEQLKK-------------------------------GEPLVM-------EIPMRT-LSNAIYDEKRKLL------------LLGEKKL-RRNFL---DLNEAKRF---------------------MQTVLMASII-YDALVSDEYPTI-------------RDLYYRGKHSLLLKSIEGNKIVSEENTW------DEQKESDSVIVDIEVFTSLLREE-MLILS----KEKG-KVVGN-LRIRSGN------DVI------DLSK-TGHGAYAIEPTP--DL--IDF----------------------I---DVDAEFVLVVEKDAVFQQLHRAGFWKQ--Y-K-SILIT-----------------SAG-------------------QPD-----RATRRFVRRLNEEL--KLPVYILTDADPYGW-YIFSVF-RIGSISLSYES-----ERLATP---DAKFLGVSMGDIFGNSRK---------------------------------------------------------KPYLSEAERKNYIIKAK----------DADIKRAEEIKNY--------EWF-KT--KAWQEEINTF------------LQRKAKLEIEAMAS-----------------------------------------------------------------------------------KGLK--FLAF---------------QYIPEKITNKDYIA---------------------------------------------------- [389] 'gi|68567721|gb|AAY80650.1| DNA topoisomerase VI, subunit A [Sulfolobus acidocaldarius DSM 639] >gi|70607073|ref|YP 255943.1| DN' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-TELESKVD-KEIR---------------------KKAGNVLRETFLKLVEMVNN-------------------------------NEPPIM-------EIPKRT-LSNTVYDEKRGLL------------ILGKEKL-KRNFL---DLNEAKRF---------------------MQTTLMASII-YDALVNDEYPTI-------------RDLYYRGKHSIILKDPNGR--AYEENTW------DEQKESDSVIVDIEVFTSLLRED-MLILS----KEKG-KVVGD-MRIRSGN------DVI------DLSK-MGHGAYSIEPTP--DL--IDF----------------------M---DINAEFVLVVEKDAVFQQLHRAGFWKQ--Y-K-AILVT-----------------SAG-------------------QPD-----RATRRFVRRLNEEL--KLPVYILTDADPYGW-YIYSVF-KIGSISLSYES-----ERLATP---NARFLGVSMTDIFGDKGK---------------------------------------------------------KPYLSDQERRNYIIKAK----------DADVKRAMEIKNY--------EWF-KT--KGWQHEISVF------------LDKKSKLEIEAMAS-----------------------------------------------------------------------------------KGLR--FLAF---------------QYIPEKIKNSDFIN---------------------------------------------------- [386] 'gi|40069049|gb|AAR39384.1| NEQ542 [Nanoarchaeum equitans Kin4-M] >gi|41615325|ref|NP 963823.1| DNA topoisomerase VI subunit A [' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDILQKLKQLGEKIYNEFLK-------------------------------NGDPRI-------EFLTRGNIKTVEYDEEKDII------------KLKEKQS-VRRFF---DVGETRRF---------------------TQTLLVAALA-KELVESNKHASL-------------REVYYQLKHTIP---------YINENTF------DEQSESDSVIEDLERALRAIREQ-FGIVA----DRKG-YLYGD-ITLKDRNRG----DEW------NCSK-LGLGGWGIPSTI--EE--IDI----------------------V---DVNADYVLVVEKDAMFERLIEERFPEK--N-R-ALLIA-----------------TKG-------------------QPS-----RGTRRLIRKLRYEV--GLPVYVFTDGDPWGF-YIYSVI-KRGSMNLAMFS-----EQLATP---DAKFIGLTIDDVIKYDLK-------------------------------------------------------------------DVAIQLK----------PIDVKRVKELMEY--------PWF-KN--KEWQRQFNKM------------LKLNIKAEQDALAK-----------------------------------------------------------------------------------HSLE--FVAN---------------KYLPEKIEKGEFLP---------------------------------------------------- [359] 'gi|15622347|dbj|BAB66339.1| 387aa long hypothetical type II DNA topoisomerase VI subunit A [Sulfolobus tokodaii str. 7] >gi|226' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSELTSKVD-KEAR---------------------KKAADTLRQVFVKLIEQINN-------------------------------SEPPTM-------EIPKRT-LGNTIYDEKRKLL------------LLGEEKL-KRSFF---DLNESKRF---------------------MQTVLMASII-YDALINDEYPTI-------------RDLYYRGKHSIILKDPRGK--TYEENTW------DEQKESDSVIMDIEVFTSLLRED-MLILS----KEKG-KVVGD-MRIRSGN------DII------DLSK-MGHGAYSIEPTP--DL--IDF----------------------V---DINAEFVLVVEKDAVFQQLHRAGFWKQ--Y-K-AILVT-----------------SAG-------------------QPD-----RATRRFVRRLNEEL--KLPVYILTDADPYGW-YIYSVF-RIGSISLSYES-----ERLATP---NAKFLGVSMTDIFGDSNK---------------------------------------------------------KPYLSEQERRNYIIKAK----------DADIKRATEIKNY--------QWF-KT--KAWQHEIEIF------------LNKKSKLEIEAMAS-----------------------------------------------------------------------------------KGLK--FLAF---------------QYIPEKIKSKDYIE---------------------------------------------------- [387] 'gi|87290175|gb|EAQ82063.1| DNA topoisomerase VI subunit A [Blastopirellula marina DSM 3645] >gi|87306802|ref|ZP 01088948.1| DNA' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKK----KSVKKQADLPLRSDTSEKVKL-TLRD---------------------KKTIGSLTNLADTVVASAQK-------------------------------TKDPRL-------EIPTRS-LSNVRYNKSQRIL------------EMGKNTT-ARQLF---NLNQAKSY---------------------MQTMLAAAGC-KRLVESGKTTSI-------------RGLYYLMKHTIA---------GTKEETF------SDQAESDPIIEDLEVLLESLREE-LHLYA----QQRG-SMVGN-IILNDKG------DTI------DCSR-MGSGGYGIPSIV--EADVIQF----------------------R---ECGADFVLHVEKDTVWQRFNEDKFWKK--H-N-CILTH-----------------GSG-------------------QPP-----RGVRRLLHRLHNEL--KLPIYCVFDNDPWGY-YIYSVI-KQGSINLAYES-----KRMAVP---EAKFLGLRAIDYERCNLN------------------------------------------------------------------PSVQIALN----------DTDRKRAKQIAKY--------PWFEQK--KTWQKEIQKL------------LDNGFKLEVEALIS-----------------------------------------------------------------------------------QGLS--YVTD---------------VYVPERLEDRTWLD---------------------------------------------------- [389] 'gi|30696943|ref|NP 176582.2| ATP binding / DNA binding / DNA topoisomerase (ATP-hydrolyzing) [Arabidopsis thaliana] >gi|7270977' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEESS-GLSSMKFFSDQHLSYADILLP----HEARARIEVSVLNLLRILNS--------------------------------PDPAISDLSLINRKRSNSCINKGIL-TDVSYI------------FLSTSFT-KSSLT---NAKTAKAF---------------------VRVWKVMEIC-FQILLQEKRVTQ-------------RELFYKLLCDS-------------PDYF------SSQIEVNRSVQDVVALLRCSRYS-LGIMA----SSRG-LVAGR-LFLQEPGK-----EAV------DCSA-CGSSGFAITGDL--NL--LDN--------------------TIM---RTDARYIIIVEKHAIFHRLVEDRVFNH--I-P-CVFIT-----------------AKG-------------------YPD-----IATRFFLHRMSTTFP-DLPILVLVDWNPAGL-AILCTF-KFGSIGMGLEA-----YRYAC----NVKWIGLRGDDLNL--IP------------------------------------------------------------------EESLVPLK----------PKDSQIAKSLLSS--------KIL-Q---ENYIEELSLM------------VQTGKRAEIEALYC-----------------------------------------------------------------------------------HGYN--YLGK----------------YIATKIVQGKYI----------------------------------------------------- [383] 'gi|53125146|emb|CAE53723.1| topoisomerase 6 subunit A [Oryza sativa (indica cultivar-group)]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEAG-VAAASLFGADRRLCSADILPP----AEVRARIEVAVLNFLAALTD-------------------------------PAAPAISALPLISRGAANRGLRRALLRDDVSSV------------YLSYASC-KRSLT---RANDAKAF---------------------VRVWKVMEMC-YKILGEGKLVTL-------------RELFYTLLSES-------------PTYF------TCQRHVNQTVQDVVSLLRCTRQS-LGIMA----SSRG-ALIGR-LVLQGPEE-----EHV------DCSI-LGPSGHAITGDL--NV--LSK--------------------LIF---SSDARYIIVVEKDAIFQRLAEDRIYSH--L-P-CILIT-----------------AKG-------------------YPD-----LATRFILHRLSQTYP-NMPIFALVDWNPAGL-AILCTY-KYGSISMGLES-----YRYAC----NVKWLGLRGDDLQL--IP------------------------------------------------------------------QSAYQELK----------PRDLQIAKSLLSS--------KFL-Q---DKHRAELTLM------------LETGKRAEIEALYS-----------------------------------------------------------------------------------HGFD--FLGK----------------YVARKIVQGDYI----------------------------------------------------- [385] lcl|Ppa_RHL2_340_2_unnamed_protein_product ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMEARRSMCLADDADP----SEHRACRRFFI----------------------------------------RLKPLYLELRLCTSLAAQISRSERNAGADEEGV------------YLMDATY-EKDFT---VRNSGKSF---------------------FLVWKVMQIC-YQLLGIGKQATQ-------------REIFYNILSTS-------------SSYI------TSQNQVNSAIQDAVAVLLCTRRS-LGILA----SSKG-AVVGR-LVIKEHGG-----DTV------DCSN-LGSSSYPISADM--NM--KQH----------------------F---YSDARYILVIEKDAIFQRLVEERFFLK--V-P-CIIMT-----------------AKG-------------------FPD-----LASRALLHRLHQEFP-SMLIFALVDWNPAGL-AIICTY-RFGSIRMGLEA-----PRYVC----DVKWLGLRNRDALTY-VP------------------------------------------------------------------ATAFTSLT----------DRDMTQARSLLAS--------KML-QNH-KQYKQEILEM------------LTFGQKAEIEALYA-----------------------------------------------------------------------------------HGYE--FLAK----------------FITKKIVRQDFI----------------------------------------------------- [368] 'gi|50941305|ref|XP 480180.1| putative SPO11 protein [Oryza sativa (japonica cultivar-group)] >gi|37805855|dbj|BAC99506.1| putat' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEAG-VAAASLFGADRRLCSADILPP----AEVRARIEVAVLNFLAALTD-------------------------------PAAPAISALPLISRGAANRGLRRALLRDDVSSV------------YLSYASC-KRSLT---RANDAKAF---------------------VRVWKVMEMC-YKILGEGKLVTL-------------RELFYTLLSES-------------PTYF------TCQRHVNQTVQDVVSLLRCTRQS-LGIMA----SSRG-ALIGR-LVVQGPEE-----EHV------DCSI-LGPSGHAITGDL--NV--LSK--------------------LIF---SSDARYIIVVEKDAIFQRLAEDRIYSH--L-P-CILIT-----------------AKG-------------------YPD-----LATRFILHRLSQTYP-NMPIFALVDWNPAGL-AILCTY-KYGSISMGLES-----YRYAC----NVKWLGLRGDDLQL--IP------------------------------------------------------------------QSAYQELK----------PRDLQIAKSLLSS--------KFL-Q---DKHRAELTLM------------LETGKRAEIEALYS-----------------------------------------------------------------------------------HGFD--FLGK----------------YVARKIVQGDYI----------------------------------------------------- [385] 'gi|50941303|ref|XP 480179.1| putative SPO11 protein [Oryza sativa (japonica cultivar-group)] >gi|37805856|dbj|BAC99507.1| putat' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEAG-VAAASLFGADRRLCSADILPP---------------------------------------------------------APAISALPLISRGAANRGLRRALLRDDVSSV------------YLSYASC-KRSLT---RANDAKAF---------------------VRVWKVMEMC-YKILGEGKLVTL-------------RELFYTLLSES-------------PTYF------TCQRHVNQTVQDVVSLLRCTRQS-LGIMA----SSRG-ALIGR-LVVQGPEE-----EHV------DCSI-LGPSGHAITGDL--NV--LSK--------------------LIF---SSDARYIIVVEKDAIFQRLAEDRIYSH--L-P-CILIT-----------------AKG-------------------YPD-----LATRFILHRLSQTYP-NMPIFALVDWNPAGL-AILCTY-KYGSISMGLES-----YRYAC----NVKWLGLRGDDLQL--IP------------------------------------------------------------------QSAYQELK----------PRDLQIAKSLLSS--------KFL-Q---DKHRAELTLM------------LETGKRAEIEALYS-----------------------------------------------------------------------------------HGFD--FLGK----------------YVARKIVQGDYI----------------------------------------------------- [363] lcl|Smo_RHL2_8_1_unnamed_protein_product --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?DIGQTGWTVTTLEHVQKSTYDVLLFAGDLSYADYYQPRLVEPSASSRPWMVTEGNHEIERIPLISSFRAYNTRWRMPYEESGSDSNLYYSFDVAGAHVLMLGSYADFGQRSPQYKWL---------QADLARIDRKRTPWLIAVLHAPWYNSNEAHRNEGDDMMKAIESLLQAAGTDLLFAGHVHAYERW-----------------DRMFQGKKDDCGIVHITIGDGGNREGLATK--RETMAACRWRSAALQSPGAGHGS-GVPP---------------------EELLARIQDFIKEFLSRIKD-------------------------------RSMLVI-------SLDKFR-MRKLRSSEDTNL-------------GIFERCEAQENLS---LQTSGRRI---------------------LAMLRVLQIV-QSLLQQGKHASK-------------RDLYYTD-----------------PGF---------------------------------------------------CRQRDAD------RTI------DCSV-CKSRGYPIPTDA--KM--VTD----------------------I---SSCAEYIIVVEKETVFQRLANDGFCRK--N-N-CIVLT-----------------GRG-------------------YPD-----VATRSFLRLLAAET--KLPVYGLVDADPYGL-DILATY-RFGSLTMAYDA-----EALATP---SIRWLGVFLSDCQTHNVP------------------------------------------------------------------DRCLLSLT----------NDDRRKAEAMLNR--------DYL-KHLAFSWNQQLRLM------------LEKGVKLELEALSA-----------------------------------------------------------------------------------SKFS--ALAD---------------DYIPHKIKAAAYLC---------------------------------------------------- [552] lcl|Smo_RHL2_5_3_unnamed_protein_product ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQVRARIEVVVRRFLATLIS--------------------------------HRPRIMPLSMA---------------------------------RFSFPDS-TLSFT---KSGSMKRY---------------------FRVWKMLELC-YQLLTLGKKATQ-------------REIFYRLLCDA-------------S-----------DEKAKTMHADVVGILKCSRYS-LGILA----SARG-AIVGR-LVIQELNR-----EPV------DCTK-IGINGYIIDGDL--EL--LQN--------------------LTL---TSDARYILVIEKDAVFQRLSEDRFFQT--I-P-SILIT-----------------AKG-------------------YPD-----LASRVMLHKLHRSFP-LLPILALVDWNPCGL-GIICTY-KFGSKQ----------NILAVC---DVKWLGVSSEDLPR--IP------------------------------------------------------------------PEYFVELS----------ARDRQLAKGLLSS--------AML-QNH-PRYREELERM------------IQAGKRVEIEALYA-----------------------------------------------------------------------------------HGYK--SLSS----------------YVAQKIVQMRYF----------------------------------------------------- [330] 'gi|2495937|sp|Q57815|TOP6A METJA Type II DNA topoisomerase VI subunit A >gi|1591076|gb|AAB98358.1| DNA topoisomerase VI, subuni' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVKLPAIS-KKPR---------------------EIAKQKIIELAKKMYEDLMK-------------------------------GKRPKI-------TMPIRS-LSNAMFDKEKGSF------------TLVGKEK-ARTL----TVNQAKIF---------------------AQTTKMLEFA-KQLLETDDFSTL-------------REAYYVSKNWG-------------EARF------DDQQASNNVIEDLEAALGVLREH-LGFIP----EEDGSSVVGP-LKIIEETPEGE--LVV------DCTK-LGTGAYNIPNDV--TK--LNL--------------------------ETDADFILAIETSGMFARLNAERFWDK--H-N-CILVS-----------------LKG-------------------VPA-----RATRRFIKRLHEEH--DLPVLVFTDGDPYGYLNIYRTL-KVGSGKAIHLA-----DKLSIP---AARLIGVTPQDIIDYDLP---------------------------------------------------------------------THPLK----------EQDIKRIKDGLKN--------DDF-VRSFPEWQKALKQM------------LDMGVRAEQQSLAK-----------------------------------------------------------------------------------YGLK--YVVN---------------TYLPEKIKDESTWLP--------------------------------------------------- [369] 'gi|77556616|gb|ABA99412.1| spo11 protein homolog, putative [Oryza sativa (japonica cultivar-group)]' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLRDGFSNNKLLDDFGYGGIQPNRNHPSLKILDVSKDVRLYDVKRVCNKETVLAGHENVVNPLLWIPFKWLRYDYDWSSTSNYTPGLYPVWKSSHHFIYVNFCNFQGNILAPVLGTITKVFNQTEPTQICLIRQQTSKYHETLRQHFFSGIAQDLRSPMDDSTDDDSYHPRKHYAYDRQVSSSRWRTSREYIRGPGPETHTTESAQDGQDPPAGVYSYGYFSGSGNDPQVQGHFVPEIQKYNPYVIFKGEQLPV----PIWELPEEKVQDFHDRYFIAK-DKSR---------------------VEARKTLNRLLEGNINTIER-------------------------------GHGYKF-------NIPKYT--DNMEFNEEVKV-S-----------LAKAGKTISRSFC---NANQREVA---------------------SRTGYTIDLI-ERTLGAGLNISK-------------RTVLYTN-----------------KDLF------GDQSKSDQAINDICALTNIRRGS-LGIIA----AEKG-IVVGN-IFLELTNG-----KSI------SCSI-----GVQIPHRL--DQ--IKD--------------------VCVEIGSRNIEYILVVEKHTMLNYLLEMDYHTN--N-N-CIILT-----------------GCG-------------------MPT-----LQTRDFLRFLKQRT--GLPVFGLCDPDPEGI-SILATY-ARGSCNSAYDN-----FNISVP---SICWVGLSSSDMIKLNLS------------------------------------------------------------------ETNYSRLS----------REDKTMLKNLWQD--------DLS-----DVWKRRIEEM------------ISFDKKASFEAIHS-----------------------------------------------------------------------------------LGFD--YFAT---------------NLLPDMINKVR-----------------------------------EGYVQVQEKKEPQDTEASED [646] lcl|Smo_RHL2_20_1_unnamed_protein_product -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASEIC-RHGLTPFESNELSSTADVVSPEEPGMQVRARIEVVVRRFLATLIS--------------------------------HRPRIMPLSMA---------------------------------RFSFLDS-TLSFT---KSGSMKRY---------------------FRVWKMLELC-YQLLTLGKKATQ-------------REIFYRLLCDA-------------SEYFQ-----CQEQKAKTMHADVVGILKCSRYS-LGILA----SARG-AIVGR-LVIQELNR-----EPV------DCAK-IGINGYIIDGDL--EL--LQN--------------------LTL---TSDARYILVIEKDAVFQRLSEDRFFQT--I-P-SILIT-----------------AKG-------------------YPD-----LASRVMLHKLHRSFP-LLPILALVDWNPCGL-GIICTY-KFGSKQ----------NILAVC---DVKWLGVSSEDLPR--IT------------------------------------------------------------------PEYFVELS----------ARDRQLAKGLISS--------AML-QNH-PRYREELERM------------IQAGKRVEIEALYA-----------------------------------------------------------------------------------HGYK--SLSG----------------YVAQKIVQMRYF----------------------------------------------------- [367] 'gi|18893722|gb|AAL81702.1| type II DNA topoisomerase subunit a [Pyrococcus furiosus DSM 3638] >gi|22654150|sp|Q8U0K9|TOP6A PYRF' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLKRGKPKEKF-SYDP---------------------QKVLKKLEDLAYKILEEVKA-------------------------------GKNPYF-------DVPTRG-LSNVYFDEEARLI------------KLGDKLS-RRYFL---NVAHARKF---------------------MQTLILMAYV-KRLVSEGKHASL-------------REAYYANKHTIP---------GTHENTF------EDQSESDPIIEDLERMLGVLREE-MHITA----DRRG-YVYGD-IVIKDGE------DEF------NASK-LGMGGWAVPGTV--EH--IQF----------------------P---EINVDYVLVVETAAMADRLIEEKYPKR--E-R-ALIIA-----------------TQG-------------------QAS-----RGVRRLIHRLHYEE--GLPIIVFTDGDPYGW-YIYSTI-KQGSINLAYLS-----EKLATP---DAKFVGMTMDDIKEYGLE-------------------------------------------------------------------HVTEKLKGIPPDKKGGPTGDYKRLIEELNY--------PWF-QN--KEWQRQLKLA------------LKWGVRIEQQALAN-----------------------------------------------------------------------------------KSLE--FVAK---------------EYLPEKIREGKLLP---------------------------------------------------- [382] 'gi|5458027|emb|CAB49517.1| Top6A DNA topoisomerase VI, subunit A [Pyrococcus abyssi GE5] >gi|13124622|sp|Q9V134|TOP6A PYRAB Typ' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLKRQKPKEKF-SYDP---------------------QKVLKKLEDLAWKILEEVKS-------------------------------GKNPYF-------DVPTRG-LNNVYFDEEARLI------------KLGDKLS-RRYFL---NVAHARKF---------------------TQTLILMAYI-KRLVSEGKHASL-------------REAYYANKHTIP---------GTRENTF------EDQSESDPIIEDLERMLGVLREE-MHITA----DRRG-YIYGD-IVIKDGE------DEF------NASK-LGTGGWAVPGTV--EH--IQF----------------------P---EVNVDYVLVVETAAMADRLIEEKYPKK--E-N-CLIVA-----------------TQG-------------------QAS-----RGVRRLIHRLHYEE--GLPIIVFTDGDPYGW-YIYSTI-KQGSINLAYLS-----EKLATP---DAKFVGMTMDDIKEYNLE-------------------------------------------------------------------HVTEKLKGIPPDKKGGPTGDYKRLIEELNY--------PWF-QN--KEWQRQLKLA------------LKWGVRIEQQALAN-----------------------------------------------------------------------------------KSLE--FVAK---------------EYLPEKIREGKLLP---------------------------------------------------- [382] gi|7994697|sp|O59209|TOP6A_PYRHO_Type_II_DNA_topoisomerase_VI_subunit_A -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLKRQKPKEKF-SYDP---------------------QKVLKKLEDLAWKILEEAKS-------------------------------GKNPYF-------DVPTRG-LNNVYFDEESRLI------------RLGDRLS-RRYFL---NVAHARKF---------------------MQTLILMAYI-KRLVSEGKHASL-------------REAYYANKHTVP---------GTRENTF------EDQSESDPIIEDLERMLGVLREE-MHITA----DRRG-YIYGD-IVIKDGE------DEF------NASK-LGTGGWAVPGTV--EH--IQF----------------------P---EINVDYVLVVETAAMADRLIEEKYPKR--E-N-CLIVA-----------------TQG-------------------QAS-----RGVRRLIHRLHYEE--GLPIIVFTDGDPYGW-YIYSTI-KRGSINLAYLS-----EKLATP---DAKFVGMTMDDIKEYNLE-------------------------------------------------------------------NVTEKLKGIPPDKKGGPTGDYKRLIEELNY--------PWF-QD--KEWQRQLKLA------------LKWGVRIEQQALAN-----------------------------------------------------------------------------------KSLE--FVAK---------------EYLPEKIREGKLLP---------------------------------------------------- [382] 'gi|57159057|dbj|BAD84987.1| type II DNA topoisomerase VI, subunit A [Thermococcus kodakarensis KOD1] >gi|57640733|ref|YP 183211' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPKRKIQRERPKEKF-SYDP---------------------RKVLKMLDEHARRILEDIKA-------------------------------GKNPHF-------DIPMRG-LSNVYFDEKSRLI------------KMGDKLS-RRYFL---NVAHARKF---------------------MQTLLIMAYV-KRLVSEGKHASL-------------REAYYANKHTIP---------GTRENTF------EDQSESDPIIEDLERMFGVLREE-MHITA----DRRG-YIYGD-IVIRDGE------DEF------NASR-LGSGGWAVPGTV--EH--IQF----------------------P---EINVDYALVVETAAMADRLIEEKFPKR--E-N-ALIIA-----------------TQG-------------------QAS-----RGVRRLIHRLHYEE--GLPIIVFTDGDPYGW-YIYSTI-KQGSINLAYLS-----DKLATP---ESKFVGMTMDDIKKYGLE-------------------------------------------------------------------NVTEKLKGIPPNKKGGPTGDYKRILEEMNY--------PWF-QN--KEWQRQLQLA------------LKWGVRIEQQALAN-----------------------------------------------------------------------------------KSLE--FVAK---------------EYLPEKINNGDLLP---------------------------------------------------- [385] 'gi|19886903|gb|AAM01727.1| DNA topoisomerase VI, subunit A [Methanopyrus kandleri AV19] >gi|20093950|ref|NP 613797.1| DNA topoi' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------SEALQRLREFAKQVLKCVEK---------------------------------DEPV-------RIPKRT-TSNIRYDPEREIF------------TLGPDKL-ERRPR---TLKGSKKL---------------------AQMLSVAAFA-KELVEKGRSATL-------------REIYYTSEGW--------------EVDF------KDQRESDAIVEDLEATLGLKREE-FGVWP----EEDGAAVYGD-LLVREDG------VEI------HAER-AGISGYNIPPNV--DA--VEI----------------------L---DCGAERVIAVETMGMYRRLVQERAHEK--L-N-ALIVG-----------------LKG-------------------QAA-----RATRRLLRRLNEEL--GLPVYVFTDGDPYGW-HIYMVI-RSGSAKAAHLN-----EELACP---DAKFIGVTATDIVEYDLP---------------------------------------------------------------------TEPLK----------KTDYKRIEELRRD--------PRY-YD--PFWKKELDLL------------EKLGKKAEQQAFAK-----------------------------------------------------------------------------------YSLD--YVVK---------------EYLPAKLDELE------------------------------------------------------- [346] 'gi|2622109|gb|AAB85504.1| conserved protein [Methanothermobacter thermautotrophicus str. Delta H] >gi|3122955|sp|O27089|TOP6A M' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRR---------------------EIAINKLKSLGDVILDDVTQ-------------------------------GRIPRI-------KVPSRG-TSNIIYDEDKRHY------------VLGDRYG-TRSMG---NVKQIKKI---------------------GQMLYTANFC-KDLVAREKTATL-------------RELYYISEGW--------------EVDF------ADQQESNIVGEDLEVTLGMTREE-LGLMP----EEDGASVYGA-LTVREGD------IEI------DALR-SGKSGYNISPTI--DE--VEF----------------------V---DHDVERVIAVETMGMFHRLVQEKAYKK--F-D-ALIVG-----------------LKG-------------------QAA-----RATRRFIKRVNEEL--NLPVYICNDGDPWGF-HIAMVI-ISGSAKLAHVN-----HQLATP---DAKFLGVTASDIINYDLP---------------------------------------------------------------------TDPLK----------DVDVVRLKELLQD--------PRY-RG--DFWKTEIKKM------------LTIGKKAEQQSFSK-----------------------------------------------------------------------------------YGLE--YVVD---------------TYLPEKLEAVENQ----------------------------------------------------- [353] 'gi|6573668|pdb|1D3Y|B Chain B, Structure Of The Dna Topoisomerase Vi A Subunit >gi|6573667|pdb|1D3Y|A Chain A, Structure Of The' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVNQAKIF---------------------AQTTKMLEFA-KQLLETDDFSTL-------------REAYYVSKNWG-------------EARF------DDQQASNNVIEDLEAALGVLREH-LGFIP----EEDGSSVVGP-LKIIEETPEGE--LVV------DCTK-LGTGAYNIPNDV--TK--LNL--------------------------ETDADFILAIETSGMFARLNAERFWDK--H-N-CILVS-----------------LKG-------------------VPA-----RATRRFIKRLHEEH--DLPVLVFTDGDPYGYLNIYRTL-KVGSGKAIHLA-----DKLSIP---AARLIGVTPQDIIDYDLP---------------------------------------------------------------------THPLK----------EQDIKRIKDGLKN--------DDF-VRSFPEWQKALKQM------------LDMGVRAEQQSLAK-----------------------------------------------------------------------------------YGLK--YVVN---------------TYLPEKIKDESTWLP--------------------------------------------------- [301] 'gi|55244408|gb|EAA05541.2| ENSANGP00000012461 [Anopheles gambiae str. PEST] >gi|58377679|ref|XP 309793.2| ENSANGP00000012461 [A' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWNTRRL---------------------QLMVQLLATI-YQLLTTGSSCTK-------------RELYYLH-----------------LELA------QTPAYTYATLEDVCALLDADPWE-LHVYN----TSKG-LIAGP-IVLTLSDG-----QRI------DCN---GRWGTAVPLDV--GS--VTE----------------------I---RLAAKLVLVVEKDTVFKRLLEDGILST--FPDTLVLIT-----------------AKG-------------------YPD-----VSTRLLLKKISDWT--HVPIYGLMDADPHGI-EIFCVY-KFGSLAMVHQQ-----RSLAVP---TMRWIGLFPSDIELLGLQ---------------------------------------------------------------------GVPLR----------EGELKRIEQMTKR--------PYT----EGHIQRELLLL------------RQLATKVEIESLYN-----------------------------------------------------------------------------------IASD--FITT---------------VYLKGKLKECISL----------------------------------------------------- [287] 'gi|84490128|ref|YP 448360.1| type II DNA topoisomerase VI, subunit A [Methanosphaera stadtmanae DSM 3091] >gi|84373447|gb|ABC57' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-MKHK---------------------EIALNKLRGMGDEVLEKILQ-------------------------------EEVPSL-------KIPSRG-TGNIIYNQDKRYF------------ELGERKG-TRSLG---NVKQIKKM---------------------AQMMCVGNFC-KELVNIQKTATM-------------REMYYVSEGW--------------DVGF------DNQQESNNITEDIEVTLGVSREN-LGLLP----EEDGASVYGD-ITLRDDD------VEF------NAKK-LGKSGYTIPPTI--DD--VEF----------------------V---DSNVERIIAVETMGMYHRMVQEKAYDR--F-N-TLIVG-----------------LKG-------------------QAA-----RATRRFIRRASDEL--QVPVYICNDGDPWGF-HIAMVI-ISGSAKLAHVN-----HDLATP---DAKFLGVTASDIENYDLP---------------------------------------------------------------------TDKLK----------DIDVARLKELAAD--------PRY-KA--DFWQTEIKKM------------IKLGRKAEQQSFSK-----------------------------------------------------------------------------------YGLE--YIVD---------------NYFPNKISAIEGKPIE-------------------------------------------------- [357] 'gi|45047875|emb|CAF30993.1| DNA topoisomerase VI A [Methanococcus maripaludis S2] >gi|45359000|ref|NP 988557.1| DNA topoisomera' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYS----FHLFDSYLYYFLLKCGETVIT-SEER---------------------NLAAKKLLKLANGMYEDIIR-------------------------------GKRPKL-------TFPIRS-LANAKFDVEKGTF------------AILGKEK-DRML----TVNQAKIF---------------------AQTIKMMEFS-KGLLDTNDFSTL-------------REAYYVSKNWG-------------EARF------DDQQPSNGVIEDIEAASEFLRED-LGFIP----EEDGAAVIGP-LRIVDRTAEGDE-IKI------DCTK-LGSGAYSIPNDV--TK--LEF--------------------------ETKADFILAIETAGMFARLNAEGFWKK--H-N-CILIS-----------------LKG-------------------VPA-----RATRRFIKRLNEEY--KLPILVFTDGDPYGYLNIYRTL-KVGSGKAVHLA-----DKLAVP---EARLIGVTPQDIVDYELP---------------------------------------------------------------------THPLK----------DHDIKRLKDGLKN--------DDF-VKSFPQWQNALVQM------------ADSKVRAEQQSLAK-----------------------------------------------------------------------------------YGLK--YVVE---------------EYLPAKVEDSSTWLP--------------------------------------------------- [419] lcl|Smo_RHL2_9_2_unnamed_protein_product -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAACRWRSVELQSPGAGHGS-EVTP---------------------EELLARIQDFIKEFLSHIKD-------------------------------RSILVI-------SMDKFR-MRRLRSSEDTNLFLILACCAACLRSGIFERCEAQERLS---LQTSGRRI---------------------LAMLRVLQIV-QSLLQQGKHASK-------------RDLYYTD-----------------P----------------------------------------------------------------------------------------------------D----------------------I---SSCAEYIIVVEKETVFQRLANDGFCRK--N-N-CIVLT-----------------GRG-------------------YPD-----VATRSFLRLLAAET--NLPVYGLVDADPYGL-DILATY-RFGSPTMAYDA-----EALATP---SIRWLGVFLSDCQTHNVP------------------------------------------------------------------DRCLLSLT----------NDDRRKAEAMLNR--------DYL-KHLAFSWNQQLRLM------------LEKGVKLELEALSA-----------------------------------------------------------------------------------SKFS--ALAD---------------DYIPHKIKAAAYLC---------------------------------------------------- [318] 'gi|11498545|ref|NP 069773.1| DNA topoisomerase VI subunit A [Archaeoglobus fulgidus DSM 4304] >gi|2649657|gb|AAB90299.1| DNA to' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-KEIE---------------------RRCLRALIGIVQNIYDQMKA-------------------------------GQVPEL-------HIATRT-KYNIEFNEESEVW------------VYGDRKS-VRSAK---TVKGAYRI---------------------LKMTYVIGFL-KEQLNLNKSSTL-------------RELYYISEGWG-------------AAKF------EEQPESDRLVEDLEILTNFQREH-FHIRP----EEDGATVIGP-LRVREETRRGV--REI------HCQDDVGEGGYQIPVNV--DK--IEF----------------------V---DHDAKFVIAIETGGMRDRLVENGFDEK--Y-D-AIIVH-----------------LKG-------------------QPA-----RSTRRLLRRLNTEL--NLPVVVFTDGDPWSY-RIFASV-AYGSIKSAHLS-----EYLATP---AAQFVGIRPTDIVKYDLP---------------------------------------------------------------------ADKLT----------EEDIKALNAILTD--------PRF-DS--EFWKKEVNLQ------------LEINKKSEQQALAK-----------------------------------------------------------------------------------YGLD--YVTD---------------VYLPERLSELGVI----------------------------------------------------- [360] 'gi|10580448|gb|AAG19326.1| DNA topoisomerase VI subunit A; Top6A [Halobacterium sp. NRC-1] >gi|13124612|sp|Q9HR32|TOP6A HALSA T' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSETH-TSDE---------------------TEARDQLLAIAEQFYDQFAD-------------------------------GDIPRM-------SLPTRS-KSNIEYDEDADVW------------VYGDSQS-TRSAN---SVRGARKL---------------------LKSVYTVDFL-AQQLDEGRSSTL-------------RELYYLSESWDEA-----------EAQF------NDQSESDKLVEDLEIVSGVKRED-FHMRP----EESGAKVMGP-LRLREQTRRGD--REI------HCQEDVGQGGYQIPNNP--DT--IDF----------------------L---DTDADFVLCVETGGMRDRLVENGFDDD--Y-N-AIVVH-----------------LGG-------------------QPA-----RATRRLTKRLHDEL--DLPVTVFTDGDPWSY-RIYGSV-AYGSIKSAHLS-----EYLATP---QAQFIGIRPQDIVDYDLP---------------------------------------------------------------------TDPLS----------DSDVNALESELED--------PRF-QS--DFWTEQIGLQ------------LDIDKKAEQQALAS-----------------------------------------------------------------------------------RGLD--FVTD---------------TYLPERLAEMGVL----------------------------------------------------- [366] 'gi|45552753|ref|NP 995901.1| meiotic W68 CG7753-PA [Drosophila melanogaster] >gi|7302468|gb|AAF57553.1| CG7753-PA [Drosophila m' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------DEFSENIERIALELLSNLVH-------------------------------GNATL--------SVPRNS-SGNVISEYR------------------------RVSYN---NRGSRHSF---------------------CVLIYMLSRV-HRLQVRGGSFTV-------------RGLYYDN-----------------PLLV------RSQSRIAEARLDVCRMLRTSPLS-LGILA----ASKG-LVAGD-LRLLMTNG-----DVL------DSSL--YGGPLTLPTDP--EK--IDR----------------------I---ETLAEFVLIVEKESVFESLLSRNVFGT--FERRFILIT-----------------GKG-------------------YPD-----CCTRRIVHRLTEEN--QLAAYILVDADPFGV-EIMLVY-RHGSKSMSFSS-----QGLTTP---ALRWIGLHPSEIPALGTG---------------------------------------------------------------------AVALV----------AGDNKKINDLLAR--------HDL----EPGVRQELRML------------QDVQLKAEIESVID-----------------------------------------------------------------------------------------FLTD---------------DYIPNKINRNLFL----------------------------------------------------- [331] 'gi|21228520|ref|NP 634442.1| DNA topoisomerase VI subunit A [Methanosarcina mazei Go1] >gi|34395891|sp|Q8PUB7|TOP6A METMA Type' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGEKGSKT-RKGD---------------------ALAREKLLEIAEKIYNQFEE-------------------------------EVVPSV-------SLPSRT-KANLEYSDESDVW------------VYGDRES-ERSAK---TVKGAFQL---------------------LKTTYATDFLINEHLARNRGSTL-------------RELYYISEGWD-------------YAKF------KEQGESDRLIEDLEILTSLQREY-FHMRP----EEDGATMFGP-IEITEQTKRGE--RNI------HCQKDVGEGGYQIPFNV--EN--IEF----------------------Q---KHDASMIIAIETGGMYARLMENGFDEA--Y-N-AILVH-----------------LKG-------------------QPA-----RSTRRIIKRMNEEL--GIPVAVFTDGDPWSY-RIYASV-AYGAIKSAHLS-----EFMATP---AAKFLGLQPSDIVEYELS---------------------------------------------------------------------TDKLT----------EQDVSALRSELSD--------PRF-ES--DYWKEQIQLQ------------LDIGKKAEQQAFAG-----------------------------------------------------------------------------------KGLD--FVTE---------------VYLPNRLKEMGMI----------------------------------------------------- [369] 'gi|3257992|dbj|BAA30675.1| 301aa long hypothetical typeII DNA topoisomerase subunit A [Pyrococcus horikoshii OT3] >gi|14591345|' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQTLILMAYI-KRLVSEGKHASL-------------REAYYANKHTVP---------GTRENTF------EDQSESDPIIEDLERMLGVLREE-MHITA----DRRG-YIYGD-IVIKDGE------DEF------NASK-LGTGGWAVPGTV--EH--IQF----------------------P---EINVDYVLVVETAAMADRLIEEKYPKR--E-N-CLIVA-----------------TQG-------------------QAS-----RGVRRLIHRLHYEE--GLPIIVFTDGDPYGW-YIYSTI-KRGSINLAYLS-----EKLATP---DAKFVGMTMDDIKEYNLE-------------------------------------------------------------------NVTEKLKGIPPDKKGGPTGDYKRLIEELNY--------PWF-QD--KEWQRQLKLA------------LKWGVRIEQQALAN-----------------------------------------------------------------------------------KSLE--FVAK---------------EYLPEKIREGKLLP---------------------------------------------------- [301] gi|34395897|sp|Q8TQF8|TOP6A_METAC_Type_II_DNA_topoisomerase_VI_subunit_A ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGDVNNEVNSKK-RQGD---------------------TLAKERLLGLAEKIYNQFEE-------------------------------EVIPSV-------SLPSRT-KANIEYSDESDVW------------VYGDRES-ERSAK---TVKGAFQL---------------------LKTTYATDFLINEHLAHNRGSTL-------------RELYYISEGWD-------------YAKF------KEQAESDRLIEDLELLTSLQREY-FHMRP----EEDGATMFGP-IEISELTKRGA--RNI------HCQKDVGEGGYQIPFNV--EN--IEF----------------------K---NHDASMIIAIETGGMYARLMENGFDEA--Y-N-AILVH-----------------LKG-------------------QPA-----RSTRRIIKRMNEEL--EIPVAVFTDGDPWSY-RIYASV-AYGAIKSAHLS-----EFMATP---AARFLGLQPSDIVEYELS---------------------------------------------------------------------TDKLT----------EQDISALRSELSD--------PRF-ES--EYWKEQIQLQ------------LDIGKKAEQQAFAG-----------------------------------------------------------------------------------KGLD--FVTE---------------VYLPNRLKELGMV----------------------------------------------------- [373] 'gi|55377344|ref|YP 135194.1| DNA topoisomerase VI subunit A [Haloarcula marismortui ATCC 43049] >gi|55230069|gb|AAV45488.1| typ' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSTDSDT-TPDT---------------------EEAREQLIDLAADFYDQFAD-------------------------------GEVPTM-------TIPTRT-KSNIVFDEDEQVW------------VYGDRNS-TRSAK---TISGAEKI---------------------LKAVYTIDFL-SQQLEEDRSSTL-------------RELYYLSESWDLD-----------EAQF------NTQDESNNLIEDLEIVSDVKRED-FHMRP----EESGAKVMGP-LLLREQTNRGD--REI------HCQDDVGQGGYQIPNNP--DT--IEF----------------------L---DNDAKFVLCVETGGMRDRLVENGFDDE--Y-D-ALVVH-----------------LGG-------------------QPA-----RATRRLIKRLHDEL--DLPVTVFTDGDPWSY-RIFGSV-SYGSIKSAHLS-----EYLATP---EAQFIGIRPEDIVEYELP---------------------------------------------------------------------TDPLS----------DSDVNALESELED--------PRF-QT--DFWEEQIELQ------------LDINKKAEQQALAS-----------------------------------------------------------------------------------RGLD--FVTE---------------TYLPERLDEMGIL----------------------------------------------------- [368] 'gi|19915459|gb|AAM04999.1| DNA topoisomerase subunit A [Methanosarcina acetivorans C2A] >gi|20090444|ref|NP 616519.1| DNA topoi' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWKGLKKSWLPG----QRLSGVFEMAGDVNNEVNSKK-RQGD---------------------TLAKERLLGLAEKIYNQFEE-------------------------------EVIPSV-------SLPSRT-KANIEYSDESDVW------------VYGDRES-ERSAK---TVKGAFQL---------------------LKTTYATDFLINEHLAHNRGSTL-------------RELYYISEGWD-------------YAKF------KEQAESDRLIEDLELLTSLQREY-FHMRP----EEDGATMFGP-IEISELTKRGA--RNI------HCQKDVGEGGYQIPFNV--EN--IEF----------------------K---NHDASMIIAIETGGMYARLMENGFDEA--Y-N-AILVH-----------------LKG-------------------QPA-----RSTRRIIKRMNEEL--EIPVAVFTDGDPWSY-RIYASV-AYGAIKSAHLS-----EFMATP---AARFLGLQPSDIVEYELS---------------------------------------------------------------------TDKLT----------EQDISALRSELSD--------PRF-ES--EYWKEQIQLQ------------LDIGKKAEQQAFAG-----------------------------------------------------------------------------------KGLD--FVTE---------------VYLPNRLKELGMV----------------------------------------------------- [393] 'gi|6716731|gb|AAF26720.1| Spo11 [Coprinus cinereus]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLSFLKQIEACGAVILDDGEE---------------------------SQGKKQRPKL-------EIQLAD-RKRLTVDGEPAKR--------------------SLKFPKRFATGSSRSM---------------------AQLFRVLDIM-HEGLVTGTPTTK-------------RDIYYKD-----------------VALF------GRQSVVDTLVDDLAATWGTQRCD-LNVRA----ASKG-LVCGAGITINLYSG-----EVV------QGND---TEPSNIPAGEDIES--FGV--------------------------DEDIAWVLVVEKEAVFQTLCQLGVTHGLNIGK-GIMVT-----------------GKG-------------------YPD-----IATRHLVKSLGDALPKHVALAALVDCDPYGI-DILSVY-RYGSQSMRHEN-----DTLATR---RIKWLGLRISEVMEWDLD------------------------------------------------------------------PSLLLPLT----------DYDENKIRSMLKR--------PHL----PRRWRDELEAT------------QARGRKAEIEVLCS-----------------------------------------------------------------------------------LPRD-----QALRIGVGDSMNNPLLAYVEQKLHSLISRAS--------------------------------------------------- [369] 'gi|72397433|gb|AAZ71706.1| type II DNA topoisomerase VI, subunit A [Methanosarcina barkeri str. fusaro] >gi|73670271|ref|YP 306' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARKISNKK-TQRD---------------------LLAREKLFELAEKIYNQFEN-------------------------------EVVPSI-------SLPSRT-KSNLEYSNESDVW------------VYGGRES-ERSAK---TVKGAFQL---------------------LKTTYATEFLINEHLAQSRGSTL-------------RELYYISEGWE-------------AAKF------KEQAESDRLIEDLELLTNLQREY-FHMRP----EEDGATMFGP-IEITEQTNRGE--RNI------HCQKDVGEGGYQIPFNV--EN--IEF----------------------K---AHDASMIIAIETGGMYARLMENGFDEA--Y-N-AILVH-----------------LKG-------------------QPA-----RSTRRIIKRMNEEL--GIPVAVFTDGDPWSY-RIYASV-AYGAIKSAHLS-----EFMATP---AAKFLGLQPSDIVEYELS---------------------------------------------------------------------TDKLT----------EQDINALRSELSD--------PRF-ES--DYWKEQIQLQ------------LDIGKKAEQQAFAG-----------------------------------------------------------------------------------KGLN--FVTE---------------VYLPNRLKEMGML----------------------------------------------------- [369] 'gi|88951300|ref|ZP 01153814.1| DNA topoisomerase, type II [Methanosaeta thermophila PT] >gi|88929422|gb|EAR48371.1| DNA topoiso' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------SDPESRLLSIARSLYDQFRE-------------------------------GTVPHL-------VLPTRT-KKNIEYSTKDDVW------------VYGDQES-VRSVK---TIRGAKTL---------------------LKTVHLVDLLVKEHLRGNRASTL-------------REIYYISENWD-------------LAKF------AEQAESDRLIEDLEIITGLQREE-FHVRP----EEDGAAVFGP-LRIRERTRRGE--REI------HCQEDIGEAGYQIPFNV--DF--VEF----------------------L---EHDARMVIAVETGGMYARLIENGFDEE--F-D-AILVH-----------------LKG-------------------QPA-----RSTRRFIKRLNTEL--GLPVAVFTDGDPWSY-RIFASV-AYGAIKSAHLS-----EHLATP---DARFLGVQPTDIVEYNLS---------------------------------------------------------------------TDKLT----------DRDLHALRAELTD--------PRF-GS--DYWQMQIQLQ------------IDLKKKAEQQAFAG-----------------------------------------------------------------------------------KGLD--FVTK---------------RYLPERLSELGMV----------------------------------------------------- [357] 'gi|76802378|ref|YP 327386.1| DNA topoisomerase VI subunit A [Natronomonas pharaonis DSM 2160] >gi|76558243|emb|CAI49831.1| DNA' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSESDT-DTED---------------------EIARERLIELASDFYDQFAE-------------------------------GEVPTM-------EIPTRT-KSNIVFDEDKDVW------------VYGDRTS-TRSAN---SVRGAQKL---------------------LKAIYTIEFL-ADQLEQGRSSTL-------------RELYYLSESWDEE-----------RAQF------NDQDESNQLVEDLEIVSKVTRED-FHMRP----EESGATIMGP-LYLREQTRRGE--REI------HCQKDVGEGGYQIPNNP--DT--IEF----------------------L---DNDADFVLCVETGGMRDRLVENGFDEE--H-N-VIIVH-----------------LKG-------------------QPA-----RATRRITKRLHDDL--DLPVVVFCDGDPWSY-RIYASV-AYGSIKSAHLS-----EYLATP---EAEYIGIQPADIVEYDLP---------------------------------------------------------------------TDPLS----------DSDINALESELDD--------PRF-QD--DYWREQIELQ------------LDIGKKAEQQALAS-----------------------------------------------------------------------------------RGLD--FVTE---------------TYLPERLGEMGVL----------------------------------------------------- [368] 'gi|68210402|ref|ZP 00562267.1| DNA topoisomerase, type II [Methanococcoides burtonii DSM 6242] >gi|68185894|gb|EAN00612.1| DNA' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVDTINSNYTEQK-KQND---------------------HLAKNRLMGLAEGLYDQFID-------------------------------ETVPNV-------SISSRT-KNNIEYSNESDVW------------VYGDKET-QRTAK---TVKGAFQL---------------------LKTVHSIDFLVKNHLAQDRGSTL-------------RELYYISENWD-------------IAKF------REQAESNRLIEDLEIITSLQREY-FHMRP----EEDGATMFGP-IRIREETKRGS--RII------HCQEDIGESGYQIPFNV--EN--IEF----------------------L---DHDAKFIIAIETGGMYARLIENGFDEK--Y-N-AILVH-----------------LKG-------------------QPA-----RSTRRLIKRMNEEL--GIPVVVFTDGDPWSY-RIFASV-AYGAIKSAHLS-----EFMATP---AAKFIGVQPTDIVEYELS---------------------------------------------------------------------TDKLT----------DKDVDALRSELTD--------PRF-AN--DYWKEQISLQ------------LSIKKKAEQQAFAG-----------------------------------------------------------------------------------KGLD--FVTD---------------TYLPNRLSEMDII----------------------------------------------------- [373] 'gi|6224926|gb|AAF06017.1| meiotic recombination protein Rec12 [Schizosaccharomyces pombe] >gi|2370483|emb|CAB11511.1| rec12 [Sc' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNS-NDKK---------------------KVVRSWIEQFVHDFVEQLSK-------------------------------PTKDSV-------NVALKR-RKHNSWNGSLDS-------------KANERQK-VKVFS---FPRNETTI---------------------AQLFRVLDCV-HEAVISDTVITK-------------RDIYYRD-----------------VDLF------KRQTVVDELLGDISNTIGCSRSD-LNVEA----SAKG-LVFGS-IHIALENG-----TVI------TATK-----PLLISHHR------ISS----------------------I---TSTAKWVLVIEKEAVFQTLTEEALAD-------TIIVT-----------------AKG-------------------FPD-----LMTRKFLVKLAKALP-DAKFFGIFDWDPHGL-CIYSCF-KYGSNAYSHEP-----HS-QLR---NLQLLGPLYEDIFNKNQ--------------------------------------------------------------------EFSLKLN----------KRDIKMITTLLQF--------EGF-QKE-PVVREQLQRM------------LFIQKKAEIQAILE-----------------------------------------------------------------------------------FP-----------------------SWIKGKLADAD-----------------------------------------------KSGKHSVR [345] lcl|Ppa_RHL2_402_1_unnamed_protein_product ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?VFITCNI------------------------------------------VIHIN-QSFSE--------------------------------------------------------------------------------------------------------------------------------------TFT--AS--LLD----------------------L---SSSAEYILLVEKETVFQRLANDKFCAK--N-C-CILLT-----------------GKG-------------------YPD-----VATRSFLRRLVDQL--HLPVYGLMDGDPYGL-DILSIY-RFGSLTMAYDA-----KVLAVP---SILWLGIFLSDLGHFGLT------------------------------------------------------------------ENCLLPMS----------KRDHYIPSKIRGQ--------CYI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- [161] 'gi|88604153|ref|YP 504331.1| DNA topoisomerase, type IIB [Methanospirillum hungatei JF-1] >gi|88189615|gb|ABD42612.1| DNA topoi' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTR-------------------------------GELPSI-------TMPTRT-KRNIAYDEEAEVW------------KYGDRER-LREAG---TEKSALHI---------------------LKMAYVIWFL-KHQITENRSSTL-------------RELYYISEGWK-------------RAKF------AAQNDSNLLVEDLEILTDVQREH-FHLRP----EEDGASIFGP-LRIREDTRRGT--REL------HCQDDIGESGYQIPTNV--DS--LEF----------------------V---EHDAQMVIAIETGGMYARLIENGFDEK--Y-Q-AILVH-----------------LKG-------------------QPA-----RSTRRVLNRLASEF--QLPVTVFTDGDPWSY-RIFASV-AYGAIKSAHIS-----EILVTP---SARFIGVQPSDIRDYDLP---------------------------------------------------------------------SDLLT----------EQDIAALKAELTD--------PRF-AG--DYWKEQINLQ------------LALNLKSEQQAFAA-----------------------------------------------------------------------------------RGLD--FVTD---------------EYLPARLSDMGVLRK--------------------------------------------------- [340] 'gi|71483085|gb|AAZ32518.1| DNA topoisomerase VI subunit A [uncultured euryarchaeote Alv-FOS4]' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGS---------------------EEALKKLYEIAEEIYAQLER-------------------------------GDIPHM-------KLAARH-KGNIVFDPRTGVW------------KYGDSRI-TRSAK---KLDGGYMI---------------------LRTLYIMEFI-KDMIRTKKSSTL-------------REMYYISEGWD-------------MAKF------HSQDESNKLAEDLEVITGFMRED-FKLRP----EEDGASVIGN-ITVEEINRKGKP-MRI------NCRDDVGDSGYLIPYNVENDK--LKF----------------------V---DVDADFVIGIETGGMFDRLVENGFDEK--A-R-AVLVH-----------------IKG-------------------QPA-----RSTRRLLKRMNEEL--GLPVVIFTDGDPWSF-RIFASI-AYGAIKTAHIS-----EYLATP---TAEFVGITASDILNYDLP---------------------------------------------------------------------TDKLN----------DRDIAALKAELKD--------PRF-NT--PFWNEEIRLM------------LDIKKKAEQQALAK-----------------------------------------------------------------------------------YGLD--YVTD---------------TYLPEKLTELGVMK---------------------------------------------------- [362] 'gi|33304618|gb|AAQ02689.1| meiosis-specific topoisomerase Spo11 [Sordaria macrospora]' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYFCPIRNQFLQPRSQPPSQPPSQPPSQLPSQPNSQPGTRTGHGQPNPPLM----QGNSVGVGRGRVSRNIVTIPQ-SHFN---------------------DDALAKIETLFETILDAVSV-------------------------------GGPV---------VIPYRRSTNAQTFNATAFTS------------NPSDGRHIDSVRFPGRNPQELRRF---------------------EALFRIIELS-HEALLSGTLITK-------------RNIYYQN-----------------MELF------RSQSMVDEMVDNLAFTLGVGRGD-LNIVA----TAKG-LIAGQ-VQLMMRGG-----TSI------NCAE-SSDSGVLLPSISAVEK--IDF---------------------------QSVKWLLVIEKEATFRTLSASRYHAVSRAGS-GILVT-----------------GKG-------------------YPD-----LATRKFLATLHFVQP-RLPMFALVDFDTHGI-SILRTY-QYGSQRLDHE------ERTKVP---RLRWLGIRSSDVLSQTMVTQDPSANNQDSQSSQDLSSQESIAYSVD------------------ALQDERPTKRPRTRRTKSHPSDSTAPLN----------EGDREKAVSVLRDICTT----ARL-DSSGREHKLELQRM------------LLLNVKAEIQAVDD-----------------------------------------------------------------------------------FGDI--------------------TNWLDERLLSQSR------------------------------------------------------ [481] 'gi|3879464|emb|CAA92974.1| Hypothetical protein T05E11.4 [Caenorhabditis elegans] >gi|17542064|ref|NP 502081.1| homolog of yeas' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYEYSFNPNIDHEPGSVESQQSTIYSDSDDSDDSFLDDE--------------------------------------------------------------------V-IPPK---------------------EQAMRKIEFALADIKRQMDN-------------------------------KEKSL----------------------------------------TLRISTS-KSHFCLRYTAKRKGKL---------------------DRDLHCLHQV-YDLLENDKRSTK-------------RELYYEH-----------------KAVY------GNQKYLDSSIKSICELLNESRAN-LNILS----CGRG-IIRGA-ITFLVENV-----GVI------DARV-----QEVLITDA--LL--FSN----------------------I---ISEADFILVVEKDTTFQKLMDENFQAM--FPR-GILAT-----------------SKG-------------------YPD-----IATRNVLKMLSEKR--KFPIYGLFDADPHGI-EIYLTY-KYGPTKEFAEG-----RGAFVP---TIEWIGLFPTDFHRFTID------------------------------------------------------------------QSQCLPLV----------RTDFVKIEKMIPR--------SIQ-LGE-IVVTRELDWM------------IQNKFKMELESINM-----------------------------------------------------------------------------------CGQE--YMAR---------------FLIAPRVMSIEKEI--PIQPETIINEYHEDSQCSLSTDDDREAKDDDYIDSDAEEKFQNMIDNDSD [425] 'gi|57228579|gb|AAW45014.1| endodeoxyribonuclease, putative [Cryptococcus neoformans var. neoformans JEC21] >gi|58270330|ref|XP' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPLPSPSYSGSPAHHMDKEDKDILLVEGKNSCHRIDLSGSSEDSGRDTIQVDDDSGDEDDLVWALIADDLNSDASTHDIEDRNEEAQEALFEQLIRRTEAMRNPATQTASLQTQFEVSDDDE----NDFVIDEPYSESLIEDGIQVS-DEGR---------------------ENALKFLQSIVLSFLEQISTSLGTIFSHETSKVHKKELKGLKRRKIYAAEAEQKKETDQCLETGKIGVTISLKNRKSGSYQAI-------------MLPDSPLQSPD-----RQSSIMRM---------------------TCIMRVASTL-YEAILDRNVITL-------------RDVYYRD-----------------KQLF------ERQPVVDKIVDDLVATAGLRRRD-FYVCA----SAKG-LIASSSLVIRYRTG-----DEI------ILSA---TRANLVDPAEKIDV--IEA--------------------------PNGLDWVLIVEKDAIFQSLCGAGILQDERIGH-GVLIT-----------------GKG-------------------FPD-----LATRQILRLIADTFP-CVKMYALVDADPHGL-KILSTY-MYGSKANAYST-----DYGDLPLGDRVQWLGLRASHWSDLHIS------------------------------------------------------------------YDHLIPLE----------QSDIQMAMSMLRD-----------HQTLPVEWKRELSHM------------LHLHRKAEIEIIIA-----------------------------------------------------------------------------------SSWSSDHVGS----------------------------------------------------NGSGDREGDRQPLPDVERLINYIVKNMGF [559] 'gi|67476294|ref|XP 653750.1| topoisomerase [Entamoeba histolytica HM-1:IMSS] >gi|56470731|gb|EAL48364.1| topoisomerase, putativ' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTNS---------------------NDVICIIEEIIQFVVKGLAQ-------------------------------RHQFPLLQTQRNCNVRCPR------------------------------------------LTVKKKKY---------------------FKFLVILSTI-HELILSNKQFTV-------------RELYYTH-----------------KTIF------KDQTELENLIGDVKLLFGVNDLNVLHLTH----TPRG-ILYGE-VTLVTPI------YVM------DFTK-----KLQLPILS--SP--FQF---------------------II---PSQRCFLLIVEKEAFFERLIQSHLIDQ--F-P-CIILC-----------------SRG-------------------FPD-----NSTFTIAHHLTQKP--NIIPCCLVDGDVYGI-EIFLTF-LCGGWKKNRLSGTSKPSDDGIS---LLRWSLLRPSDYKG-------------------------------------------------------------------------VSPLT----------NREKIIASHMLES--------EVV-KYN-QEIELEIKTL------------LKNNTKMELDELAN-----------------------------------------------------------------------------------TNVS--FFET---------------TIISSCLSHST--------------------------------------------LFKIPTDVKKN [340] 'gi|39593715|emb|CAE62007.1| Hypothetical protein CBG06015 [Caenorhabditis briggsae]' -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFEHNDRGDDFRKNESVVSTQCTSYESSDESDDSFIDEE--------------------------------------------------------------------V-IPLK---------------------IQAIRKIEFALADIQEQIER-------------------------------DDKTL----------------------------------------ILRTSHD-KSKFSLRYSPRMKKKL---------------------DRDLHCLHQI-YDLLENDKKSTK-------------RELFYEH-----------------KLIY------EVQRNLDSSITSIYALI------------------------------------------------------------------------YAD----------------------I---VSEAEFVLVVEKDTIFQKLKDEDFQKM--FPR-GILVT-----------------SKG-------------------YPD-----IATRNVLKMFGERK--NFPIYGLFDADPHGI-EIYLTY-KYGATKETAEG-----RGAFVP---SIQWIGLFPTDFKNFFID------------------------------------------------------------------KSQQLPLI----------RSDYVKIENLIPR--------SIQ-LGE-ISVTRELDYM------------IQNPLKFELESINM-----------------------------------------------------------------------------------CGPE--YMGR---------------YLIAPRVKKVEKKIMDPIE-EVEAEQGSLDSQLSFDANTSDEDLDDCYADSDTERMMDDLIDNDSD [381] 'gi|39576479|emb|CAE80644.1| top6A [Bdellovibrio bacteriovorus HD100] >gi|42524271|ref|NP 969651.1| DNA topoisomerase VI subunit' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKLLSI-RDLK---------------------IDIPKEARILADKMLKDLES-------------------------------SKRPVL-------EAVKTS-LDNSLYNAKVGYL------------TPGDKV--VRTEL---NVSSVQKL---------------------ARVVFLLEML-LRNLETGTVNTK-------------RELYYMCKGEIKGNP------RLKPLDF------DDQPESDAIIDFIGDMLEVYREE-LNVFA----NDRGGQTYSQQLVV-TETLTDGDKAVI------DLST-LGTSPFQPKNKP--QALKLKA--------------------------KKKIDFCLIVESEGTANTLVTMGFTKR--N-N-CIVMG-----------------AQG-------------------VPS-----NGVRGWAKLIQEEL--DVPMYFFGDLDAYTMQNIFRTL-KAGSAASLIRN-----ADFSAP---NVKFLGVLPEDVKKYDLP---------------------------------------------------------------HYKVKESDPAE----------ARALKKAKDALEN---D----PFFLDKKNKNLADILRWL------------IKEKIRCEQQSFFS-----------------------------------------------------------------------------------VDPKDPIKTE---------------KLILEKIKRGSYV----------------------------------------------------- [387] 'gi|71403068|ref|XP 804374.1| meiotic recombination protein SPO11 [Trypanosoma cruzi strain CL Brener] >gi|70867310|gb|EAN82523.' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAAVSSPSSSNTSAAAVVAKRLTRQKKQR----PVLASSEDEFIGPDIVAVNTP-AAIT---------------------DEAVRRMEVFVLQTIHEIVT----------------------------------------------------------------------------------TTQRSTI---RESRLRVI---------------------RLQLLVLRLL-YQNIHCGIISTQ-------------RDVYYRL-----------------ARLV------PDQGCINRVIQQLVQIIGIPRQW-LGVVP----GTRG-CVGGS-ISF----------HGV------DLRC-YGSEGLPLPTTQ--EE--LRVVQGDVDRTAASNKDNVPFIGFEI---HGKTRYIVVVEKHAVFFRLMEERIFER--L-P-CVLLT-----------------SHG-------------------FPT-----VAARTLLSNLHRAAQ-SAPLVALVDYNPSGL-SILQQY-KYGAGGMR-ES-----QYAAVH---ALHWLGLRTHHIAEGREP----------------------------------------------NFLDSDNSVASEPFQLRLLPRLPFQRFS----------QRDVVMMANLLSRWHGIREGCEWKDNDADNAWYEEALKM------------QHLRVKVELEVLYQ-----------------------------------------------------------------------------------HGTD--ELKQSASSSLEPSDGNGFAAWVCRAILRHDYI----------------------------------------------------- [437] 'gi|71416166|ref|XP 810124.1| meiotic recombination protein SPO11 [Trypanosoma cruzi strain CL Brener] >gi|70874610|gb|EAN88273.' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAAVSSPSSSNTSAAAVVAKRLTRQKKQR----PVLASSEDEFIGPDIVAVNTP-AAIT---------------------AEAVRRMEIFVLQTIHEIVT----------------------------------------------------------------------------------TTRRSTI---RESRLRVI---------------------RLQLLVLRLL-YQNIHCGIISTQ-------------RDVYYRL-----------------ARLI------PDQGCINRAIQQLVQTIGIPRQW-LGVVP----GTRG-CVGGS-ISF----------HGV------DLRC-YGSEGLPLPTTQ--EE--LRVVQGDVDRTAASNKDNVPFIGFEI---HGKTRYIVVVEKHAVFFRLMEERIFER--L-P-CVLLT-----------------SHG-------------------FPT-----VAARTLLSNLHRAAQ-SVPLVALVDYNPSGL-SILQQY-KYGAGGMR-ES-----QYVAVH---ALHWLGLRTHHIAEGREP----------------------------------------------NFVGSDNRVASEPFPLRLLPRLPFQRFS----------QRDVVMMANLLSRWHGIREGCEWKDNDADKAWYEEALKM------------QHLRVKVELEVLYQ-----------------------------------------------------------------------------------HGTD--ELKQPASSSLELSDGNGFAAWVCRAILRHDYI----------------------------------------------------- [437] 'gi|89301261|gb|EAR99249.1| Type IIB DNA topoisomerase family protein [Tetrahymena thermophila SB210]' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNFNQLKSLN----AQILQRHFEALNFLGIQYSIH-DLDK---------------------ESIINRLRDFFFQLLKEIIIQNSCLKLMEKKDIQFDYFYFIHAEQQYISNQ-------------SLEITSQKYQNFYSQFQSLR------------KLNKEGKNKTMVI---HKNNLKSL---------------------EKLLFCIKQI-LNALKNDFQITK-------------REIFYTN-----------------VELFD-----QNQQNLEKIIQILQNQLRLPRNC-LNIIA----SAKG-LVTGN-VQFQVSSQ-----AEVKFLYFIDLSKNFGEVRQIQPKEE------ILW----------------------I---ETNSAFILVVEKETVFQKIIAEKDEQL--LKN-CIMIT-----------------GKG-------------------YGD-----YSTKQYIKMLTANNP-NSPLFYLGDFDPFGL-DILFNY-TFGSENSVYQQ-----DNL--P---NIHFLGLSSFDILDFNQQ-------------------------------------------------------------SDEKKFNVENNLS----------KQDICKLDALIAK----------FEFSKLNQLKNNYLQIPKDKIDSNKLDDLTSQRKVEMDKLFGRVIRRNQAAEEFMKNEDAKAHEKETVKQNMQIQTGIKVALRLSFIGSVALLYKRGFFAKQSPFFMRELLLMVGGYGVISIGDFFASE--YMWSNAGTIIRRYTNYSDSYYVDDKTYNKM-----------------------------KEMYKLKQNQPQQTVEYQENNDKMYD [557] 'gi|46123143|ref|XP 386125.1| hypothetical protein FG05949.1 [Gibberella zeae PH-1] >gi|42552751|gb|EAA75594.1| hypothetical pro' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQDPYIAQAIAIPELTQR----HQTNLPSSATITNNDTNTIIH-NTNV---------------------GAAVARIEGILEQIIDALAA-------------------------------GQELSI-------AFSTRK-PSRQASNATP-----------------------EQVHFPGRNKQEATKF---------------------ARILLILQLS-HDALVSGTVLTK-------------RHIFYQH-----------------QDLF------EKQREVDDLVDDIAFTLGISRGD-LNIVA----ASKG-VLAGP-LTIGLHDG-----STL----------------------------------------------------------NPCLGDLILIGVGSSYPNCSVNFWCRH----PRCQIDS-----------------GSGEGCRLQITLLLSILEGVSVWPRCTCHYLTTRSFLNLVSTRYP-QLPILGLFDFDPDGV-KIMRCY-RYGSDRLSHEA------DLGTE---TLQWLGIKSTHLFRDYAG----------------------------------------------DSATITPSQSSPSSITSTSCRNPVSYMS----------ARERTAAISTLKKVVHP----SHL-GTEVSETKHELQLM------------LVLGVKAEIEWLDE-----------------------------------------------------------------------------------SGDL--F------------------SWLDDEIGEAL--------------------------------------------------ISDMI [414] 'gi|82596810|ref|XP 726415.1| topoisomerase VIA [Plasmodium yoelii yoelii str. 17XNL] >gi|23481817|gb|EAA17980.1| putative topoi' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLNYL-----------------------------YFL---------------------------------------------------------------------------------------------------LTEYGLMINDNL--LN--VDK----------------------V---ESLAHYILVVEKYSLYQKLCEKKIWNI--L-P-LILIT-----------------GKG-------------------FPD-----YATRKIIYELISLF--HFECVYVGDYDPYGI-RIYLSY-KEGCKNNQN-------FVYACK---DMKWVGMCFNDINFFPK--------------------------------------------------------------------ESLLSLS----------MKEKHVIENLLND--------KKL-YYS-SKLRTEISEM------------NEKNIKFEIEAFEY-----------------------------------------------------------------------------------VGME--FFVK---------------NYLIKKILRKQWLE---------------------------------------------------- [205] ; END; BEGIN CODONS; CODESET * UNTITLED = Universal: all ; END; BEGIN ASSUMPTIONS; OPTIONS DEFTYPE=unord PolyTcount=MINSTEPS ; EXSET * UNTITLED = 1-1025 1049-1056 1061-1077 1081-1099 1103-1107 1122-1123 1139-1142 1146 1153-1171 1186-1274 1287-1512; END; BEGIN MacClade; Version 4.0 87; LastModified -1037648840; FileSettings editor '0' '0' '1' '1'; Singles 100; Editor 00011001111111100100010010 '1' '8' Geneva '10' '624' '1' all; EditorPosition '72' '-6' '1027' '1295'; TreeWindowPosition '46' '6' '1131' '1550'; ListWindow Characters closed Geneva '9' '50' '25' '273' '366' 000; ListWindow Taxa closed Geneva '9' '50' '10' '276' '490' 100000000; ListWindow Trees closed Geneva '9' '50' '10' '276' '490' ; ListWindow TypeSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow WtSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow ExSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow CharSets closed Geneva '9' '50' '10' '276' '490' ; ListWindow TaxSets closed Geneva '9' '50' 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